Case of mania induced by withdrawal of interferon‐α in a patient affected by bipolar disorder

Rossi, Alessandro; Renzetti, Daniela; D'Albenzio, L.; Gianfelice, Daniela; Kalyvoka, Artemis; Rinaldi, Osvaldo

doi:10.1046/j.1440-1819.2002.01070.x

Cited by 9 publications

(5 citation statements)

References 5 publications

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“…However, cases have been reported of interferon-induced depression followed by mania (43,44). Since mania usually occurred after discontinuation of interferon in these cases, these observations are ambiguous-they may represent the evolution of an interferon-induced bipolar disorder or the behavioral expression of putative neuropharmacological effects of interferon discontinuation.…”

Section: Discussionmentioning

confidence: 99%

Mania During Treatment of Chronic Hepatitis C With Pegylated Interferon and Ribavirin

Onyike¹,

Bonner²,

Treisman³

2004

AJP

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Section: Discussionmentioning

confidence: 99%

Mania During Treatment of Chronic Hepatitis C With Pegylated Interferon and Ribavirin

Onyike¹,

Bonner²,

Treisman³

2004

AJP

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“…Progressive depressive symptoms during the fifth week of treatment with IFN alfa necessitated discontinuation of therapy. Another case report has shown occurrence of manic symptoms in a patient with bipolar disorder after discontinuation of IFN alfa (43).…”

Section: Mood-related Symptomsmentioning

confidence: 99%

Neuropsychiatric Complications of Interferons: Classification, Neurochemical Bases, and Management

Malek-Ahmadi¹,

Hilsabeck²

2007

Annals of Clinical Psychiatry

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“…It may represent a withdrawal syndrome or an extreme presentation of IFN-induced affective instability [26][27][28][29].…”

Section: Mood Disordersmentioning

confidence: 99%

“…The usual approach would include discontinuation of IFN therapy, although some reports suggest this would precipitate or exacerbate such presentations [27,28]. Antipsychotic and anxiolytic medications are appropriate for rapid stabilization, depending on individual symptoms.…”

Section: Management Of Neuropsychiatric Side Effectsmentioning

confidence: 99%

Neurobehavioral effects of interferon therapy

Valentine¹,

Meyers

2005

Curr Psychiatry Rep

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Interferon (IFN) therapy is associated with neuropsychiatric side effects including cognitive dysfunction and mood syndromes of varying severity. These problems are the most common causes of treatment discontinuation. Dose and duration of treatment influence risk of IFN-induced side effects. Rates of IFN-induced depression vary, but approach 50% in recent studies. Presence and severity of depressive symptoms at or before treatment predicts development of mood disorders during IFN therapy. Several possible endocrine and neurotransmitter perturbations may be responsible for IFN neurotoxicity, with recent research suggesting different symptoms clusters are related to different underlying mechanisms. The interpretation of these clusters has been influenced by subjective versus objective evaluation of cognitive function. Effective management of IFN-induced neuropsychiatric side effects should involve pretreatment screening and interval assessment during therapy. Antipsychotic and psychostimulant drugs may be used against cognitive dysfunction. Antidepressants have been shown to be effective against IFN-induced depression and can be very valuable in support of adequate or completed therapy.

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Case of mania induced by withdrawal of interferon‐α in a patient affected by bipolar disorder

Cited by 9 publications

References 5 publications

Mania During Treatment of Chronic Hepatitis C With Pegylated Interferon and Ribavirin

Mania During Treatment of Chronic Hepatitis C With Pegylated Interferon and Ribavirin

Neuropsychiatric Complications of Interferons: Classification, Neurochemical Bases, and Management

Neurobehavioral effects of interferon therapy

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