Case of lichen planus induced by sitagliptin phosphate hydrate

Dipeptidyl peptidase‐4 inhibitor‐associated cutaneous eruptions: a retrospective observational study

“…In addition to BP, various other DPP-4 inhibitor-associated dermatoses have been described in the literature, including psoriasiform dermatitis, maculopapular rash, photodermatitis, eczematous rash, lichen planus, and even alopecia areata and mucositis. [5][6][7][8][9][10][11] Since the first case report in 2011 of DPP-4 inhibitorassociated BP, various publications have implicated DPP-4 inhibitors in the pathogenesis of BP. 12 DPP-4 inhibitors have been associated with a 3.2-fold increase in risk of developing BP, with vildagliptin and linagliptin being the most common inducing agents.…”

“…The literature on other DPP-4 inhibitor-associated cutaneous AEs remain limited to various case reports. [5][6][7][8][9][10][11] Lichen planus pemphigoides has been reported as an AE in a patient on vildagliptin, 18 while sitagliptin has been reported to cause lichen planus and psoriasiform dermatitis. 5,9 In our study, lichenoid dermatitis represented a significant portion (22.2%) of the cutaneous AEs noted, and this finding warrants further investigation.…”

“…[5][6][7][8][9][10][11] Lichen planus pemphigoides has been reported as an AE in a patient on vildagliptin, 18 while sitagliptin has been reported to cause lichen planus and psoriasiform dermatitis. 5,9 In our study, lichenoid dermatitis represented a significant portion (22.2%) of the cutaneous AEs noted, and this finding warrants further investigation. Of the four patients with lichenoid dermatitis, one had bullous lichen planus.…”

“…Most of the existing literature focuses on DPP‐4 inhibitor‐associated BP, and thus ours is perhaps the first observational study characterizing other cutaneous AEs as well. In addition to BP, various other DPP‐4 inhibitor‐associated dermatoses have been described in the literature, including psoriasiform dermatitis, maculopapular rash, photodermatitis, eczematous rash, lichen planus, and even alopecia areata and mucositis 5–11 …”

“…The literature on other DPP‐4 inhibitor‐associated cutaneous AEs remain limited to various case reports 5–11 . Lichen planus pemphigoides has been reported as an AE in a patient on vildagliptin, 18 while sitagliptin has been reported to cause lichen planus and psoriasiform dermatitis 5,9 .…”