Case of Immune Aplastic Haemolytic Anaemia with Thrombocytopenia

Lees, Michelle; Fisher, O. D.; Shanks, John

doi:10.1136/bmj.1.5166.110

Cited by 7 publications

(1 citation statement)

References 2 publications

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“…Interestingly, the reticulocytopenia observed in affected patients may be associated with hyperplasia [3][4][5][6][7] or hypoplasia of bone marrow [8][9][10][11][12]. These findings might be explained by the presence of autoantibodies reacting with red blood cells (RBCs), reticulocytes and/or erythroid progenitor cells [8,[13][14][15].…”

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confidence: 99%

Erythropoietin May Improve Anemia in Patients with Autoimmune Hemolytic Anemia Associated with Reticulocytopenia

Arbach

Funck

Seibt³

et al. 2012

Transfus Med Hemother

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Background: Management of patients with autoimmune hemolytic anemia (AIHA) and reticulocytopenia remains challenging. Case Reports: Two patients with decompensated AIHA who were receiving immunosuppressive drugs were treated with erythropoietin (EPO). Administration of EPO increased reticulocyte counts and hemoglobin concentrations in both cases. One patient completely recovered following a short course of treatment. Hemolysis could be compensated in the second patient using only mild doses of immunosuppressive drugs in combination with EPO. Conclusion: The administration of EPO should be considered in patients with therapyrefractory AIHA, particularly in the presence of reticulocytopenia.

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Section: Introductionmentioning

confidence: 99%

Erythropoietin May Improve Anemia in Patients with Autoimmune Hemolytic Anemia Associated with Reticulocytopenia

Arbach

Funck

Seibt³

et al. 2012

Transfus Med Hemother

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Reticulocytopenia in severe autoimmune hemolytic anemia (AIHA) of the warm antibody type

Hauke

Fauser

Weber

et al. 1983

Blut

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A patient with severe AIHA of the warm antibody type, absence of reticulocytes and red cell hyperplasia of the bone marrow is described. In order to maintain a reasonable hemoglobin level 38 units of washed packed red cells were required within 24 days. The treatment with high doses of steroids showed no permanent beneficial effect. After splenectomy the red cell destruction was immediately reduced and the patient went into a remission. Bone marrow culture studies during the acute phase of the disease and at the time of complete hemato- and immunological remission, i.e. 4 months after splenectomy suggested a circulating autoantibody directed to early erythroid progenitors (BFU-E). The inhibitory activity in the patient's plasma did not influence granulocytic or mixed colony formation (CFU-GEMM). In addition to autoantibodies directed to erythroblasts and erythropoietin involved in the pathogenic mechanisms leading to red cell aplasia type I and II the culture studies suggest an unusual autoantibody that might cause the observed reticulocytopenia and erythropoietic hyperplasia of the bone marrow in AIHA. After the splenectomy the patient recovered, he required no further blood transfusions and his disease has not recurred.

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Classification and Clinical Characteristics of Autoimmune Hemolytic Anemias

Petz

2004

Immune Hemolytic Anemias

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Case of Immune Aplastic Haemolytic Anaemia with Thrombocytopenia

Cited by 7 publications

References 2 publications

Erythropoietin May Improve Anemia in Patients with Autoimmune Hemolytic Anemia Associated with Reticulocytopenia

Erythropoietin May Improve Anemia in Patients with Autoimmune Hemolytic Anemia Associated with Reticulocytopenia

Reticulocytopenia in severe autoimmune hemolytic anemia (AIHA) of the warm antibody type

Classification and Clinical Characteristics of Autoimmune Hemolytic Anemias

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