Case of benralizumab‐induced exacerbations of chronic spontaneous urticaria

Magen, Eli; Komarova, Irina; Magen, Israel; Phirtskhalava, Sofia

doi:10.1002/ccr3.5930

Cited by 5 publications

(3 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 3 , 4 In 1 notable case, a patient started on benralizumab for eosinophilic asthma experienced a flare of his chronic spontaneous urticaria that was previously in remission. 5 The authors of this report theorized that paradoxical IL-5 expression and an increased eosinophil level may have contributed to this patient’s flare; however, this was felt to be unlikely as these levels were normal. A more likely hypothesized mechanism is that benralizumab’s high affinity for the FcγRIIIa receptor of natural killer cells may have led to increased mast cell activation and subsequent pathology.…”

Section: Discussionmentioning

confidence: 85%

A case of paradoxical eosinophilic fasciitis in a patient on benralizumab

Woodbury¹,

Gaffney²,

Merola³

2023

JAAD Case Reports

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 85%

A case of paradoxical eosinophilic fasciitis in a patient on benralizumab

Woodbury¹,

Gaffney²,

Merola³

2023

JAAD Case Reports

View full text Add to dashboard Cite

“…Moreover, since adenosine suppresses the gap formation of vascular endothelial cells and antigen-IgE-related histamine release from peripheral blood basophils and skin mast cells activation via adenosine receptors (A2a and A2b), adenosine and adenosine analogs (including agonist for A2a and A2b) could also be effective for treating CSU. On the other hand, crucial involvements of IL-4 and IL-5 in the pathogenesis of CSU were suggested via the favorable results of clinical trials of the anti-IL-4/13 receptor antibody, dupilumab [ 61 ], anti-IL-5 (mepolizumab, reslizumab) [ 62 , 63 ] and anti-IL-5R (benralizumab) antibody [ 64 ]. Moreover, levels of IL-4 in plasma and numbers of IL-4 expressing cells in the skin of patients with CSU are higher than those of health controls [ 65 , 66 ].…”

Section: Treatment Targeting Basophil-related Molecules In the Pathog...mentioning

confidence: 99%

Basophil Characteristics as a Marker of the Pathogenesis of Chronic Spontaneous Urticaria in Relation to the Coagulation and Complement Systems

Yanase

Matsubara

Takahagi

et al. 2023

IJMS

View full text Add to dashboard Cite

Chronic spontaneous urticaria (CSU) is a common skin disorder characterized by daily or almost daily recurring skin edema and flare with itch and pruritus anywhere on the body for more than 6 weeks. Although basophil- and mast cell-released inflammatory mediators, such as histamine, play important roles in the pathogenesis of CSU, the detailed underlying mechanism is not clear. Since several auto-antibodies, IgGs which recognize IgE or the high-affinity IgE receptor (FcεRI) and IgEs against other self-antigens, are detected in CSU patients, they are considered to activate both mast cells in the skin and basophils circulating in the blood. In addition, we and other groups demonstrated that the coagulation and complement system also contribute to the development of urticaria. Here, we summarized the behaviors, markers and targets of basophils in relation to the coagulation–complement system, and for the treatment of CSU.

show abstract

“…Dear Editor, In the 10th volume, 6th issue of Clinical Case Reports, we read the article of Dr Megan and colleagues entitled "Case of benralizumab-induced exacerbations of chronic spontaneous urticaria." 1 We thank for their valuable case report which they mentioned about benralizumab induced urticaria. In this case report they gave benralizumab treatment to an uncontrolled severe asthma patient who had an history of autologous serum skin test positive chronic spontaneous urticaria (CSU).…”

mentioning

confidence: 93%