Case of atypical fibroxanthoma in the palpebral conjunctiva

Mochizuki, Kiyofumi; Yamada, Takahiro; Mori, Y.; Sawada, Akira; Mori, Ichiro; Ohnishi, Yoshitaka

doi:10.1007/s10384-008-0565-3

Cited by 14 publications

(11 citation statements)

References 7 publications

(19 reference statements)

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“…1,2 AFX has been reported only rarely in the eyelid 3-5 or conjunctiva. [6][7][8][9] Three of the conjunctival AFX cases involved the bulbar conjunctiva at the limbus 6,7,9 and one was in the palpebral conjunctiva. 8 Previous cases of AFX of the bulbar conjunctiva were in a 5 and 1/2-year-old boy with xeroderma pigmentosum, 5 and men aged 59 8 and 81.…”

Section: Pathologymentioning

confidence: 99%

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Atypical Fibroxanthoma of the Bulbar Conjunctiva

Shieh

Daluvoy

Ellington³

et al. 2015

Cornea

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Section: Pathologymentioning

confidence: 99%

“…1,2 Only rarely has AFX been reported in the eyelid [3][4][5] or conjunctiva. [6][7][8][9] We describe an AFX arising on the bulbar conjunctiva near the corneal limbus.…”

mentioning

confidence: 99%

Atypical Fibroxanthoma of the Bulbar Conjunctiva

Shieh

Daluvoy

Ellington³

et al. 2015

Cornea

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“…Of the five other reported cases, four were found at the limbus, as in our patient [1][2][3][4]. The typical histologic presentation of AFX is spindle, plump, epithelioid and bizarre cells, in various proportions, arranged in haphazard, vaguely fascicular or storiform patterns [4].…”

Section: Discussionmentioning

confidence: 47%

An Uncommon Case of Atypical Fibroxanthoma of the Bulbar Conjunctiva

Suman¹,

Cossack²,

Rupani³

et al. 2017

J Clin Exp Ophthalmol

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An Atypical Fibroxanthoma (AFX) is a benign skin tumor of mesenchymal origin most commonly found on the sun-exposed or radiation-damaged skin of the elderly. AFX may share many common histologic and clinical characteristics with squamous cell carcinoma and melanoma; however, it is a benign process. Therefore, differentiating between these lesions is important. Differences in histologic features and patterns of immunohistochemical staining for CD68, CD10, cytokeratins, S-100 and Fi-67 may diagnose AFX. The presence of an AFX on the conjunctiva is rare with only five other reported cases. We report a case of AFX that developed in the bulbar conjunctiva near the limbus.

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“…The lesion may itself present as a solitary or multifocal red or pink dome-shaped nodule with high vascularity [2,4]. Histologically, it is composed of pleomorphic spindle cells with hyperchromatic nuclei and abundant cytoplasm.…”

Section: Discussionmentioning

confidence: 99%

“…There have only been a few reported cases of ocular surface presentation of this tumor, and only one has been reported in patients without xeroderma pigmentosum. Other reported locations of ocular atypical fibroxanthoma include the palpebral conjunctiva, limbus, and medial canthus [4,7,8]. …”

Section: Discussionmentioning

confidence: 99%

Atypical Fibroxanthoma of the Bulbar Conjunctiva: A Unique Case Describing the Pathology, Clinical Presentation, and Management

et al. 2017

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Background/Aims: Atypical fibroxanthoma is an uncommon tumor that usually occurs in the skin of the head and neck of the elderly with significant sun exposure. We describe a unique case featuring a rare ocular surface conjunctival tumor (atypical fibroxanthoma) and provide insight on its characteristic clinical features, surgical management, and histology. Methods: A 71-year-old male fisherman with no pertinent ocular history presented to an academic center with a rapidly enlarging bulbar conjunctival mass in the right perilimbal region for the past several months. The patient underwent surgical excisional biopsy with cryotherapy, adjuvant alcohol, and amniotic membrane transplantation. Results: Pathology specimen illustrated an atypical spindle cell tumor with inflammatory cells, increased mitotic activity, cytologic atypia, and positive diffuse staining with CD163 and CD10 consistent with an atypical fibroxanthoma. Conclusion: Atypical fibroxanthoma is an extremely rare ocular surface tumor that may simulate conjunctival or ocular surface squamous neoplasia. While this lesion typically pursues a benign clinical course, it may recur or rarely metastasize. Thus it should be treated aggressively with excisional biopsy, cryotherapy, absolute alcohol, and/or amniotic membrane transplantation.

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Case of atypical fibroxanthoma in the palpebral conjunctiva

Abstract: An atypical fibroxanthoma in the palpebral conjunctiva is very rare. The clinical presentation and histological and immunohistochemical studies are helpful in distinguishing between an atypical fibroxanthoma and a malignant fibrous histiocytoma.

Cited by 14 publications

References 7 publications

Atypical Fibroxanthoma of the Bulbar Conjunctiva

Atypical Fibroxanthoma of the Bulbar Conjunctiva

An Uncommon Case of Atypical Fibroxanthoma of the Bulbar Conjunctiva

Atypical Fibroxanthoma of the Bulbar Conjunctiva: A Unique Case Describing the Pathology, Clinical Presentation, and Management

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