Case of acute promyelocytic leukemia with basophilic differentiation and an ETV6 mutation

Ghimire, Anima; Liesveld, Jane L.; Wallace, Danielle; Zhao, Janice; Burack, Richard; Bennett, John M.

doi:10.1007/s12308-021-00469-1

Cited by 1 publication

(2 citation statements)

References 17 publications

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“…Like the microgranular subtype of APL, CD2 is positive in the subtype with basophilic cells. In addition, APL with basophil differentiation, with blasts containing large basophilic granules, has been described [19,66]. Aberrations of the 12p13 locus-in addition to t(15;17)(q22;q11-12)-have been described in M3b [19,66].…”

Section: Acute Mast-cell Leukemiamentioning

confidence: 99%

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Approach to Acute Myeloid Leukemia with Increased Eosinophils and Basophils

Papadakis,

Liapis,

Papadhimitriou

et al. 2024

JCM

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There is remarkable morphologic and genetic heterogeneity in acute myeloid leukemia (AML). In a small percentage of cases of AML, increased eosinophils and/or basophils are present in the bone marrow and sometimes in the peripheral blood. This is often a puzzling diagnostic situation but also an important finding that requires special investigation. Unique chromosomal rearrangements have been correlated with an increased number of eosinophils and basophils in AML. The identification of the underlying genetic lesion that promotes eosinophilia and basophilia can dramatically change both the prognosis and the treatment of the patient. Thus, clinicians must be vigilant in searching for the cause of eosinophilia and basophilia in patients with AML, since the different causes may lead to different treatments and survival outcomes. In this article, we examine the significance of increased eosinophils and/or basophils in the context of AML, provide guidance that simplifies the differential diagnosis, and give prognostic and therapeutic information about specific subtypes of AML associated with eosinophilia and/or basophilia. Evidence supporting personalized (molecularly targeted) therapy for these patients is also presented.

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Section: Acute Mast-cell Leukemiamentioning

confidence: 99%

“…In addition, APL with basophil differentiation, with blasts containing large basophilic granules, has been described [19,66]. Aberrations of the 12p13 locus-in addition to t(15;17)(q22;q11-12)-have been described in M3b [19,66]. Relapse of APL after all-trans retinoic acid (ATRA) therapy with M3b morphology may occur.…”

Section: Acute Mast-cell Leukemiamentioning

confidence: 99%