Case of a Large Pedunculated Biliary Cholesterol Polyp With Osseous Metaplasia

Abukhiran, Ibrahim; Jasser, Judy; Farhat, Ilham; Boukhar, Sarag

doi:10.7759/cureus.12357

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2022

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“…They hypothesized that cholesterol itself stimulated the mucosa of the polyp to transform into carcinoma. Although it is not a neoplastic lesion, Abukhiran et al [ 10 ] reported a rare cholesterol polyp with osseous metaplasia. As a few cases of gallbladder carcinoma associated with cholesterol polyp had been reported so far, there is no consensus on the relationship between cholesterol polyp and carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Gallbladder Intramucosal Carcinoma Arising in a Cholesterol Polyp: A Case Report

Sasaki¹,

Kajiwara²,

Ishii³

et al. 2022

Cureus

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Cholesterol polyp is the most common benign disease of gallbladder polyps, and is considered not to be the origin of malignancy. Herein, we report a rare case of a well-differentiated adenocarcinoma arising in a gallbladder cholesterol polyp. A pedunculated mulberry-like gallbladder polyp diagnosed with a cholesterol polyp preoperatively consisted of two distinct components macroscopically: a yellow-whitish lobulated lesion and a brownish irregular lesion. Microscopically, the former revealed to be a cholesterol polyp, but the latter demonstrated a well-differentiated adenocarcinoma. Even if imaging findings suggest a gallbladder cholesterol polyp, it is important to keep in mind that carcinoma can coexist like our case.

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Section: Discussionmentioning

confidence: 99%