Case management of childhood tuberculosis in children's hospitals in Khartoum

Osman, Tarig; Sony, Asma El

doi:10.26719/2014.20.7.442

Cited by 4 publications

(4 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Again some clinician did not follow the childhood tuberculosis diagnosis organogram. Therefore, in this study, the size of the extra-pulmonary case were 678 (62.4%) which is consistent with a study finding of Addis Ababa 52.8% [5, 24].…”

Section: Discussionsupporting

confidence: 92%

“…In this study among total cases who have treatment outcome records 35 (4.2%) children were died and it is higher than retrospective study done in Addis Ababa indicates 2% (5)and study report from Sidama 3% [21]. But, similar with the study done in Sudan 4.3% [24]. This high rate of death could be the region had high magnitude of child under nutrition which is 33% of children were underweight and 11.6% were wasted [27].…”

Section: Discussionsupporting

confidence: 74%

“…The magnitude of all from of Tuberculosis in the age group of 0–5 years old was 330 (30.4%) which was higher than a study done in Addis Ababa 11.4% and Congo 24% [12]. But, lower than the study done in Sudan 46.7% in the age of 0–4 years [24]. This dis similarity could be children in Tigray and Sudan had uncontrolled frequent contact with adult infectious TB patents.…”

Section: Discussionmentioning

confidence: 73%

See 2 more Smart Citations

Epidemiology of childhood tuberculosis and factors associated with unsuccessful treatment outcomes in Tigray, Ethiopia: a ten-year retrospective cross sectional study

et al. 2019

View full text Add to dashboard Cite

BackgroundChildhood TB is an indicator of a recent transmission of the disease in a community and it is estimated to constitute 15–20% of all TB cases in many of developing countries. However, only few studies which dominated by industrial countries were engaged to assess the situation. Therefore, this study was aimed to see epidemiology of childhood TB and factors associated with poor treatment outcome in developing country.MethodUsing retrospective cross-sectional study design; Socio-demographic and clinical data of children aged less than 15 years old, treated for all forms of TB in the past 10 years (2007–2016) was collected from randomly selected eight public hospitals of Tigray. Then, Univariate logistic regression and adjusted multivariate logistic regressions was done to identify variables which had association with unsuccessful treatment outcomes at P-value less than 0.05.ResultIn the past 10 years, a total of 13,345 Tuberculosis cases were observed. Of these, 1086 (8.1%) cases were children aged less than 15 years old. Sixty seven (6.2%) cases were smear positive. Among those that tested for HIV, 69 (8.3%) cases were TB/HIV co-infected. Of those with treatment outcome record 746 (88.7%) were successfully treated. Factors like being female (AOR, 1.79; 95% CI, 1.07–3.00), Age 0–5 years (AOR, 3.35; 95% CI, 2.11–5.33), Unknown HIV status (AOR, 2.44; 95% CI, 1.51–3.95) and pulmonary positive case (AOR, 2.56; 95% CI, 1.13–5.77), were more likely to have unsuccessful treatment outcome than their counterparts.ConclusionIn Tigray 8.1% all TB cases were children age less than 15 years old. Childhood TB treatment outcome varied with sex, age and HIV status.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 73%

See 1 more Smart Citation

Epidemiology of childhood tuberculosis and factors associated with unsuccessful treatment outcomes in Tigray, Ethiopia: a ten-year retrospective cross sectional study

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Despite these difficulties, 70% of patients completed their treatment at UCK; this rate was higher than that reported in Botswana [ 36 ] or Malawi [ 35 ] but lower than that in other studies in Africa that showed higher treatment success rates [ 34 , 44 ]. In fact, 10.8% of our patients failed defaulted, or died, suggesting poor case management and an inadequate control program for childhood TB.…”

Section: Discussionmentioning

confidence: 60%

Childhood Tuberculosis in a Sub-Saharan Tertiary Facility: Epidemiology and Factors Associated with Treatment Outcome

et al. 2016

View full text Add to dashboard Cite

Childhood tuberculosis (TB) is a diagnostic challenge in developing countries, and patient outcome can be influenced by certain factors. We report the disease course, clinical profile and factors associated with treatment outcome in a tertiary facility of Kinshasa. Documentary and analytical studies were conducted using clinical and exploratory data for children aged up to 15 years who were admitted to the University Clinics of Kinshasa for TB. Data are presented as frequencies and averages, and binary and logistic regression analyses were performed. Of 283 children with TB, 82 (29.0%) had smear-negative TB, 40 (14.1%) had smear-positive TB, 159 (56.1%) had extra-pulmonary TB (EPTB), 2 (0.7%) had multidrug-resistant TB (MDR-TB), 167 (59.0%) completed treatment, 30 (10.6%) were cured, 7 (2.5%) failed treatment, 4 (1.4%) died, 55 (19.4%) were transferred to health centers nearest their home, and 20 (7.0%) were defaulters. In the binary analysis, reported TB contacts (p = 0.048), type of TB (p = 0.000), HIV status (p = 0.050), Ziehl-Nielsen test result (p = 0.000), Lowenstein culture (p = 0.004) and chest X-ray (p = 0.057) were associated with outcome. In the logistic regression, none of these factors was a significant predictor of outcome. Tertiary level care facilities must improve the diagnosis and care of patients with childhood TB, which justifies the development of alternative diagnostic techniques and the assessment of other factors that potentially affect outcome.

show abstract