Case Fatality Rate Related to Microcephaly Congenital Zika Syndrome and Associated Factors: A Nationwide Retrospective Study in Brazil †

Costa, M. C.; Cardim, Luciana Lobato; Teixeira, Maria Glória; Barreto, Maurício Lima; Barreto, Florisneide Rodrigues; Carvalho, Martha Suely Itaparica; Oliveira, Wanderson Kleber de; França, Giovanny Vinícius Araújo de; Carmo, Eduardo Hage; Andrade, Roberto F. S.; Vilela, Mirella Bezerra Rodrigues; Veiga, Rafael Valente; Oliveira, Juliane F.; Fernandes, Qeren Hapuk Rodrigues Ferreira; Costa, Larissa C.; Coelho, Giovanini Evelim; Paixão, Enny S.

doi:10.3390/v12111228

Cited by 20 publications

(23 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Numerous cases of congenital Zika syndrome (CZS) including microcephaly, due to arrested development of the cerebral cortex [59], brain calcifications, intrauterine growth restriction and fetal death have been reported during the 2013 Polynesian and 2015 Brazilian epidemics and among imported cases all over the world [9,59]. The case fatality rate for microcephalic infants is estimated to be around 10%, with the worst outcomes seen in late preterm and/or low birth weight newborn [60,61].…”

Section: Zika Virus Transmission and Clinical Outcomesmentioning

confidence: 99%

Apoptosis During ZIKA Virus Infection: Too Soon or Too Late?

Turpin¹,

Safadi²,

Lebeau³

et al. 2021

Preprint

View full text Add to dashboard Cite

Cell death by apoptosis is a major cellular response, in the control of tissue homeostasis and as a defense mechanism in case of cellular aggression like an infection. Cell self-destruction is part of antiviral responses, aimed at limiting the spread of a virus. Although it may contribute to the deleterious effects in infectious pathology, apoptosis remains a key mechanism for viral clearance and resolution of infection. The control mechanisms of cell death processes by viruses have been extensively studied. Apoptosis can be triggered by different viral determinants, through different pathways, as a result of virally induced cell stresses and innate immune responses. Zika virus (ZIKV) induces Zika disease in humans which has caused severe neurological forms, birth defects and microcephaly in newborns during the last epidemics. ZIKV also surprised by revealing an ability to persist in the genital tract and in semen, thus being sexually transmitted. Mechanisms of diverting antiviral responses such as the interferon response, the role of cytopathic effects and apoptosis in the etiology of the disease have been widely studied and debated. In this review, we examined the interplay between ZIKV infection of different cell types and apoptosis and how the virus deals with this cellular response. We illustrate a duality in the effects of ZIKV-controlled apoptosis, depending on whether it occurs too early or too late, respectively in neuropathogenesis, or in long-term viral persistence. We further discuss a prospective role for apoptosis in ZIKV-related therapies, and the use of ZIKV as an oncolytic agent.

show abstract

Section: Zika Virus Transmission and Clinical Outcomesmentioning

confidence: 99%

Apoptosis During ZIKA Virus Infection: Too Soon or Too Late?

Turpin¹,

Safadi²,

Lebeau³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Numerous cases of congenital Zika syndrome (CZS) including microcephaly due to arrested development of the cerebral cortex [59], brain calcifications, intrauterine growth restriction, and fetal death were reported during the 2013 Polynesian and 2015 Brazilian epidemics and among imported cases all over the world [9,59]. The case fatality rate for microcephalic infants is estimated to be around 10%, with the worst outcomes seen in late preterm and/or low birth weight newborns [60,61].…”

Section: Zika Virus Transmission and Clinical Outcomesmentioning

confidence: 99%

Apoptosis during ZIKA Virus Infection: Too Soon or Too Late?

Turpin

Safadi

Lebeau

et al. 2022

IJMS

View full text Add to dashboard Cite

Cell death by apoptosis is a major cellular response in the control of tissue homeostasis and as a defense mechanism in the case of cellular aggression such as an infection. Cell self-destruction is part of antiviral responses, aimed at limiting the spread of a virus. Although it may contribute to the deleterious effects in infectious pathology, apoptosis remains a key mechanism for viral clearance and the resolution of infection. The control mechanisms of cell death processes by viruses have been extensively studied. Apoptosis can be triggered by different viral determinants through different pathways as a result of virally induced cell stresses and innate immune responses. Zika virus (ZIKV) induces Zika disease in humans, which has caused severe neurological forms, birth defects, and microcephaly in newborns during the last epidemics. ZIKV also surprised by revealing an ability to persist in the genital tract and in semen, thus being sexually transmitted. Mechanisms of diverting antiviral responses such as the interferon response, the role of cytopathic effects and apoptosis in the etiology of the disease have been widely studied and debated. In this review, we examined the interplay between ZIKV infection of different cell types and apoptosis and how the virus deals with this cellular response. We illustrate a duality in the effects of ZIKV-controlled apoptosis, depending on whether it occurs too early or too late, respectively, in neuropathogenesis, or in long-term viral persistence. We further discuss a prospective role for apoptosis in ZIKV-related therapies, and the use of ZIKV as an oncolytic agent.

show abstract

“…12 Additionally, evidence from a nationwide retrospective study linking routinely collected data in Brazil from 2015 to 2017 reported a case fatality rate of 9.4% (95% CI: 8.4% to 10.6%) among children with confirmed CZS diagnoses, with more than 90% of deaths occurring in infancy. 13 …”

Section: Considerations For Assessing a Prenatal Screening Programme For Zikv Infectionmentioning

confidence: 99%

Epidemic preparedness: Prenatal Zika virus screening during the next epidemic

et al. 2021

View full text Add to dashboard Cite

Zika virus (ZIKV) is a vectorborne infectious agent of global public health significance due to its potential to cause severe teratogenic outcomes. The question of whether health systems should consider adopting screening programmes for ZIKV infections during pregnancy warrants consideration. In this analysis, we apply the Wilson-Jungner framework to appraise the potential utility of a prenatal ZIKV screening programme, outline potential screening strategies within the case-finding pathway, and consider other epidemiological factors that may influence the planning of such a screening programme. Our evaluation of a potential prenatal ZIKV screening programme highlights factors affirming its usefulness, including the importance of Congenital Zika Syndrome as a public health problem and the existence of analogous congenital prenatal screening programmes for STORCH agents (syphilis, toxoplasmosis, others (eg, human immunodeficiency virus, varicella-zoster virus, parvovirus B19), rubella, cytomegalovirus, and herpes simplex virus). However, our assessment also reveals key barriers to implementation, such as the need for more accurate diagnostic tests, effective antiviral treatments, increased social service capacity, and surveillance. Given that the reemergence of ZIKV is likely, we provide a guiding framework for policymakers and public health leaders that can be further elaborated and adapted to different contexts in order to reduce the burden of adverse ZIKV-related birth outcomes during future outbreaks.

show abstract

Case Fatality Rate Related to Microcephaly Congenital Zika Syndrome and Associated Factors: A Nationwide Retrospective Study in Brazil †

Cited by 20 publications

References 25 publications

Apoptosis During ZIKA Virus Infection: Too Soon or Too Late?

Apoptosis During ZIKA Virus Infection: Too Soon or Too Late?

Apoptosis during ZIKA Virus Infection: Too Soon or Too Late?

Epidemic preparedness: Prenatal Zika virus screening during the next epidemic

Contact Info

Product

Resources

About