Case-control study: Soft-tissue sarcomas and exposure to phenoxyacetic acids or chlorophenols

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Summary An association between malignant lymphoma (both Hodgkin's disease (HD) and non-Hodgkin lymphoma) and exposure to organic solvents, phenoxy acids, or chlorophenols was previously reported. A reanalysis of this investigation regarding the cases with HD and exposure to various chemicals was performed and resulted in comparable findings to the whole group of malignant lymphoma. There was an overrepresentation of cases with primary involvement of the gastrointestinal tract which was associated with exposure to these chemicals. The influence of previous diseases and socioeconomic factors was analysed through a supplementary questionnaire to the cases with HD and their matched controls. No differences were found in cases and controls for such variables except for tonsillectomy which was overrepresented among the cases as well as a history of previous duodenal or ventricular ulceration. These findings were, however, insignificant.

“…Hardell & Sandstrom, 1979). Good agreement was found between statements from the examined persons about exposure to chlorophenols and the employers which was also the case in this study.…”

Section: Methodssupporting

confidence: 83%

Epidemiological study of socioeconomic factors and clinical findings in Hodgkin's disease, and reanalysis of previous data regarding chemical exposure

Hardell¹,

Bengtsson²

1983

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“…This clinical observation initiated a case-control study to see if there was a possible relationship between this type of tumour and exposure to various agents, including phenoxy acids. Exposure to phenoxy acids or chlorophenols, which are chemically related, was found to be associated with about a 6-fold increase in risk for soft-tissue sarcomas in this study (Hardell & Sandstrom, 1979). Most of the cases exposed to phenoxy acids had been exposed to 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) which, like chlorophenols, can be contaminated by polychlorinated dibenzodioxins (PCDDs) and dibenzofurans (PCDFs).…”

mentioning

confidence: 70%

Malignant lymphoma and exposure to chemicals, especially organic solvents, chlorophenols and phenoxy acids: a case-control study

Hardell¹,

Eriksson²,

Lenner³

et al. 1981

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392

149

A number of men with malignant lymphoma of the histiocytic type and previous exposure to phenoxy acids or chlorophenols were observed and reported in 1979. A matched case-control study has therefore been performed with cases of malignant lymphoma (Hodgkin's disease and non-Hodgkin lymphoma). This study included 169 cases and 338 controls. The results indicate that exposure to phenoxy acids, chlorophenols, and organic solvents may be a causative factor in malignant lymphoma. Combined exposure of these chemicals seemed to increase the risk. Exposure to various other agents was not obviously different in cases and in controls.

“…This, however, accords with the observation from the Swedish case-control studies. In the study from Northern Sweden 5 out of 13 exposed cases had worked with phenoxy herbicides for 3 months or less (Hardell & Sandstr0m, 1979). One of the patients in the cohort ran a small farm beside his work at the plant, making additional exposure during spraying possible.…”

Section: Discussionmentioning

confidence: 99%

A follow-up study of cancer incidence among workers in manufacture of phenoxy herbicides in Denmark

Lynge¹

1985

128