Case-Control Study of Six Genes Asymmetrically Expressed in the Two Cerebral Hemispheres: Association of BAIAP2 with Attention-Deficit/Hyperactivity Disorder

Ribasés, Marta; Bosch, Rosa; Hervás, Amaia; Ramos-Quiroga, Josep Antoni; Sánchez-Mora, Cristina; Bielsa, Anna; Gastaminza, Xavier; Guijarro, Silvina; Nogueira, Mariana; Gómez-Barros, Núria; Kreiker, Susanne; Groß-Lesch, Silke; Jacob, Christian; Lesch, Klaus‐Peter; Reif, Andreas; Johansson, Stefan; Plessen, Kerstin J.; Knappskog, Per M.; Haavik, Jan; Estivill, Xavier; Casas, Miguel; Bayés, Mònica; Cormand, Bru

doi:10.1016/j.biopsych.2009.06.024

Cited by 59 publications

(55 citation statements)

References 75 publications

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“…Genetic variations in BAIAP2 were also associated with attentiondeficit hyperactivity disorder [35] and autism [36]. A functional neuroimaging study [29] showed that posterior MTL areas were more sensitive to neutral subsequent memory and anterior ones to emotional subsequent memory, which was essentially replicated in our genotype-independent fMRI results (Tableô 3).…”

Section: Discussionsupporting

confidence: 76%

Correction: BAIAP2 Is Related to Emotional Modulation of Human Memory Strength

2014

PLoS ONE

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Memory performance is the result of many distinct mental processes, such as memory encoding, forgetting, and modulation of memory strength by emotional arousal. These processes, which are subserved by partly distinct molecular profiles, are not always amenable to direct observation. Therefore, computational models can be used to make inferences about specific mental processes and to study their genetic underpinnings. Here we combined a computational model-based analysis of memory-related processes with high density genetic information derived from a genome-wide study in healthy young adults. After identifying the best-fitting model for a verbal memory task and estimating the best-fitting individual cognitive parameters, we found a common variant in the gene encoding the brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) that was related to the model parameter reflecting modulation of verbal memory strength by negative valence. We also observed an association between the same genetic variant and a similar emotional modulation phenotype in a different population performing a picture memory task. Furthermore, using functional neuroimaging we found robust genotype-dependent differences in activity of the parahippocampal cortex that were specifically related to successful memory encoding of negative versus neutral information. Finally, we analyzed cortical gene expression data of 193 deceased subjects and detected significant BAIAP2 genotype-dependent differences in BAIAP2 mRNA levels. Our findings suggest that model-based dissociation of specific cognitive parameters can improve the understanding of genetic underpinnings of human learning and memory.

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Section: Discussionsupporting

confidence: 76%

Correction: BAIAP2 Is Related to Emotional Modulation of Human Memory Strength

2014

PLoS ONE

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“…Several genes encoding neurotrophic factors and their receptors have been associated with ADHD (Ribases et al, 2008). In addition, previous lines of evidence supported a relationship between neurodevelopmental genes, characterized by an asymmetric expression in brain hemispheres, and vulnerability to ADHD (Ribases et al, 2009). Among these, adult ADHD was significantly associated with a haplotype constituted of two single nucleotide polymorphism markers, rs7210438 and rs8079626 (Ribases et al, 2009), located in BAIAP2 (brain-specific angiogenesis inhibitor 1-associated protein 2), a gene known to be involved in neuronal proliferation, survival and maturation during early development (Knusel et al, 1990;Beck et al, 1993;Russo et al, 2007).…”

Section: Introductionmentioning

confidence: 89%

Inter-hemispherical asymmetry in default-mode functional connectivity and BAIAP2 gene are associated with anger expression in ADHD adults

Hasler

Preti

Meskaldji

et al. 2017

Psychiatry Research: Neuroimaging

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A B S T R A C TAttention deficit hyperactivity disorder (ADHD) is accompanied by resting-state alterations, including abnormal activity, connectivity and asymmetry of the default-mode network (DMN). Concurrently, recent studies suggested a link between ADHD and the presence of polymorphisms within the gene BAIAP2 (i.e., brain-specific angiogenesis inhibitor 1-associated protein 2), known to be differentially expressed in brain hemispheres. The clinical and neuroimaging correlates of this polymorphism are still unknown. We investigated the association between BAIAP2 polymorphisms and DMN functional connectivity (FC) asymmetry as well as behavioral measures in ADHD adults. Resting-state fMRI was acquired from 30 ADHD and 15 healthy adults. For each subject, rs7210438 and rs8079626 within the gene BAIAP2 were genotyped. ADHD severity, impulsiveness and anger were assessed for the ADHD group. Using multivariate analysis of variance, we found that genetic features do have an impact on DMN FC asymmetry. In particular, polymorphism rs8079626 affects medial frontal gyrus and inferior parietal lobule connectivity asymmetry, lower for AA than AG/GG carriers. Further, when combining FC asymmetry and the presence of the rs8079626 variant, we successfully predicted increased externalization of anger in ADHD. In conclusion, a complex interplay between genetic vulnerability and interhemispherical DMN FC asymmetry plays a role in emotion regulation in adult ADHD.

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“…IRSp53 has been implicated also in other psychiatric disorders, including ADHD (attention deficit/hyperactivity disorder) 207,208 and schizophrenia 209,210 . Overexpression of IRSp53 in cultured neurons increases the density of dendritic spines without affecting spine length or width.…”

Section: Accepted Manuscriptmentioning

confidence: 99%