Case-control study of risk factors for hip fractures in the Japanese elderly by a Mediterranean osteoporosis study (MEDOS) questionnaire

Suzuki, Takao; Yoshida, Hideyo; Hashimoto, Toshiaki; Yoshimura, Nagahisa; Fujiwara, Saeko; Fukunaga, Masao; Nakamura, Toshio; Yoh, Kazunori; Inoue, Tetsuro; Hosoi, Takayuki; Orimo, Hajime

doi:10.1016/s8756-3282(97)00179-8

Cited by 91 publications

(72 citation statements)

References 53 publications

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“…This finding is consistent with those of other investigations (Suzuki et al, 1997;Feskanich et al, 2003) even though, null associations have also been reported (Appleby et al, 2007). Fish (especially dark meat fish) constitute good sources of calcium (especially when edible bones are consumed) and vitamin D. Moreover, they are rich in o-3 fatty acids.…”

Section: Discussionsupporting

confidence: 93%

Diet and hip fractures among elderly Europeans in the EPIC cohort

et al. 2010

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Background/Objectives: Evidence on the role of diet during adulthood and beyond on fracture occurrence is limited. We investigated diet and hip fracture incidence in a population of elderly Europeans, participants in the European Prospective Investigation into Cancer and nutrition study. Subjects/Methods: 29 122 volunteers (10 538 men, 18 584 women) aged 60 years and above (mean age: 64.3) from five countries were followed up for a median of 8 years and 275 incident hip fractures (222 women and 53 men) were recorded. Diet was assessed at baseline through validated dietary questionnaires. Data were analyzed through Cox proportional-hazards regression with adjustment for potential confounders. Results: No food group or nutrient was significantly associated with hip fracture occurrence. There were suggestive inverse associations, however, with vegetable consumption (hazard ratio (HR) per increasing sex-specific quintile: 0.93, 95% confidence interval (CI): 0.85-1.01), fish consumption (HR per increasing sex-specific quintile: 0.93, 95% CI: 0.85-1.02) and polyunsaturated lipid intake (HR per increasing sex-specific quintile: 0.92, 95% CI: 0.82-1.02), whereas saturated lipid intake was positively associated with hip fracture risk (HR per increasing sex-specific quintile: 1.13, 95% CI: 0.99-1.29). Consumption of dairy products did not appear to influence the risk (HR per increasing sex-specific quintile: 1.02, 95% CI: 0.93-1.12). Conclusions: In a prospective study of the elderly, diet, including consumption of dairy products, alcohol and vitamin D, did not appear to play a major role in hip fracture incidence. There is however, weak and statistically non-significant evidence that vegetable and fish consumption and intake of polyunsaturated lipids may have a beneficial, whereas saturated lipid intake a detrimental effect.

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Section: Discussionsupporting

confidence: 93%

Diet and hip fractures among elderly Europeans in the EPIC cohort

et al. 2010

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“…Eight of 13 studies that examined the association between alcohol consumption and risk of hip fracture were prospective cohort studies, [33][34][35][36][37][38][39][40] and 5 were case-control studies 21,31,32,41,42 (Table 1). The case-control studies compared hospitalized cases with community controls, 21,32,41 hospitalized controls, 42 or both.…”

Section: Alcohol Consumption and Hip Fracture Riskmentioning

confidence: 99%

Section: Alcohol Consumption and Hip Fracture Riskmentioning

confidence: 99%

“…The case-control studies compared hospitalized cases with community controls, 21,32,41 hospitalized controls, 42 or both. 31 Cases and controls were matched on age, sex, race or ethnicity, and residential area, 31,32 or geographic location only. 21,41,42 Meta-analysis of the effect of alcohol consumption on hip fracture risk revealed a J-shaped relationship, which is illustrated in Figure 2.…”

Section: Alcohol Consumption and Hip Fracture Riskmentioning

confidence: 99%

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Association Between Alcohol Consumption and Both Osteoporotic Fracture and Bone Density

Berg

Kunins

Jackson

et al. 2008

The American Journal of Medicine

274

197

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“…These include retrospective case-control studies comparing characteristics of hip fracture patients with age-and sex-matched control subjects, [2][3][4][5][6][7][8][9][10][11][12] prospective cohort studies of population samples followed up to identify subsequent hip fractures, [13][14][15][16] and cross-sectional studies in which questionnaires were sent to large numbers of people to ascertain how often stroke and hip fractures occur in the same individual. 17,18 These suggest, with only 1 exception, 14 that stroke is a risk factor for subsequent hip fracture, with most studies reporting risk (or odds) ratios of between 1.5 and 4.…”

mentioning

confidence: 99%

Fractures After Stroke

Dennis

McDowall

et al. 2002

Stroke

164

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Background and Purpose-Stroke patients may have an increased risk of fractures because of weak bones or an increased risk of falling. Our goal was to estimate the frequency of fracture after stroke and to identify those at greatest risk. Methods-This study incorporated 2 complementary strategies: a prospective, single-center, cohort study and an analysis of Scottish routine hospital discharge data. Results-Eighty-eight fractures (30% hip) occurred in 2696 hospital-referred stroke patients. The proportions sustaining any fracture or hip fracture within 2 years were 4% and 1.1%, respectively, 1.4 (95% CI, 0.92 to 2.07) times the rate of hip fracture in the general population (ie, observed number divided by expected number or standardized morbidity ratio). Female sex, older age, low abbreviated mental test score, and prestroke dependence were associated with an increased hip fracture rate. Routine data identified 129 935 acute stroke patients admitted to Scottish hospitals. During 363 447 patient-years, 4528 patients had hip fractures, 2.0% had fractures by 1 year, and 10.6% had fractures by 10 years. This is 1.7 times the rate of hip fracture in the general population and 2.3 times that in patients with myocardial infarction. Older patients predictably had the highest rate of poststroke hip fractures but a lower standardized morbidity ratio than younger patients. Conclusions-Fractures after stroke are probably frequent and serious enough to justify the development of preventive strategies, but the modest event rate would mean that randomized, controlled trials to test these strategies specifically in stroke patients would need to enroll thousands of patients.

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Case-control study of risk factors for hip fractures in the Japanese elderly by a Mediterranean osteoporosis study (MEDOS) questionnaire

Cited by 91 publications

References 53 publications

Diet and hip fractures among elderly Europeans in the EPIC cohort

Diet and hip fractures among elderly Europeans in the EPIC cohort

Association Between Alcohol Consumption and Both Osteoporotic Fracture and Bone Density

Fractures After Stroke

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