Case-control study of risk factors for acute corneal hydrops in keratoconus

Barsam, Allon; Brennan, Nic; Petrushkin, Harry; Xing, Wen; Quartilho, Ana; Bunce, Catey; Foot, B; Cartwright, Nathaniel Knox; Haridas, Anjana; Agrawal, Pavi; Suleman, Hanif; Ahmad, Sajjad; Macdonald, Elisabeth; Johnston, Jennifer; Tuft, Stephen

doi:10.1136/bjophthalmol-2015-308251

Cited by 19 publications

(32 citation statements)

References 24 publications

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“…Table 2. The most serious ophthalmic complications in AD patients Corneal hydrops [37,63] Infection after ophthalmic procedure [42,43] Retinal detachment [44,49] IOL subluxation [50,56]…”

Section: Discussionmentioning

confidence: 99%

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Ophthalmic manifestations of atopic dermatitis

Pietruszyńska¹,

Zawadzka-Krajewska²,

Duda³

et al. 2020

pdia

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Atopic dermatitis is a chronic condition of complex etiology, whose clinical course involves remission and recurrence. It is not an isolated disease entity affecting only the skin, but one that co-occurs with disorders of other organs. Numerous literature reports have long confirmed the relationship between the disorder and a growing number of ophthalmic manifestations such as keratoconus and retinal detachment. Further studies are required to establish the cause of correlations and to allow for implementation of appropriate prophylaxis and treatment. The aim of the present paper is to review published literature regarding the correlation between atopic dermatitis and ophthalmic manifestations in adults and children.

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“…Table 2. The most serious ophthalmic complications in AD patients Corneal hydrops [37,63] Infection after ophthalmic procedure [42,43] Retinal detachment [44,49] IOL subluxation [50,56]…”

Section: Discussionmentioning

confidence: 99%

“…Some allergic conditions (vernal keratoconjunctivitis, asthma, atopic dermatitis) are strongly associated with acute corneal hydrops in keratoconus, and patients with them should be examined regularly [37].…”

Section: Advances In Dermatology and Allergology 2 April / 2020mentioning

confidence: 99%

Ophthalmic manifestations of atopic dermatitis

Pietruszyńska¹,

Zawadzka-Krajewska²,

Duda³

et al. 2020

pdia

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“…14 Chronic eye rubbing contributes to the development of keratoconus and other corneal ectasias. [15][16][17] In severe cases, a corneal ulcer (shield ulcer) might be visible, which stains with fluorescein ( fig 2⇓).…”

Section: Rarer Causesmentioning

confidence: 99%

Allergic eye disease

Patel

Arunakirinathan

Stuart

et al. 2017

BMJ

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“…The condition results in keratoconus, or anterior bulging of the cornea and can be vision-or globe-threatening if not managed appropriately. Acute corneal hydrops is reported in humans and cats and is caused by localised rupture of Descemet's membrane (Dubielzig et al 2010;Fan Gaskin et al 2013;Barsam et al 2017;Schlesener et al 2018), allowing ingress of aqueous humour with rapid and progressive corneal hydration. Risk factors have been suggested in humans (pre-existing ectatic corneal disease, trauma) (Grewal et al 2000;Barsam et al 2017) and cats (systemic cyclosporine administration) (Pierce et al 2016), but the disease is still poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Acute corneal hydrops of presumed traumatic origin: An uncontrolled case series (three horses)

O'Leary

Sebbag

Moody

et al. 2021

Equine Veterinary Education

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This case series describes acute corneal hydrops in three young horses. Due to similarities in the clinical appearance and progression of the disease with that which is reported in humans and cats with acute corneal hydrops, traumatic Descemet's membrane rupture was suspected to be the underlying aetiology in these equine cases. The horses presented with acute severe corneal oedema with intrastromal bullae formation and anterior bulging of the corneal contour. Focal posterior corneal changes were also seen in two of three cases. Mild anterior uveitis was also present. Other causes of corneal oedema (e.g. glaucoma) were ruled out based on presentation and clinical examination. Treatment approaches were medical and included various combinations of prophylactic topical antimicrobial therapy in case of secondary corneal ulceration, anti-inflammatory therapy for uveitis, targeted oedema therapy with topical hypertonic saline and corneal cross-linking, and placement of a temporary partial tarsorrhaphy for corneal tamponade. The outcome was excellent in all cases, with rapid resolution of the ocular changes. Acute corneal hydrops of presumed traumatic Descemet's membrane rupture origin should be considered in cases of young horses presenting with acute corneal oedema. However, further studies are warranted to better characterise the disease and to try to confirm the suspected aetiology.

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Case-control study of risk factors for acute corneal hydrops in keratoconus

Abstract: Some individuals with keratoconus are at high risk of developing acute corneal hydrops. These patients could be managed more aggressively to reduce their risk of developing this complication of their disease.

Cited by 19 publications

References 24 publications

Ophthalmic manifestations of atopic dermatitis

Ophthalmic manifestations of atopic dermatitis

Allergic eye disease

Acute corneal hydrops of presumed traumatic origin: An uncontrolled case series (three horses)

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