Case–Control Study of Overweight, Obesity, and Colorectal Cancer Risk, Overall and by Tumor Microsatellite Instability Status

Campbell, Peter T.; Jacobs, Elizabeth T.; Ulrich, Cornelia M.; Figueiredo, Jane C.; Poynter, Jenny N.; McLaughlin, John; Haile, Robert W.; Jacobs, Eric J.; Newcomb, Polly A.; Potter, John D.; Marchand, Loı̈c Le; Green, Roger C.; Parfrey, Patrick S.; Younghusband, H. Banfield; Cotterchio, Michelle; Gallinger, Steven; Jenkins, Mark A.; Hopper, John L.; Baron, John A.; Thibodeau, Stephen N.; Lindor, Noralane M.; Limburg, Paul J.; Martı́nez, Marı́a Elena

doi:10.1093/jnci/djq011

Cited by 163 publications

(165 citation statements)

References 37 publications

(43 reference statements)

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“…Some have hypothesized that this finding may reflect differences in environmental and lifestyle factors between Latinos and other populations. For example, MSI-H CRC has been associated with tobacco use 36, 38 , which is less prevalent in Latinos compared to other populations 39 ; and high body-mass-index, which is more common in Latinos, is associated with microsatellite stable CRC tumors 40 . Further studies are needed to investigate these hypotheses.…”

Section: Discussionmentioning

confidence: 99%

DNA mismatch repair deficiency and hereditary syndromes in Latino patients with colorectal cancer

Ricker

Hanna

Peng

et al. 2017

Cancer

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Background The landscape of hereditary syndromes and clinicopathologic characteristics among U.S. Latinos/Hispanics with colorectal cancer (CRC) remains poorly understood. Methods A total of 265 CRC patients enrolled in the Hispanic Colorectal Cancer Study were included in this study. Information regarding CRC risk factors was elicited through interviews, and treatment and survival data was abstracted from clinical charts. Tumor studies and germline genetic testing results were collected from medical records or performed using standard molecular methods. Results The mean age at diagnosis was 53.7 years (SD=10.3), and 48.3% were female. Overall, 21.2% reported a first- or second-degree relative with CRC; 3.4% met Amsterdam I/II criteria. With respect to Bethesda guidelines, 38.5% met at least one criterion. Of the 161 individuals who had immunohistochemistry (IHC) and/or microsatellite instability (MSI) testing performed, 21 (13.0%) had mismatch repair (MMR) deficient tumors. dMMR tumors were associated with female sex (61.9%), earlier age of diagnosis (50.4 ± 12.4 years), proximal location (61.9%), and first (23.8%) or second (9.5%) degree family history of CRC. Among individuals with dMMR tumors, 13 (61.9%) had a germline MMR mutation (MLH1=6, MSH2=4, MHS6=2, and PMS2=1). We identified two additional MLH1 mutation carriers by genetic testing who had not received IHC/MSI testing. In total, 5.7% of the entire cohort were confirmed cases of Lynch syndrome. Additionally, six individuals (2.3%) had a polyposis phenotype. Conclusions The proportion of dMMR tumors in Latinos (13%) is similar to estimates in non-Hispanic Whites. The majority of individuals with dMMR tumors were confirmed to have Lynch syndrome.

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Section: Discussionmentioning

confidence: 99%

DNA mismatch repair deficiency and hereditary syndromes in Latino patients with colorectal cancer

Ricker

Hanna

Peng

et al. 2017

Cancer

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“…Increasingly, risk exposure is linked with specific molecular signatures-for example, BMI is associated with increased risk of postmenopausal breast cancer [41], but we now appreciate that this is in the main limited to oestrogen receptor/progesterone receptor positive breast tumours [75,76]. Similarly, BMI is associated with increased risk of colon cancer [41], but this is mainly linked to microsatellite stable tumours [77]. These molecular types in turn have distinct natural histories.…”

Section: Differences In Tumour Biologymentioning

confidence: 99%

Diabetes and cancer (2): evaluating the impact of diabetes on mortality in patients with cancer

et al. 2012

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In this paper we address methodological aspects of aetiological importance in the link between diabetes and mortality in patients with cancer. We identified nine key points on the cancer pathway at which confounding may arise-cancer screening use, stage at diagnosis, cancer treatment selection, cancer treatment complications and failures, peri-treatment mortality, competing risks for long-term mortality, effects of type 2 diabetes on anti-cancer therapies, effects of glucoselowering treatments on cancer outcome and differences in tumour biology. Two types of mortality studies were identified: (1) inception cohort studies that evaluate the effect of baseline diabetes on cancer-related mortality in general populations, and (2) cohorts of patients with a cancer diagnosis and preexisting type 2 diabetes. We demonstrate, with multiple examples from the literature, that pre-existing diabetes affects presentation, cancer treatment, and outcome of several common cancer types, often to varying extents. Diabetes is associated with increased all-cause mortality in cancer patients, but the evidence that it influences cancer-specific mortality is inconsistent. In the absence of data that address the potential biases and confounders outlined in the above framework, we caution against the reporting of cancer-related mortality as a main endpoint in analyses determining the impact of diabetes and glucose-lowering medications on risk of cancer.

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“…Recent findings from MPE studies suggest that associations of obesity and smoking with colorectal cancer risk differ by tumor MSI or CIMP (4)(5)(6)(7)(8). Motivated, in part, by these findings, we sought to establish a repository of colorectal tissue specimens from participants enrolled in the Cancer Prevention Study-II (CPS-II) Nutrition Cohort.…”

Section: Introductionmentioning

confidence: 99%

Establishment of the Cancer Prevention Study II Nutrition Cohort Colorectal Tissue Repository

Campbell

Deka

Briggs

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: To better understand colorectal cancer etiology and prognosis, archived surgical tissues were collected from Cancer Prevention Study II (CPS-II) Nutrition Cohort participants who were diagnosed with colorectal cancer. Herein, the methodology for this collection is described to help inform other efforts to collect tissues.Methods: The main components to accruing tissue were: (i) obtaining consent from participants or next-ofkin; (ii) contacting hospitals to request materials; and (iii) pathology review and laboratory processing.

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Case–Control Study of Overweight, Obesity, and Colorectal Cancer Risk, Overall and by Tumor Microsatellite Instability Status

Abstract: The increased risk of colorectal cancer associated with a high BMI might be largely restricted to tumors that display the more common MS-stable phenotype, suggesting further that colorectal cancer etiology differs by tumor MSI status.

Cited by 163 publications

References 37 publications

DNA mismatch repair deficiency and hereditary syndromes in Latino patients with colorectal cancer

DNA mismatch repair deficiency and hereditary syndromes in Latino patients with colorectal cancer

Diabetes and cancer (2): evaluating the impact of diabetes on mortality in patients with cancer

Establishment of the Cancer Prevention Study II Nutrition Cohort Colorectal Tissue Repository

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