Case–control study of household contacts to examine immunological protection from<i>Bordetella pertussis</i>transmission — study protocol

We conducted a systematic review to describe the frequency of mild, atypical, and asymptomatic infection among household contacts of pertussis cases and to explore the published literature for evidence of asymptomatic transmission. We included studies that obtained and tested laboratory specimens from household contacts regardless of symptom presentation and reported the proportion of cases with typical, mild/atypical, or asymptomatic infection. After screening 6789 articles, we included 26 studies. Fourteen studies reported household contacts with mild/atypical pertussis. These comprised up to 46.2% of all contacts tested. Twenty-four studies reported asymptomatic contacts with laboratory-confirmed pertussis, comprising up to 55.6% of those tested. Seven studies presented evidence consistent with asymptomatic pertussis transmission between household contacts. Our results demonstrate a high prevalence of subclinical infection in household contacts of pertussis cases, which may play a substantial role in the ongoing transmission of disease. Our review reveals a gap in our understanding of pertussis transmission.

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Asymptomatic Infection and Transmission of Pertussis in Households: A Systematic Review

Craig

Kunkel

Crowcroft

et al. 2019

Clinical Infectious Diseases

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Case–control study of household contacts to examine immunological protection fromBordetella pertussistransmission — study protocol

Abstract: The results of this study will be essential for understanding the immune response required for protection from infection with and will contribute to our understanding of the shortcomings of the current vaccine.

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Asymptomatic Infection and Transmission of Pertussis in Households: A Systematic Review

Asymptomatic Infection and Transmission of Pertussis in Households: A Systematic Review

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