Case–control study of green tea consumption and the risk of endometrial endometrioid adenocarcinoma

Kakuta, Yukika; Nakaya, Naoki; Nagase, Satoru; Fujita, Megumi; Koizumi, Takahisa; Okamura, Chikako; Niikura, Hitoshi; Ohmori, Kenji; Kuriyama, Shinichi; Tase, Toru; Itō, Kiyoshi; Minami, Yuko; Yaegashi, Nobuo; Tsuji, Ichiro

doi:10.1007/s10552-008-9272-0

Cited by 30 publications

(18 citation statements)

References 24 publications

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“…Of these studies, three were conducted in Japan [21-23] and two in China [16, 24]. It can be presumed that green tea was the main tea type consumed in these populations.…”

Section: Endometrial Cancermentioning

confidence: 99%

Green and black tea in relation to gynecologic cancers

Butler

2011

Molecular Nutrition Food Res

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Scope Observational studies have evaluated the relationship between green tea intake and cancers of the ovary and endometrium, but we are not aware of the published studies on green tea intake and risk of human papillomavirus (HPV)-related cancers of the cervix, vagina, or vulva. Methods and results A critical review of the published literature on tea intake and risk of ovarian and endometrial cancers was conducted. In meta-analyses, we report inverse associations for green tea intake and risk of ovarian cancer (odds ratio [OR] = 0.66; 95% confidence interval [CI]: 0.54, 0.80), and for green tea and risk of endometrial cancer (OR = 0.78, 95% CI: 0.62, 0.98). There was no association for black tea and ovarian cancer risk (OR = 0.94, 95% CI: 0.87, 1.02) and a positive association with endometrial cancer risk (OR = 1.20, 95% CI: 1.05, 1.38). We summarized the experimental evidence supporting the antiviral and immunomodulatory activities of green tea catechins, and results from randomized clinical trials that demonstrated green tea catechin efficacy on treatment of cervical lesions and external genital warts. Conclusion Observational data support a protective role of green tea on risk of ovarian and endometrial cancers. Observational data are needed to evaluate whether green tea reduces risk of human papillomavirus-related cancers.

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“…Of these studies, three were conducted in Japan [21-23] and two in China [16, 24]. It can be presumed that green tea was the main tea type consumed in these populations.…”

Section: Endometrial Cancermentioning

confidence: 99%

Green and black tea in relation to gynecologic cancers

Butler

2011

Molecular Nutrition Food Res

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“…In a small cohort study following 254 women with diagnosed epithelial ovarian cancer over 3 years demonstrated that habitual green tea consumption caused a significant dose-dependent increase in survival rate (Zhang et al, 2004). Kakuta et al (2009) demonstrated a reduction in the risk of developing endometrial endometriod adenocarcinoma with habitual green tea consumption in a case-control study which included 437 women. A reduction in the risk for the development was observed for all subtypes of adult leukemia associated with the habitual high intake of green tea in a small case-control study involving 107 cases and 110 controls (Zhang et al, 2008).…”

Section: Observational Studiesmentioning

confidence: 99%

Can green tea do that? A literature review of the clinical evidence

Clement

2009

Preventive Medicine

120

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“…Yang et al 14 reported that regular intake of GT was shown to provide protection against the development of colorectal cancer in a large cohort of 69,710 Chinese women followed up for 2-3 years. Kakuta et al 22 demonstrated in a case-control study with habitual consumption of GT, which included 437 women, a marked reduction in the risk of developing endometrial endometriod adenocarcinoma. Many scientists have reported 13,23,24 that EGCG, epicatechin gallate, and epigallocatechin are the main constituents of GT extract that have cancer preventive activities, including growth inhibition of human cancer cell lines in cultures, induction of apoptosis, inhibition of tumor promotion and carcinogenesis in animal experiments, antimutagenic and antioxidant activities, inhibition of tumor necrosis factor-a release from cells induced by a tumor promoter, and modulation of gene expression.…”

Section: Introductionmentioning

confidence: 99%

Green Tea, Phytic Acid, and Inositol in Combination Reduced the Incidence of Azoxymethane-Induced Colon Tumors in Fisher 344 Male Rats

Khatiwada

Verghese

Davis

et al. 2011

Journal of Medicinal Food

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Experimental as well as epidemiologic studies in human populations provide evidence that consumption of phytochemicals reduces the incidence of degenerative diseases. Green tea (GT) catechins are known for their antioxidative potential. Phytic acid (PA) also acts as a natural antioxidant and may have numerous health benefits. This experiment was designed to investigate the inhibitory effects of combinations of 1% and 2% GT, PA, and inositol (I) in reducing the incidence of azoxymethane-induced colon tumors in Fisher 344 male rats. After an acclimatization period of 1 week, nine groups of rats (15 rats per group) were initially assigned to consume AIN 93 G diet and later AIN 93 M diet after 20 weeks of age. Treatments were given in drinking water. All rats received azoxymethane injections (16 mg/kg of body weight) subcutaneously at 7 and 8 weeks of age. Rats were killed at 45 weeks of age by CO(2) euthanasia. Tumor incidence (93.76%) and the number of tumors per tumor-bearing rat ratio (2.25) were significantly (P<.05) higher in the control group compared with treatment groups. Glutathione S-transferase activity was significantly (P<.05) higher in rats fed combinations of 2% GT+PA+I and GT+PA (33.25 ± 1.23 and 29.83 ± 1.10 μmol/mL, respectively) compared with other groups. These findings suggest that the synergistic effect of the 2% level of GT, PA, and I may reduce the incidence of colon tumors and therefore have potential as a chemopreventive agent.

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Case–control study of green tea consumption and the risk of endometrial endometrioid adenocarcinoma

Abstract: Green tea consumption may be associated with a lower risk of EEA.

Cited by 30 publications

References 24 publications

Green and black tea in relation to gynecologic cancers

Green and black tea in relation to gynecologic cancers

Can green tea do that? A literature review of the clinical evidence

Green Tea, Phytic Acid, and Inositol in Combination Reduced the Incidence of Azoxymethane-Induced Colon Tumors in Fisher 344 Male Rats

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