Case 44362

Cabot, Richard C.; Castleman, Benjamin; Kibbee, Betty U.

doi:10.1056/nejm195809042591011

Cited by 9 publications

(3 citation statements)

References 8 publications

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“…Because of its rarity, very little data has been published regarding the value of chemotherapy and radiotherapy in the adjuvant or advanced setting. In fact, current therapeutic options are based on an extrapolation from data observed in colon cancer [2, 4, 11]. …”

Section: Discussionmentioning

confidence: 99%

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Small Bowel Adenocarcinoma Complicating Coeliac Disease: A Report of Three Cases and the Literature Review

Benhammane

Mrabet

Serhouchni

et al. 2012

Case Reports in Oncological Medicine

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Coeliac disease is associated with an increased risk of malignancy, not only of intestinal lymphoma but also of small intestinal adenocarcinoma which is 82 times more common in patients with celiac disease than in the normal population. We report three additional cases of a small bowel adenocarcinoma in the setting of coeliac disease in order to underline the epidemiological features, clinicopathological findings, and therapeutic approaches of this entity based on a review of the literature. The three patients underwent a surgical treatment followed by adjuvant chemotherapy based on capecitabine/oxaliplatin regimen, and they have well recovered.

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Section: Discussionmentioning

confidence: 99%

“…The association between coeliac disease (CD) and malignancies is well established with the reported frequency of malignancies ranging from 5% to 21%. SBA in association with CD was first reported in 1958 [4]. Etiology and pathogenic mechanisms have not been well elucidated.…”

Section: Introductionmentioning

confidence: 99%

Small Bowel Adenocarcinoma Complicating Coeliac Disease: A Report of Three Cases and the Literature Review

Benhammane

Mrabet

Serhouchni

et al. 2012

Case Reports in Oncological Medicine

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“…The association between carcinoma of the small bowel and CD was first reported in 1958 [9]. Since then, the association between CD and small bowel carcinoma is persistent although only based on a small number of patients of which the greater part is in the form of case reports.…”

Section: Discussionmentioning

confidence: 99%

Small Bowel Adenocarcinoma in a Patient with Coeliac Disease: Case Report and Review of the Literature

Richir¹,

Songun²,

Wientjes

et al. 2010

Case Rep Gastroenterol

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Coeliac disease (CD) is an autoimmune disorder which leads to chronic inflammation of the gut. Furthermore, CD is associated with upper gastrointestinal malignancies, particularly lymphoma of the small intestine. Besides lymphoma, an increased frequency of associated small bowel carcinoma has been described. Here we report the case of a 70-year-old male suffering from CD who was treated with a gluten-free diet presenting with complaints of nausea, vomiting and weight loss of about 8 kg in two months. He underwent esophagogastroduodenoscopy, which identified distention of the stomach and duodenum and in the pars horizontalis a distinct obstruction was suggestive. However, histopathological examination showed a normal mucosal membrane. Additionally, a computed tomography scan of the abdomen was performed which showed an expanded stomach and duodenum up to the ligament of Treitz. During an explorative laparotomy a small tumor was palpated near the ligament of Treitz. Subsequently, a duodenal segment resection was performed. After surgery, the patient recovered well and left our hospital in good condition.

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