Case 44, part I

Mosby, Edward L.; Albright, Jimmy E.; Messer, Eugene J.; Nealis, Michael F.; Werning, John T.

doi:10.1016/0278-2391(83)90077-0

Cited by 8 publications

(1 citation statement)

References 1 publication

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“…In a broader context, comparing this case with existing literature reveals commonalities, such as the characteristic radiographic appearance and histopathological features of xanthomas [ 25 – 27 ]. However, the uniqueness of this case lies in its rare manifestation in the mandible, necessitating differentiation from other histiocytic lesions.…”

Section: Discussionmentioning

confidence: 88%

Solitary primary intraosseous xanthoma of the mandible in a 15-year-old boy: a case report

Georgiev,

Genova,

Uchikov

et al. 2024

J Med Case Reports

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Background A xanthoma is a rare bone condition consisting of a predominant collection of lipid-rich, foamy histiocytes. The central xanthoma of the jaws is a unique benign tumor. Case report A 15-year-old Caucasian male has been presented to our department. He had radiological changes in the area of the left mandibular angle, with an area of diffuse osteolysis of 3.0 cm by 2.0 cm. Computed tomography reveals an area of diffuse osteolysis that starts from the distal root of the lower second molar and reaches the ascending process. A bone biopsy was performed, which revealed a benign proliferative process composed of histiocytic cells involving and infiltrating trabecular bone in a background of loose fibrous connective tissue devoid of any other significant inflammatory infiltrate. The size of the formation was 2.9 cm by 2.0 cm. Immunohistochemical staining for CD68 was strongly positive and negative for S-100 and CD1a. From routine blood tests, cholesterol, triglycerides, and blood sugar are within normal values, which excludes systemic metabolic disease. Subsequent to the surgical intervention, the patient underwent postoperative assessments at intervals of 14, 30, 60 days, and a year later, revealing the absence of any discernible complications during the aforementioned observation periods. Conclusion The diagnosis of primary xanthoma of the mandible is rare and can often be confused with other histiocytic lesions. A differential diagnosis should be made with nonossifying fibroma and Langerhans cell histiocytosis, as in our case. In these cases, immunohistochemistry with CD 68, S-100, and CD1a, as well as blood parameters, are crucial for the diagnosis.

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Section: Discussionmentioning

confidence: 88%

Solitary primary intraosseous xanthoma of the mandible in a 15-year-old boy: a case report

Georgiev,

Genova,

Uchikov

et al. 2024

J Med Case Reports

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Central Xanthoma of the Jaw Bones: A Benign Tumor

Rawal

Chandra

Hall

2016

Head and Neck Pathol

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Extragnathic xanthomas are seen in the bones or as soft tissue masses. They are often associated with hyperlipidemia and are considered as reactive or metabolic lesions. Only 19 cases of xanthomas of the jaws have been reported so far in the English literature. A total of ten cases of central xanthoma of the jaw bones were identified from the Oral and Maxillofacial Pathology biopsy services of the University of Washington and the Tufts University School of Dental Medicine, between the years 2000-2016. The demographic and clinical information on these cases was tabulated logically on the basis of age, gender, location and presence or absence of symptoms, extragnathic lesions and serum hyperlipidemia. Radiographic and histopathological features were also examined. The findings in these cases were correlated with those available from the previously reported cases. Majority of cases are seen in the second and third decades of life. There is no gender predilection. Jaw lesions presented as solitary radiolucencies with a predilection for the posterior mandible. Unlike maxillary lesions, pain and expansion are inconsistent findings in mandibular lesions. Jaw lesions are not associated with extragnathic bone or soft tissue involvement or a hyperlipidemia. The central xanthoma of the jaws is a unique benign tumor. Histopathologically, many other jaw lesions contain variable numbers of foamy histiocytes. Therefore, a diagnosis of a central xanthoma of the jaws must be made after excluding all other such histiocyte containing lesions. This requires correlation of histopathological findings with clinical and radiographic features.

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Xanthomatous lesions of the mandible: Osseous expression of non-X histiocytosis and benign fibrous histiocytoma

Harsanyi

Larsson²

1988

Oral Surgery, Oral Medicine, Oral Pathology

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Case 44, part I

Cited by 8 publications

References 1 publication

Solitary primary intraosseous xanthoma of the mandible in a 15-year-old boy: a case report

Solitary primary intraosseous xanthoma of the mandible in a 15-year-old boy: a case report

Central Xanthoma of the Jaw Bones: A Benign Tumor

Xanthomatous lesions of the mandible: Osseous expression of non-X histiocytosis and benign fibrous histiocytoma

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