Case 40351

Cabot, Richard C.; Castleman, Benjamin; Towne, Virginia W.

doi:10.1056/nejm195409022511008

Cited by 79 publications

(25 citation statements)

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“…In 1954, Benjamin Castleman described an unusual benign disorder that was characterized by hyperplasia of lymphoid tissue [1]. A couple of years later, Castleman et al [2] published more cases with benign massive growth of lymph nodes that is commonly referred to as Castleman's disease (CD).…”

Section: Introductionmentioning

confidence: 99%

Neoadjuvant radiotherapy of primary irresectable unicentric Castleman's disease: a case report and review of the literature

et al. 2010

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BackgroundCastleman disease (CD) is a rare benign disorder characterised by hyperplasia of lymphoid tissue that may develop at a single site or throughout the body. The etiology of this disorder is unclear, although the histopathological presentation can be differentiated into a hyaline vascular variant, a plasma cell variant and a mixed variant. Clinically, it has been recorded that 3 manifestations of CD are characterized: a localized unicentric type, a generalized multicentric type and a mixed form. Surgery remains the main treatment for resectable unicentric CD, since removal of the large node is possible without further complications. No consensus has been reached concerning the most adequate treatment for irresectable unicentric CD.MethodsCase report of a 67 year old woman.ResultsThis report, describes the case of a 67-year-old woman with unicentric Castleman disease located in the right lower abdomen. The patient had symptoms of fatigue, dyspnoea and pain in the right lower abdomen. Computed tomography (CT)- examination revealed a tumour, which had grown to form a close relationship with the common iliac vessels and the sacral bone. A Laparotomy procedure revealed that the tumour was an irresectable mass. Neo-adjuvant radiotherapy (40 Gy) was administered in order to downsize the tumour. Six weeks later a new CT-scan revealed a major reduction of the tumour, which enabled a successful radical resection of the tumour to be performed. Histopathological analysis of the tumour showed the hyaline vascular type of CD.ConclusionsNeo-adjuvant radiotherapy should be considered in case of an irresectable unicentric CD.

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Section: Introductionmentioning

confidence: 99%

Neoadjuvant radiotherapy of primary irresectable unicentric Castleman's disease: a case report and review of the literature

et al. 2010

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“…Castleman's disease (CD), also known as angiofollicular lymph node hyperplasia, giant lymph node hyperplasia, lymph node hamartoma, as well as benign lymph node lymphoma, was first described by Dr. Benjamin Castleman in a patient with solitary mediastinal lymph nodes in 1954[1] and in a group of largely asymptomatic patients with benign mediastinal lymphadenopathy in 1956[13]. It is now considered part of the uncommon spectrum of lymphoproliferative disorders which have several distinct pathological and clinical variants[14].…”

Section: Discussionmentioning

confidence: 99%

“…First described in 1954, Castleman's disease (CD)[1] is a rare lymphoproliferative disorder involving lymphocyte proliferation and excessive cytokine production. The characteristic lymphoid tumors may occur singly or in a multicentric pattern, the latter being more commonly associated with signs and symptoms including fever, weight loss, anemia, anorexia, and low white blood cell count.…”

Section: Introductionmentioning

confidence: 99%

Video assisted thoracoscopic resection of a posterior mediastinal Castleman's tumor

Shetty

Brenes

Panait

et al. 2011

J Cardiothorac Surg

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Castleman's disease (CD) or angiofollicular lymph node hyperplasia is a rare spectrum of lymphoproliferative disorders. CD tumors are commonly localized in the mediastinum and are usually asymptomatic. The mainstay of treatment is surgical resection and has typically been performed using open thoracotomy. Few reports in the literature describe video assisted thoracoscopic resection of these tumors. The differential diagnosis for mediastinal masses is extensive, and CD tumors, although uncommon, should be considered. We describe a case report of a posterior mediastinal Castleman's tumor adherent to the esophagus, which was resected thoracoscopically and review the literature.

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“…Castleman disease is a nontumoral lymphoproliferative disorder initially described by Castleman and Towne in 1954 [1] usually characterized as either unicentric (UCD) or multicentric Castleman disease (MCD). UCD is an isolated lymph adenopathy without symptoms except those due to the tumoral mass while MCD is defined by the presence of diffuse lymph adenopathy and hepatosplenomegaly associated with systemic inflammatory manifestations: fever, asthenia, and weight loss.…”

Section: Introductionmentioning

confidence: 99%

Anasarca, Fever, Thrombocytopenia, Organomegaly, and Multiorgan Failure in a 24-Year-Old Pregnant Woman

Morel

Mootien²,

Guiot³

et al. 2017

Case Reports in Critical Care

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TAFRO syndrome is a distinct idiopathic multicentric Castleman disease characterized by the association of thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly. We report the first case occurring in a Caucasian pregnant woman. At 34 weeks of gestation, our patient presented with all clinical and biological symptoms compatible with a TAFRO syndrome. Tough quick cesarean section was performed as symptoms got worse with onset of multiorgan failure requiring mechanical ventilation for acute respiratory distress, continuous renal replacement, and vasopressors. Nine days after ICU admission, steroid boluses were started and allowed spectacular clinical and biological improvement. As systemic inflammatory manifestations are important, TAFRO syndrome can be mistaken with severe autoimmune diseases, systemic infections, hematological malignancies, or hemophagocytic lymphohistiocytosis.

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Case 40351

Cited by 79 publications

References 0 publications

Neoadjuvant radiotherapy of primary irresectable unicentric Castleman's disease: a case report and review of the literature

Neoadjuvant radiotherapy of primary irresectable unicentric Castleman's disease: a case report and review of the literature

Video assisted thoracoscopic resection of a posterior mediastinal Castleman's tumor

Anasarca, Fever, Thrombocytopenia, Organomegaly, and Multiorgan Failure in a 24-Year-Old Pregnant Woman

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