Case 251: Nontraumatic Drug-associated Rhabdomyolysis of Head and Neck Muscles

Abstract

History A 21-year-old man with a history of abuse of multiple drugs and mild cognitive impairment who initially underwent treatment for excited delirium developed respiratory arrest shortly after admission and was successfully resuscitated. Unenhanced computed tomography (CT) of the head and neck and contrast material-enhanced CT of the chest, abdomen, pelvis, and complete spine were performed shortly after the initial treatment. Head and neck magnetic resonance (MR) imaging was performed 24 hours after admission. No other abnormalities were noted. There were no fractures, and there was no vascular injury in the head and neck region. The patient had no external neck injuries, congestion, or petechiae suggesting neck compression. He had no history of chronic or recurrent pain or skin rash. Urine testing was positive for cocaine, cannabis, and methamphetamine. Serum creatine kinase level was initially high (31 117 U/L [520 μkat/L]; normal, 1000 U/L [16.7 μkat/L]). Corrected calcium level was 2.22 mmol/L, and ionized calcium level was 1.09 mmol/L (lower end of the normal range). There was no acute renal failure at the initial phase, but serum creatinine levels reached 180 µmol/L 24 hours after admission, and creatine kinase peaked at 61 000 U/L [1019 μkat/L]. Urine was initially red, but the patient was not tested for myoglobinuria.

Evaluation of KIM-1 as an early biomarker of snakebite-induced AKI in mice

“…Bothrops venom causes decrease in the blood pressure (Sciani and Pimenta, 2017) and functional injuries such as vasospasm might be existed on the kidney. Also, BinsV might induce muscle injures as the other toxins (White, 2000) and this could increase serum creatinine, which are unspecific marker (Debelmas et al, 2018). They might be the reasons of the discrepancy of serum creatinine and Fig.…”

Current View on the Use of Extracorporeal Detoxification Methods for the Treatment of Rhabdomyolysis (Review)

“…По литературным данным в 60% случаев рабдомиолиз развивается вследствие различных экзогенных отравлений (алкоголь и наркотические средства) [30,31]. Синдром длительного сдавления (краш-синдром) также является одной из частых причин возникновения данного синдрома [32,33].…”

Alterações Orofaciais Relacionadas Ao Uso De Crack E Cocaína – Uma Revisão Sistemática

“…2 artigos não especificaram o sexo do paciente: (YANAGISAWA et al,1996e RAPILA & KASHAN., 1997. 10 artigos não especificaram a quantidade de substância ou frequência usada: (MALDJIAN.,2020;GATT et al, 2019, CHHABRA & ABRAHAM, 2013, DEBELMAS et al, 2018, BARREIRA et al, 2018, YANAGISAWA & LATORRE, 1996, CASTELLO et al, 2014, MOLTENI et al, 2016, BAINS & ARDEHALI, 2005, MORA et al, 2002. A via de uso da substância foi especificada em 9 artigos: (MORA et al, inicialmente se mostrou evasivo quanto á admitir o uso da substância (VILELA et al, 2002), mas a colaboração com informações a respeito da adicção foram essenciais para um melhor entendimento e estabelecimento de relações causa-consequência nos relatos.…”

“…,BAINS & ARDEHALI, 2005, MOLTENI et al, 2016, SIEMENRIKA et al, 2017, BRADFORD et al, 2010, KANNAN et al, 2011, CHHABRA & ABRAHAM, 2013, LYPKA 2007, WELLING 2008. 5 artigos especificaram que o paciente usava mais de uma substância:(DEBELMAS et al, 2018, PADILLA-ROSAS et al, 2006, BUNACHAN et al, 2010, VILLA, 1999 e CHHABRA & ABRAHAM 2013. A quantidade de substância especificada em gramas foi relatada em 8 artigos:(BLANCO et al, 2017, PADILLA-ROSAS et al, 2006, CAPUTO et al, 2007, O'CONNOR t al., 2005, SMITH et al, 2002, FINES et al, 1997, GERTNER & HAMLAR 2001, MARI et al, 2002.…”