Case 24-1976

Carey, Robert W.; Galdabini, James J.

doi:10.1056/nejm197606102942408

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…One patient responded to thoracentesis and treatment with hydroxyurea without recurrence (9), and another patient responded to systemic chemotherapy with idarubicin and Ara-C (10). In 5 patients, in which pleural blast antedated hematological transformation, intrapleural infusion of chemotherapeutic agents (methotrexate, cytosine arabionside, prednisone) and systemic chemotherapy were ineffective, and all 5 patients died within 2 months (3, 4, 7, 8). In the remaining patient, the type of treatment was not reported (2).…”

Section: Discussionmentioning

confidence: 99%

A Case of Leukemic Pleural Infiltration in Atypical Chronic Myeloid Leukemia

et al. 2006

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Pleural effusion in chronic myeloid leukemia (CML) is poorly understood and rarely reported in the literature. When the pleural effusion is caused by leukemic pleural infiltration, the differential white blood cell count of the effusion is identical to that of the peripheral blood, and the fluid cytology reveals leukemic blasts. We report here a case of bilateral pleural involvement of atypical CML in an 83-yr old male diagnosed with pancreatic cancer with abdominal wall metastasis and incidental peripheral leukocytosis. Based on bone marrow examination, chromosome analysis and polymerase chain reaction he was diagnosed with Philadelphia chromosome negative, BCR/ABL gene rearrangement negative CML. Following 3 months of treatment with gemcitabine for pancreatic cancer, he developed bilateral pleural effusions. All stages of granulocytes and a few blasts were present in both the pleural fluid and a peripheral blood smear. After treatment with hydroxyurea and pleurodesis, the pleural effusion resolved.

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Section: Discussionmentioning

confidence: 99%

A Case of Leukemic Pleural Infiltration in Atypical Chronic Myeloid Leukemia

et al. 2006

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Pleural effusions in acute and chronic leukemia and myelodysplastic syndrome

Faiz

Sahay

Jiménez

2014

Current Opinion in Pulmonary Medicine

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Pleural effusions may occur with acute and chronic leukemia and MDS. Infection remains the most common cause. Malignant pleural effusions tend to occur in advanced disease in chronic leukemia, but they can be seen at any time with acute leukemia and MDS. With standard precautions, pleural procedures may be performed safely in this population. In cases of unclear cause, pleural and bone marrow biopsy should be considered.

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