“…The symptom of isolated genital edema in a boy has a differential diagnosis (Table 1) that normally would not include metastatic Crohn disease. In this case, other con- No response, less gastrointestinal complaint, but no improvement in lymphoedema (which was already present for 3 y) very similar to this have been described (2-5,7), but all patients had bowel symptoms (and gastrointestinal inflammation) either before (2), during (3,7), or years after the onset of genital symptoms (4,5). In an excellent review and additional case reports, Ploysangam et al (7) described 80 cases of cutaneous Crohn disease, 14 of which were in children.…”