CASE 2. Meningeal Metastases From Ovarian Carcinoma

Mukhopadhyay, Surabhi; Mukhopadhyay, Sanjay; El‐Zammar, Ola; Khurana, Kamal K.; Graziano, Stephen L.

doi:10.1200/jco.2005.01.2427

Cited by 5 publications

(2 citation statements)

References 7 publications

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“…In conclusion, leptomeningeal involvement is a very rare event in the natural history of ovarian carcinoma. As observed in our case, it is usually of late occurrence and its prognosis is poor (12,15) . A summary of this discussion is presented in Table 1.…”

Section: Discussionsupporting

confidence: 62%

Ovarian cancer associated with carcinomatous meningitis: a case report and review of the literature

Decelle¹,

D’Hondt²,

Andre³

et al. 2007

Int J Gynecol Cancer

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We report the case of a 62-year-old patient who developed a carcinomatous meningitis while on second-line chemotherapy for ovarian cancer. Cytologic analyses confirmed that carcinomatous cells of ovarian origin were present in cerebrospinal fluid. Carcinomatous meningitis is a very rare event in the natural history of ovarian carcinoma. We discuss the specificity of our case in the light of the literature. In addition, we present some relevant radiologic and pathologic documents illustrating this rare entity.

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Section: Discussionsupporting

confidence: 62%

Ovarian cancer associated with carcinomatous meningitis: a case report and review of the literature

Decelle¹,

D’Hondt²,

Andre³

et al. 2007

Int J Gynecol Cancer

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“…Ovarian cancer metastasis often involves the peritoneum and pleura, and liver, lung, and distant lymph node metastasis are also common. The incidence of brain metastasis from ovarian cancer ranges from about 1 to 3% (4). The optimal treatment for brain metastases from ovarian cancer is currently ill-defined because of the rarity and small number of these patients.…”

Section: Introductionmentioning

confidence: 99%

Successful Treatment of a Patient With Brain Metastasis From Ovarian Cancer With BRCA Wild Type Using Niraparib: A Case Report and Review of the Literature

Zhang

Sakandar

et al. 2022

Front. Oncol.

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BackgroundBrain metastases from ovarian cancer are extremely rare and have a very poor prognosis. A multimodal approach (surgery combined with radiotherapy and chemotherapy) yields the best results in reducing neurological symptoms and prolonging survival. Unfortunately, not every patient receives a complete multimodal treatment due to their individual factors. Poly(ADP-ribose) polymerase (PARP) inhibitors have emerged as a maintenance treatment option for recurrent ovarian cancer. Using PARPi may prolong the overall survival in patients with brain metastases and recurrent ovarian cancer.Case PresentationWe report a case of a female patient with advanced ovarian cancer without any germline or somatic BRCA mutation. After 21 months, after reduction surgery and adjuvant chemotherapy, she was diagnosed with brain metastasis. Due to her physical fitness and economic situation, she did not receive any radiotherapy or chemotherapy but only received surgical debulking of the brain metastasis and niraparib maintenance treatment. Up to now, she has achieved a good treatment response, and the PFS is 29 months.ConclusionBased on the response of our patient, PARP inhibitors as a single agent can probably be considered in patients with brain metastasis from ovarian cancer without BRCA mutation who cannot tolerate radiotherapy and chemotherapy.

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Meningeal Carcinomatosis and Uterine Carcinoma: Three Different Clinical Settings and Review of the Literature

Asensio¹,

Luís²,

Costa

et al. 2009

Int J Gynecol Cancer

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CASE 2. Meningeal Metastases From Ovarian Carcinoma

Cited by 5 publications

References 7 publications

Ovarian cancer associated with carcinomatous meningitis: a case report and review of the literature

Ovarian cancer associated with carcinomatous meningitis: a case report and review of the literature

Successful Treatment of a Patient With Brain Metastasis From Ovarian Cancer With BRCA Wild Type Using Niraparib: A Case Report and Review of the Literature

Meningeal Carcinomatosis and Uterine Carcinoma: Three Different Clinical Settings and Review of the Literature

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