Myxoma of the right atrium is a rare heart tumor. Atrial myxomas are associated with a triad of complications, including obstruction, emboli, and constitutional symptoms (such as fever, weight loss). An interdisciplinary approach is very important to optimize the outcome in patients with atrial myxomas. When myxoma present, it can rarely cause blood flow obstruction in the right cardiac chamber. 75% to 80% are located on the left side of the interatrial septum. Right-sided cardiac myxomas present surgeons a lot of technical difficult. We report a case of right atrial myxoma. A 75-year-old female with a large right atrial myxoma underwent surgical treatment in our Center. Due to the high risk of embolic complications associated with conventional connection of a cardiopulmonary bypass machine, we decided to preform beating-heart surgery with clamping of major vessels (aorta, pulmonary artery, and venae cavae). This technique is a method of avoiding embolization. The early postoperative period was uneventful. Two days postoperatively, the patient was transferred from the intensive care unit to hospital ward. Nine days postoperatively, she was discharged in satisfactory condition to continue her follow-up at a local outpatient department. The patient was followed up during the next 3 years and had no signs of relapse.