Case 12-1972

Cabot, Richard C.; Scully, Robert E.; McNeely, Betty U.; Sanders, Charles A.; Castleman, Benjamin

doi:10.1056/nejm197203232861209

Cited by 11 publications

(7 citation statements)

References 6 publications

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“…Nontraumatic subdural fluid collection associated with dural metastasis is quite rare. To our knowledge, only five cases [ 6 , 13 , 20 , 24 , 29 ] have so far been described (Table 1 ), and in the previous reports, no mucous material was investigated by histopathological examinations.…”

Section: Discussionmentioning

confidence: 99%

“…The primary sites of tumors that cause subdural fluid collection following dural metastasis of malignant tumors are widely divergent, and involve Hodgkin’s disease [ 20 ], pancreatic cancer [ 6 ], prostate cancer [ 29 ], and rectal cancer [ 12 ] (Table 1 ). On the other hand, primary sites of tumors giving rise to subdural hematoma associated with dural metastasis are gastric, prostate, pancreatic, breast, lung, and uterine cancers [ 10 , 11 , 13 , 17 – 19 , 22 , 23 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, as regards patients with subdural hematoma caused by dural metastasis of malignant tumors, only about 40 cases have been reported as far as we are aware [ 1 – 5 , 7 – 11 , 13 – 19 , 21 , 23 , 25 – 28 , 30 – 32 ]. However, there are only five reported cases of subdural fluid collection caused by dural metastasis of malignant tumors [ 6 , 12 , 20 , 24 , 29 ]. Furthermore, when subdural fluid collection caused by dural metastasis of malignant tumors occurred, it was due to mucous effusion produced by the tumor cells in three of these five patients [ 6 , 12 , 20 ], although none of those three cases underwent histopathological examinations.…”

Section: Introductionmentioning

confidence: 99%

“…However, there are only five reported cases of subdural fluid collection caused by dural metastasis of malignant tumors [ 6 , 12 , 20 , 24 , 29 ]. Furthermore, when subdural fluid collection caused by dural metastasis of malignant tumors occurred, it was due to mucous effusion produced by the tumor cells in three of these five patients [ 6 , 12 , 20 ], although none of those three cases underwent histopathological examinations. In our case report, we demonstrate that the pathogenetic mechanism of the subdural fluid collection associated with dural metastasis differed from that of subdural hematomas associated with dural metastasis reported previously.…”

Section: Introductionmentioning

confidence: 99%

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Acute aggravation of subdural fluid collection associated with dural metastasis of malignant neoplasms: case report and review of the literature

et al. 2013

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A 63-year-old woman was admitted to our hospital with serious headache and vomiting. Five months before admission, she had undergone surgery for a primary advanced gastric cancer. Neuroradiological examinations revealed subdural fluid collection. We twice performed evacuation of the subdural fluid collection. However, aggravation of her state of consciousness progressed and she passed away. Histological examinations demonstrated that the dural veins were infiltrated by numerous tumor cells that produced mucus; however, ruptured vessels were not found. Furthermore, the subdural fluid collection increased shortly after the initial operation. We infer that the cause of the collection, which was associated with the dural metastasis of malignant tumors, was not only mucin secretion by tumor cells but also a rapid increase in perfusion pressure in the vessels of the dura mater, resulting in extravasation of plasma components into the subdural space. Our case demonstrates that the pathogenetic mechanism that is specific for subdural fluid collection caused by dural metastasis of malignant tumors differs from the mechanism of production of subdural hematoma associated with dural metastasis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Acute aggravation of subdural fluid collection associated with dural metastasis of malignant neoplasms: case report and review of the literature

et al. 2013

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“…A case report published in 1972 at New England Journal of Medicine [20] and a case report by Olson et al [21] reported bilateral subdural hematomas in patients with a primary PC. It is necessary to emphasize that our patient lacks the history of a significant head trauma, and the PC brain metastases might contribute to the development of subdural hematomas in our patient as well.…”

Section: Discussionmentioning

confidence: 99%

Epidural Brain Metastases in a Patient with Early Onset Pancreatic Cancer: A Case Report and Literature Review

Mirrakhimov

Khan

2012

Case Reports in Oncological Medicine

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We present a case of early onset pancreatic cancer related extra-axial brain metastases. A 46-year-old Caucasian non-Jewish nonobese male with a history of PC diagnosed 3 months ago with metastases to the liver, omentum, malignant ascites, and a history of a pulmonary embolism was admitted to the hospital because of a new onset headache, nausea, and vomiting which started 2 days prior to the encounter. Brain MRI was ordered, which showed acute bihemispheric subdural hematomas and left hemispheric extra-axial heterogeneously enhancing lesions consisting with metastatic disease. The patient was started on ondansentron, metoclopramide, and dexamethasone. The cranial irradiation was started, and the patient's headache and nausea significantly improved. There are only 9 published reports of extra-axial brain metastases related to the pancreatic cancer, whereas our paper is the first such case reported on a patient with epidural metastases and early onset pancreatic cancer.

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