Cascade Self-Generation of Carbon Monoxide Triggered by Photoinduced Holes for Efficient Hypoxic Tumors Therapy
Chuanye Tang,
Pinghua Ling,
Xianping Gao
et al.
Abstract:It
still remains challenging to design multifunctional
therapeutic
reagents for effective cancer therapy under a unique tumor microenvironment
including insufficient endogenous H2O2 and O2,
low pH, and a high concentration of glutathione (GSH). In this work,
a CO-based phototherapeutic system triggered by photogenerated holes,
which consisted of ionic liquid (IL), the CO prodrug Mn2(CO)10, and iridium(III) porphyrin (IrPor) modified carbonized
ZIF-8-doped graphitic carbon nitride nanocomposite (IL/ZCN@Ir(CO)),… Show more
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