Cascade Reactions in Total Synthesis

Nicolaou, K. C.; Edmonds, David J.; Bulger, Paul G.

doi:10.1002/anie.200601872

Cited by 1,988 publications

(550 citation statements)

References 808 publications

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“…Although widely used in organic synthesis and catalytic process [86], recently, the cascade reaction is employed as well in polymer mechanochemistry. As a specific form of covalent mechanoluminescence, cascade mechanoluminescence involves multi-steps conversion of mechanical energy to luminescence.…”

Section: Cascade Mechanoluminescen Cementioning

confidence: 99%

Recent advances in mechanoluminescent polymers

Yuan

Chen

2016

Sci. China Mater.

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In recent years, mechanoluminescence from polymers is emerging as a new cutting-edge area of polymer mechanochemistry research. It refers to the release of energy from polymers in the form of light when they are under various mechanical stimuli. To spur more researchers to join in such interesting and new burgeoning area, and promote its development to practical applications, in this review, we try to briefly summarize the recent advances in mechanoluminescent polymers with the aspects of non-covalent, covalent, and cascade reactions systems. We pay much attention on the applications of such polymer systems in molecular level failure and stress sensors, and give a perspective of their potential applications in novel energy conversion materials and devices, as well as self-healing materials.

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Section: Cascade Mechanoluminescen Cementioning

confidence: 99%

Recent advances in mechanoluminescent polymers

Yuan

Chen

2016

Sci. China Mater.

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“…The most useful MCRs have additional advantages of selectivity, synthetic convergence, atom-economy and green credentials. [4][5][6][7][8][9] Further, MCRs are perfectly amenable for automation to generate combinatorial libraries of biologically relevant heterocyclic scaffolds and hence play a pivotal role in lead identification and drug development programmes.…”

Section: Introductionmentioning

confidence: 99%

A facile regio- and stereoselective synthesis of trans-ethyl 5-aroyl-4-aryl-2-[(arylsulfonyl)methyl]-4,5-dihydrofuran-3-carboxylates

Harikrishnan¹,

Rajesh²,

Almansour³

et al. 2013

Arkivoc

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A library of novel trans-ethyl 5-aroyl-4-aryl-2-[(arylsulfonyl)methyl]-4,5-dihydrofuran-3-carboxylates were synthesized regio-and stereoselectively in good yields by a three-component domino reaction of ethyl-3-oxo-4-(arylsulfonyl)butanoates, aromatic aldehydes and Nphenacylpyridinium bromide in presence of triethylamine in acetonitrile under heating. This transformation generates C-O, C-C and C=C bonds and presumably proceeds via an α,β-unsaturated ketosulfonyl ester generation/Michael addition/intramolecular cyclisation domino sequence.

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“…One pot tandem reactions, such as the RauhutCurrier reaction, are important for the efficient construction of complex chemical structures and therefore are an active research area in the synthetic community. [23][24][25][26][27][28][29][30][31] The intramolecular Rauhut-Currier reaction 32 has experienced a resurgence based on groundbreaking studies by Krische, 33 Murphy, 34,35 and Roush. 36 Under the influence of catalytic phosphine, conjugated systems can be merged to form a new ring while retaining one conjugated system for subsequent functionalization.…”

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confidence: 99%