Cascade Cyclization/Amination of para‐Quinone Methides with β‐Ketodinitriles: Synthesis of Polysubstituted Furans
Liyong Fan,
Longzhi Zhu,
Wenli Shang
et al.
Abstract:A protocol for the synthesis of trisubstituted furans via phosphoric acid‐catalyzed regioselective cascade cyclization/amination of para‐quinone methides (p‐QMs) with β‐ketodinitriles has been disclosed for the first time. Various kinds of p‐QMs and β‐ketodinitriles can effectively produce the desired polysubstituted furan derivatives in 64‐95% yields, demonstrating high atomic economy and their application in the construction of polysubstituted furan heterocycles. Preliminary biological activity assay suggest… Show more
A palladium-catalyzed cyclization/etherification cascade of N-propargyl arylamines containing a 1,3-dicarbonyl side chain is described for the synthesis of polysubstituted furans bearing indoline skeletons under mild conditions.
A palladium-catalyzed cyclization/etherification cascade of N-propargyl arylamines containing a 1,3-dicarbonyl side chain is described for the synthesis of polysubstituted furans bearing indoline skeletons under mild conditions.
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