Cascade catalytic platform modified intraocular lens for high-efficient posterior capsule opacification prevention

Augmented cellular uptake and homologous targeting of exosome-based drug loaded IOL for posterior capsular opacification prevention and biosafety improvement

“…As mentioned above, the severity of PCO can be graded according to the development of PCO: central posterior capsular opacification (CPCO, the 3 mm diameter pouch in the optical center), peripheral posterior capsular opacification (PPCO, the 6 mm diameter pouch in the optical region except the central part), Soemmering's ring (SR, the peripheral part of the capsule) and no PCO occurs [ 8 , [13] , [14] , [15] ]. The severity of PCO in each level was assessed on a scale of 0–3 points.…”

“…At present, in addition to the optimization of IOL shape and development of novel IOL materials, IOL surface modification, which is easy to prepare and does not require extra intraocular surgery also contributes to PCO prevention [ 6 , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] ]. In previous studies, researchers mainly focused on hydrophilic coating on the IOL surface to prevent the adhesion of LECs [ [19] , [20] , [21] , [22] ].…”

A zwitterionic silver nanoparticle-incorporating injectable hydrogel with a durable and efficient antibacterial effect for accelerated wound healing

“…The cytotoxicity of the PSBDA@AgNPs–GelMA–PVA hydrogel was evaluated on L929 cells and HaCaT cells according to the previously published method. 58 L929 cells or HaCaT cells were cultivated in the DMEM containing 10% FBS and 1% penicillin–streptomycin (5% CO 2 , 37 °C). The sterilized hydrogel (1 × 1 × 0.1 cm) was placed in a 24 well plate.…”

Recent Advances of Intraocular Lens Materials and Surface Modification in Cataract Surgery

“…Horseradish peroxidase (HRP) and glucose oxidase (GOD) were used to catalyse the production of reactive oxygen species, resulting in cell apoptosis. Huang et al (2022) immobilized GOD and HRP on IOL surface via mesoporous silica nanoparticles (MSNs) and obtained positive results.…”