Abstract:Radio-immunotherapy exploits the immunostimulatory features of ionizing radiation (IR) to enhance antitumor effects and offers emerging opportunities for treating invasive tumor indications such as melanoma. However, insufficient dose deposition and immunosuppressive microenvironment (TME) of solid tumors limit its efficacy. To address these challenges, a cascade-amplification strategy based on multifunctional fusogenic liposomes (Lip@AUR-ACP-aptPD-L1) was reported. The liposomes were loaded with gold-containi… Show more
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