Caryophyllene sesquiterpenoids with various ring systems from the fungus Pestalotiopsis chamaeropis

Kang, Xin; Yang, Wanqi; Zheng, Yuyi; Zheng, Meijia; Xiao, Yang; Wang, Jianping; Zhu, Hucheng; Li, Qin; Chen, Chunmei; Zhang, Yonghui

doi:10.1016/j.phytochem.2022.113569

Search citation statements

Order By: Relevance

Paper Sections

Select...

Results1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pestalotiopsins A-T have been reported from different fungi so far ( Pulici et al, 1996 , 1997 ; Baker et al, 2008 ; Xiao et al, 2017 ; Putra et al, 2019 ; Tayone et al, 2020 ; Kang et al, 2023 ); however, they seldom showed cytotoxicity. In our study, all compounds were tested for cytotoxicity against the mouse lymphoma cell line L5178Y, but only compound 6 exhibited potent cytotoxicity with an IC 50 value of 2.4 μM compared to the positive control of 4.3 μM.…”

Section: Resultsmentioning

confidence: 99%

Caryophyllene-type sesquiterpenes from the endophytic fungus Pestalotiopsis lespedezae through an OSMAC approach

Yu,

Müller,

Frank

et al. 2024

Front. Microbiol.

View full text Add to dashboard Cite

Two new caryophyllene-type sesquiterpenes pestalotiopsins U and V (1 and 2) and three known compounds pestalotiopsin B (7), pestaloporinate B (8), and pestalotiopsin C (9) were isolated by the cultivation of the endophytic fungus Pestalotiopsis lespedezae on solid rice medium, while four additional new caryophyllene pestalotiopsins W–Z (3–6) were obtained when 3.5% NaI was added to the fungal culture medium. The structures of the new compounds were determined by HRESIMS and 1D/2D nuclear magnetic resonance data. Compounds 1–9 were tested for cytotoxicity against the mouse lymphoma cell line L5178Y, but only 6 displayed significant activity with an IC50 value of 2.4 μM.

show abstract