Caryocar brasiliense fruit intake ameliorates hepatic fat deposition and improves intestinal structure of rats

Moreno, Lauane Gomes; Oliveira, Lidiane Guedes; Melo, Dirceu de Sousa; Pereira, Liliane Vanessa Costa; Costa, Karine Beatriz; Miranda, João Luiz de; Vieira, Etel Rocha; Magalhes, Flvio Castro; Peixoto, Marco Fabrício Dias; Esteves, Elizabethe Adriana

doi:10.5897/jmpr2016.6222

Cited by 7 publications

(4 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Oleic acid was the second dominant composition in the oil, with a value of 31.20%, higher than the composition of saturated fatty acids, which was 22.50%, being the largest portion of palmitic acid. The content of fatty acids verified in this study was similar to the work of Ferreira et al; 8 however, it is different from the composition reported in the literature, 21,22 where oleic and palmitic acids were the dominant contents in pequi oil. The difference between the oil composition found by the authors and others found in the literature can be explained by some factors such as soil, climate, harvest time, fruit ripening, and geographic location.…”

Section: ■ Results and Discussionsupporting

confidence: 76%

Pequi Oil Esters as an Alternative to Environmentally Friendly Lubricant for Industrial Purposes

Ferreira

Arruda

Rodrigues³

et al. 2022

ACS Sustainable Chem. Eng.

View full text Add to dashboard Cite

This study reports the synthesis of bio-based lubricants using pequi oil (PO) as a raw material, along with its chemical, thermal, and rheological characterization, as well as its cytotoxic behavior and the kinetic study of the reaction involved in the production of biolubricants. Free fatty acid pequi oil (PFFA) was esterified using 2-ethyl-1-hexanol (P2EHE), pentaerythritol (PPEE), and p-TSA as catalysts. The 1 H NMR spectra confirmed the replacement of hydroxyl groups of both alcohols by PFFA. PPEE showed better thermal stability (T onset 274.50 °C). Besides, at 50% of thermal weight loss, the PPEE showed a higher decomposition temperature (437.9 °C) than PO (366.6 °C). The melting points determined by DSC indicate that P2EHE exhibits better performance at low temperatures (p.p. −22.86 °C) than PPEE (p.p. −33.28 and 8.02 °C) due to the presence of some crystals of saturated fatty acids in the pentaerythritol ester. The esters showed Newtonian behavior in a wide range of shears; however, they showed pseudoplastic behavior at temperatures above 60 °C. The viscous nature of bio-based lubricants was confirmed (G″ > G′) even with increasing temperature. The kinetic study provided the value of the activation energy to P2EHE and PPEE, similar to that reported in the literature for other types of biolubricants. The toxicity analysis of bio-based lubricants on adult zebrafish showed no lethality after 96 h. These results suggest that pequi oil is a potential raw material to produce lubricants that are less harmful to the environment.

show abstract

Section: ■ Results and Discussionsupporting

confidence: 76%

Pequi Oil Esters as an Alternative to Environmentally Friendly Lubricant for Industrial Purposes

Ferreira

Arruda

Rodrigues³

et al. 2022

ACS Sustainable Chem. Eng.

View full text Add to dashboard Cite

show abstract

“…Conversely, although hepatic TG reduction was a timely result, a previous study from our lab also showed a significant reduction of those parameters in rats fed pequi pulp providing a 50% increase of dietary oil [38]. In addition, despite this result could not be related directly to cardiac function, there is a great body of evidence connecting hepatic lipid accumulation to cardiovascular risk, independently of coexisting cardiometabolic risk factors [46].…”

Section: Discussionmentioning

confidence: 89%

“…Pequi oil, accordingly to data available elsewhere [6, 38, 39], had oleic acid as its major fatty acid, being higher than olive oil, the main dietary source of it [40]. Otherwise, the second major fatty acid was palmitic, an important dietary SFA [41].…”

Section: Discussionmentioning

confidence: 99%

“…However, we chose to increase dietary lipids by 50% using pequi oil because we tried to associate some basic results gotten from pre-tests and in this way, the diet did not turned into a high fat [9]. Besides, our research group and others showed, previously, improvements in systemic cardiovascular risk factors in rats and humans fed pequi pulp or pequi oil pills providing 600 mg/d of pequi oil [23–25, 38, 39]. In this way.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Caryocar brasiliense oil improves cardiac function by increasing Serca2a/PLB ratio despite no significant changes in cardiovascular risk factors in rats

Oliveira¹,

Moreno

Melo

et al. 2017

Lipids Health Dis

View full text Add to dashboard Cite

Background Caryocar brasiliense (pequi) oil is high in monounsaturated fat acids (MUFA), especially oleic, and in carotenoids, which have been associated with protection against cardiovascular disease. However, this food is poorly studied in this context, especially in the cardiac function. Therefore, we investigated the effects of a long-term intake of pequi oil in systemic cardiovascular risk factors and in the ex vivo cardiac function of rats.MethodsPreviously, we determined fatty acids and carotenoids in pequi oil. Next, male rats were divided in C – control group feed a standard diet, and PO – pequi oil group fed the same diet added pequi oil (+2.25 g.100 g−1). After 15 weeks, plasma lipids, glucose, insulin, blood pressure, heart rate, hepatic lipids were accessed and visceral fat pads were harvested. Hearts were used for the ex vivo cardiac function, histologic assays, SERCA2a and phospholanban (PLB) determinations.ResultsIn agreement with scientific data, pequi oil had expressive amounts MUFA, especially oleic acid, and carotenoids. Hepatic triglycerides (TG) were reduced by pequi oil intake (p < 0.05). All others cardiovascular risk factors were not changed. The intrinsic heart rate was lower in PO group (p < 0.05). SERCA2a content was higher in this group (p < 0.05), without affecting PLB. Also, SERCA2a/PLB ratio increased in PO group (p < 0.05).Conclusion Pequi oil intake improved cardiac function ex vivo, despite no significant changes in systemic cardiovascular risk factors. The higher lipid offer in pequi oil diet, its composition in oleic acid and carotenoids could be related to those effects.

show abstract

Pequi Oil, a MUFA/Carotenoid‐Rich Oil, Exhibited Protective Effects against DSS‐Induced Ulcerative Colitis in Mice

Moreno

Evangelista‐Silva

Santos

et al. 2021

Euro J Lipid Sci & Tech

View full text Add to dashboard Cite

Inflammatory bowel diseases (IBD) affect the gastrointestinal tract, and the imbalance of intestinal immune homeostasis can trigger them. Pequi oil (PO), a monounsaturated (MUFA) and carotenoid-rich food with nutraceutical potential, could help reshape the intestinal immune response, ameliorating IBD outcomes. This study investigates the effects of a 28 days intake of PO on elements of the intestinal immune response of mice with DSS-induced ulcerative colitis (disease activity index, colonic damage, inflammatory cells and markers). PO reduces body weight, colonic crypt and goblet cell losses and ameliorates diarrhea. In the colon, it increases T cells and secretory-IgA and decreases CD8+T cells. In lymphoid organs, it reduces CD8+T cells. Moreover, it also reduces the IL-17 and CRP in plasma. PO oil promotes a less cytotoxic response that may protect mice from immunological injuries caused by an IBD in the intestinal mucosa, improving the disease prognosis. Practical applications: This study demonstrates that the intake of pequi oil contributes to the regulation of immune response and improves clinical and histological signs of DSS-induced ulcerative colitis in mice. Its effects in cytotoxic cell reduction and other inflammatory markers and stimulation of regulatory cells, and preservation of mucus-producing cells, provide news insights about the importance of the regular intake of this food to better prognosis of ulcerative colitis acute episodes. In addition, these findings encourage further studies with foods with a protective potential for the intestinal mucosa.

show abstract

Caryocar brasiliense fruit intake ameliorates hepatic fat deposition and improves intestinal structure of rats

Cited by 7 publications

References 36 publications

Pequi Oil Esters as an Alternative to Environmentally Friendly Lubricant for Industrial Purposes

Pequi Oil Esters as an Alternative to Environmentally Friendly Lubricant for Industrial Purposes

Caryocar brasiliense oil improves cardiac function by increasing Serca2a/PLB ratio despite no significant changes in cardiovascular risk factors in rats

Pequi Oil, a MUFA/Carotenoid‐Rich Oil, Exhibited Protective Effects against DSS‐Induced Ulcerative Colitis in Mice

Contact Info

Product

Resources

About