Carvone Contact Allergy in Southern Sweden: A 21-year Retrospective Study

Kroona, Liv; Isaksson, Marléne; Ahlgren, Camilla; Dahlin, Jakob; Bruze, M.; Warfvinge, Gunnar

doi:10.2340/00015555-3009

Cited by 21 publications

(53 citation statements)

References 22 publications

(26 reference statements)

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“…Carvone, a mint flavour in spearmint oil and an oxidation product of d ‐limonene, is considered a mild sensitizer. Sensitization may be linked to oral or perioral signs, although studies are sparse 22. While we cannot draw any reliable conclusion, as these allergens were tested in only one individual patch test centre, further studies are suggested to assess their importance.…”

Section: Discussionmentioning

confidence: 86%

“…Sensitization may be linked to oral or perioral signs, although studies are sparse. 22 While we cannot draw any reliable conclusion, as these allergens were tested in only one individual patch test centre, further studies are suggested to assess their importance. This study collected data retrospectively over a 2-year period, which the authors recognize is a limitation.…”

Section: Discussionmentioning

confidence: 89%

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What is in? What is out? Updating the British Society for Cutaneous Allergy facial series*

et al. 2020

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Background Allergic contact dermatitis (ACD) to cosmetics is widely reported. To ensure we are accurately diagnosing ACD, patch test series should be continually reviewed to identify relevant and emerging allergens and highlight those that are outdated. The current British Society for Cutaneous Allergy (BSCA) facial series recommends 26 allergens and was last modified in 2012. Objectives To review and update the BSCA facial series. Methods We retrospectively reviewed the results from 12 UK and Ireland patch test centres' facial series from January 2016 to December 2017. We recorded the number of allergens tested in each centre and the detection rate for each allergen. Using a 0Á3% positive rate as the inclusion threshold, we established which allergens in the BSCA facial series had positive patch test rates < 0Á3% and > 0Á3%. Allergens not in the BSCA facial series that had a positive patch test rate > 0Á3% were identified. Results Overall, 4224 patients were patch tested to the facial series. The number of allergens included in individual centres' facial series ranged from 24 to 66, with a total of 103 allergens tested across all centres. Twelve of the 26 allergens in the BSCA facial series had a positive patch test rate < 0Á3% and 14 had a rate > 0Á3%. Twenty-five allergens not recommended in the BSCA facial series had a positive patch test rate > 0Á3%. Conclusions This audit has highlighted the significant variation in practice that exists among patch test centres, despite a recommended facial series. The BSCA facial series has been updated and now contains 24 allergens. Fifteen allergens remain, 11 allergens have been dropped and nine new allergens have been added. What is already known about this topic? • Facial dermatitis is one of the dominant presenting complaints of allergic contact dermatitis to cosmetics.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 89%

What is in? What is out? Updating the British Society for Cutaneous Allergy facial series*

et al. 2020

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“…Carvon ( L -Carvon), ein Minzaroma in Spearmint-Öl, gilt als schwacher Hautsensibilisator, wobei Allergien mit oralen/perioralen Anzeichen und oralem Lichen planus in Verbindung gebracht werden. In einer Klinik in Malmö hatten 147 von 4.221 zugewiesenen Patienten einen positiven Epikutantest auf Carvon; bei 73 % lagen orale Krankheitszeichen vor und bei 57 % oraler Lichen [87]. Bei einer spanischen Patientin wurde eine Sensibilisierung auf das in ihrer Zahnprothesen-Haftcreme enthaltene Cinnamal festgestellt [88].…”

Section: Ergebnisseunclassified

Kontaktallergien – Neu aufkommende Allergene und Auswirkungen für das Gesundheitswesen

Uter¹,

Werfel

Lepoittevin

et al. 2021

Kompass Dermatol

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Kontaktallergie (Sensibilisierung) und daraus resultierende allergische Kontaktdermatitis (ACD) sind von erheblicher Tragweite aus Sicht des Gesundheitswesens. Für die vorliegende Übersichtsarbeit hierzu wurden alle passenden Artikel aus dem Zeitraum 2018–2019 per systematischer Suche in Medline und Web of Science<sup>TM</sup> ermittelt; außerdem wurden alle verfügbaren Ausgaben der Fachzeitschriften „Contact Dermatitis“ und „Dermatitis“ manuell durchsucht und so eine frühere, ähnliche Übersichtsarbeit fortgeschrieben und neu fokussiert. Neue Allergene ebenso wie bekannte Allergene, die in neuem Expositionskontext gefunden wurden oder deren Bedeutung in sonstiger Hinsicht neu bewertet wurde, werden in Abschnitten nach Substanzklasse gegliedert beschrieben (z. B. Metalle, Konservierungsmittel, Duftstoffe). Als gemeinsames Ergebnis zahlreicher Untersuchungen fällt sowohl ein Mangel an Informationen über die Produktzusammensetzung auf, z. B. in Bezug auf ein neu beschriebenes Allergen in Leinenturnschuhen (Dimethylthiocarbamylbenzothiazolsulfid), als auch vor allem die mangelnde Kooperativität von Herstellern von Blutzuckermessgeräten bzw. Insulinpumpen. Zu den letztgenannten Geräten hat eine internationale Zusammenarbeit zwischen Dermatologen und Chemikern gezeigt, dass sie bei zahlreichen Diabetikern schwere ACD verursachen, indem sie Isobornylacrylat bzw. N,N’-Dimethylacrylamid freisetzen. Eine verbesserte und vollständige Deklaration der Inhaltsstoffe für Produkte alle Art – und nicht nur, wie wir es derzeit in Europa haben, bei Kosmetika (abgesehen von der vollständigen Auflistung der Duftstoffe) – muss auf die legislative Agenda gesetzt werden.

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“…Carvone (L-carvone), a mint flavour in spearmint oil, is considered a weak skin sensitizer, allergy being linked to oral/perioral signs and oral lichen planus. In the Malmö clinic, 147 out of 4221 referred patients had a positive patch test to carvone; 73% had oral signs and 57% had oral lichen [87]. A Spanish patient was found sensitised to cinnamal present in her denture fixative cream [88].…”

Section: Fragrancesmentioning

confidence: 99%

Contact Allergy—Emerging Allergens and Public Health Impact

Uter

Werfel

Lepoittevin

et al. 2020

IJERPH

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Contact allergy (sensitisation) and allergic contact dermatitis (ACD) resulting from it have a considerable public health impact. For the present review, all pertinent articles were systematically searched via Medline and Web of Science™; additionally, all available issues of the journals “Contact Dermatitis” and “Dermatitis” were manually searched, covering the years 2018–2019, thereby extending and re-focusing a previous similar review. New allergens, or previously described allergens found in a new exposure context or of other current importance, are described in sections according to substance classes, e.g., metals, preservatives, fragrances. As a common finding in many investigations, a lack of information on product composition has been noted, for instance, regarding a newly described allergen in canvas shoes (dimethylthiocarbamylbenzothiazole sulfide) and, most notably, absence of co-operation from manufacturers of glucose-monitoring devices and insulin pumps, respectively. These latter devices have been shown to cause severe ACD in a considerable number of diabetic patients caused by the liberation of isobornyl acrylate and N,N’-dimethylacrylamide, respectively, as demonstrated by an international collaboration between dermatologists and chemists. Improved and complete ingredient labelling for all types of products, and not just as we have with cosmetics at present (apart from full listing of fragrance substances) in Europe, must be put on the legislative agenda.

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Carvone Contact Allergy in Southern Sweden: A 21-year Retrospective Study

Cited by 21 publications

References 22 publications

What is in? What is out? Updating the British Society for Cutaneous Allergy facial series*

What is in? What is out? Updating the British Society for Cutaneous Allergy facial series*

Kontaktallergien – Neu aufkommende Allergene und Auswirkungen für das Gesundheitswesen

Contact Allergy—Emerging Allergens and Public Health Impact

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