Carvedilol exhibits anti-acute T lymphoblastic leukemia effect in vitro and in vivo via inhibiting β-ARs signaling pathway

Xu, Yanpeng; Luo, Yan; Ma, Jinhua; Huang, Pei Yu; Chen, Yan; He, Zhixu

doi:10.1016/j.bbrc.2022.11.093

Cited by 2 publications

(2 citation statements)

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“…The expression and role of β-adrenergic receptors (β-ARs) were observed in T-ALL primary cells and cell lines such as Jurkat, CEM-C1, and CEM-C7. Xu and collaborators [25] recently showed that newly diagnosed T-ALL patients express higher levels of β1, β2, and β3-ARs than the control group. Using Carvedilol, a third-generation non-selective β-AR blocker, they observed inhibition of T-ALL viability in vitro and in vivo by the induction of apoptosis and arrest of the cell cycle.…”

Section: Thymus-brain Connections In T-allmentioning

confidence: 99%

“…Epinephrine and norepinephrine (adrenaline and noradrenaline, respectively) are hormones and neurotransmitters released from the adrenal glands, whereas norepinephrine is released from the sympathetic nerve terminals. They act through adrenergic receptors (ARs) present on many cell types, including developing T lymphocytes [51].…”

Section: Neurotransmitters Neuropeptides and Correlated Receptors In ...mentioning

confidence: 99%

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Thymus-brain connections in T-cell Acute Lymphoblastic Leukemia

Mendes-da-Cruz,

Belorio,

Cotta-de-Almeida

2024

Neuroimmunomodulation

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Background: T-cell acute lymphoblastic leukemia (T-ALL) is a malignant hematologic disease caused by the transformation and uncontrolled proliferation of T-cell precursors. T-ALL is generally thought to originate in the thymus since lymphoblasts express phenotypic markers comparable to those described in thymocytes in distinct stages of development. Although around 50% of T-ALL patients present a thymic mass, T-ALL is characterized by peripheral blood and bone marrow involvement, and central nervous system (CNS) infiltration is one of the most severe complications of the disease. Summary: The CNS invasion is related to the expression of specific adhesion molecules and receptors commonly expressed in developing T cells, such as L-selectin, CD44, integrins, and chemokine receptors. Furthermore, T-ALL blasts also express neurotransmitters, neuropeptides and cognate receptors that are usually present in the CNS and can affect both the brain and thymus, participating in the crosstalk between the organs. Key messages: This review discusses how the thymus-brain connections, mediated by innervation and common molecules and receptors, can impact the development and migration of T-ALL blasts, including CNS infiltration.

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Section: Thymus-brain Connections In T-allmentioning

confidence: 99%

Section: Neurotransmitters Neuropeptides and Correlated Receptors In ...mentioning

confidence: 99%