Carvacrol-rich plants in Turkey

Kırımer, N.; Başer, Kemal Hüsnü Can; Tümen, Gülendam

doi:10.1007/bf01167568

Cited by 75 publications

(54 citation statements)

References 22 publications

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“…CVL ( Fig. 1) (2-methyl-5-(1-methylethyl)-phenol) is a predominant monoterpenic phenol which occurs in many essential oils of the family Labiatae including Origanum, Satureja, Thymbra, Thymus, and Coridothymus species [17]. Generally recognised as a safe food additive, CVL is used as a flavouring agent in sweets, beverages and chewing gums [18].…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Combination of carvacrol and rosiglitazone ameliorates high fat diet induced changes in lipids and inflammatory markers in C57BL/6J mice

2015

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Section: Introductionmentioning

confidence: 99%

RETRACTED: Combination of carvacrol and rosiglitazone ameliorates high fat diet induced changes in lipids and inflammatory markers in C57BL/6J mice

2015

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“…Carvacrol (CARV) is the predominant monoterpenic phenol in many essential oils of the family Labiatae including Origanum, Satureja, Thymbra, Thymus and Corydothymus species which have been used through the ages as a source of flavour in food [13]. Previous studies have demonstrated that CARV promoted inhibition of cyclooxygenase [14].…”

mentioning

confidence: 99%

Bioassay‐guided Evaluation of Antioxidant and Antinociceptive Activities of Carvacrol

Guimarães

Oliveira

Melo

et al. 2010

Basic Clin Pharma Tox

189

135

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We examined the antioxidant properties in vitro and the antinociceptive effect of carvacrol (CARV) in several models of pain in mice. CARV presented a strong antioxidant potential according to the TRAP ⁄ TAR evaluation; it also presented scavenger activity against nitric oxide and prevented lipid peroxidation in vitro. In mice, when evaluated against acetic acidinduced abdominal writhing, CARV (25, 50 and 100 mg ⁄ kg, i.p.) reduced (p < 0.001) the number of writhing compared to the control group, without opioid participation. In the formalin test, CARV also significantly inhibited both the early (neurogenic pain) and the late (inflammatory pain) phases of formalin-induced licking, with inhibition percentage values of 56.8% (100 mg ⁄ kg) for the neurogenic phase and 41.2% (25 mg ⁄ kg), 73.8% (50 mg ⁄ kg) and 99.7% (100 mg ⁄ kg) for the inflammatory phase. CARV also produced a significant inhibition of the pain caused by capsaicin (63.1, 67.1 and 95.8%, p < 0.001) and glutamate (46.4, 61.4 and 97.9%, p < 0.01). When assessed in a thermal model of pain, CARV (100 mg ⁄ kg, i.p.) caused a significant increase (p < 0.05) in the latency response on the hot-plate test. Such results were unlikely to be provoked by motor abnormality. Together, these results indicate that the properties of CARV should be more thoroughly examined in order to achieve newer tools for management and ⁄ or treatment of painful conditions, including those related to pro-oxidant states.

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“…Carvacrol or cymophenol (2-methyl-5-isopropyl phe- nol) is a predominant monoterpenic phenol which occurs in many essential oil of the family Labiatae including Origanum satureja, Thymbra, Thymus and Corydothymus species [19,20]. Carvacrol knows as a strong antioxidant has an antioxidant characteristic that its characteristic is similar to vitamin E, C and butyl hydroxyl toluene (BHT) [21,22].…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Carvacrol on Renal Functional and Histopathological Changes in Gentamicin-Induced-Nephrotoxicity in Rats

Ahmadvand

Tavafi

Asadollahi

et al. 2016

Zahedan J Res Med Sci

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Background: Nephrotoxicity is one of the most important side effects of the use of gentamicin sulphate (GS) resulted in reactive oxygen species generation. Antioxidant compounds played effective roles in reduction of renal injuries caused by using of gentamicin. Carvacrol is a strong antioxidant compound. Objectives: The aim of this study is to explore the effect of carvacrol inhibition in lesions of gentamicin-induced nephrotoxicity. Materials and Methods:In this experimental study, 32 male mature Sprague-Dawley rats were divided into 4 groups of 8; group1: control, group 2 sham received daily carvacrol injection (74 mg/kg) for 12 days, group 3 received daily GS injection (100 mg/kg) for 12 days, group 4 received daily GS (100 mg/kg) and carvacrol (74 mg/kg) for 12 days. After 12 days, rats were anaesthetized, blood sample were obtained and kidneys were removed then stained with hematoxylin and eosin method and then were studied histophatologically. Serum creatinine and urea were measured. Results: Flow treatment of nephrotoxic animals with carvacrol could significantly inhibit leukocyte infiltration (9.42%) and tubular necrosis (38.18%) in comparison with the nephrotoxic untreated group. Carvacrol significantly decreased the levels of urea and creatinine in treated group compared with the nephrotoxic untreated group. Conclusions: The findings showed that carvacrol alleviates loss of leukocyte infiltration (9.42%) and tubular necrosis and exerts beneficial effects on kidney function test in nephrotoxic group.

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Carvacrol-rich plants in Turkey

Cited by 75 publications

References 22 publications

RETRACTED: Combination of carvacrol and rosiglitazone ameliorates high fat diet induced changes in lipids and inflammatory markers in C57BL/6J mice

RETRACTED: Combination of carvacrol and rosiglitazone ameliorates high fat diet induced changes in lipids and inflammatory markers in C57BL/6J mice

Bioassay‐guided Evaluation of Antioxidant and Antinociceptive Activities of Carvacrol

Protective Effect of Carvacrol on Renal Functional and Histopathological Changes in Gentamicin-Induced-Nephrotoxicity in Rats

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