Carvacrol exerts nephroprotective effect in rat model of diclofenac-induced renal injury through regulation of oxidative stress and suppression of inflammatory response

Nouri, Ali; Izak-Shirian, Farzad; Fanaei, Vahideh; Dastan, Maryam; Abolfathi, Mahdieh; Moradi, Alireza; Khaledi, Mansoor; Mirshekari-Jahangiri, Hamzeh

doi:10.1016/j.heliyon.2021.e08358

Cited by 9 publications

(5 citation statements)

References 44 publications

(57 reference statements)

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“…High levels of these cytokines may rely on diclofenac-induced NF-κB activation [54]. Furthermore, it has been proven by Nouri et al that exposure to diclofenac significantly activates the TNF-α expression in renal tissue [16], and it may cause mononuclear cell infiltration, promoting a long-lasting inflammatory process [62]. Taken together, these mechanisms may corroborate the deleterious impacts of diclofenac documented by our publication.…”

Section: Discussionsupporting

confidence: 85%

“…In recent years, there has been a growing trend in scientific research focused on food supplements and medical herbs, with numerous studies aiming to identify treatments that can modulate human diseases [14]. Several natural antioxidants and plant extracts are effective in protecting the kidney from diclofenacinduced damage, including Carvacrol, Caffeine, Cinammoun aqueous extract, Aframomum melegueta seeds extract, Hesperidin Methyl Chalcone, Chlorophyll and vitamin D 3 [15][16][17][18][19][20]. Additionally, a new series of compounds, namely 5-substituted-1,3,4-thiadiazole-2thiols (3a-m) and 5-substituted-2-(3,4,5-tri hydroxyphenyl)-1,3,4-oxadiazoles (3n-z), was synthesized and assessed for its in vitro antioxidant activities.…”

Section: Introductionmentioning

confidence: 99%

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Histological Assessment of Selenium Protective Effect Against Diclofenac Sodium-Induced Nephrotoxicity in Rats

Albassit

Laham

Al-Manadili

2023

J. Pharm. Nutr. Sci.

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Drug-induced nephrotoxicity is a matter of global significance, with widespread implications for human health. Non-steroidal anti-inflammatory drugs (NSAIDs), such as Diclofenac Sodium, are widely used but have been associated with numerous adverse effects, including those on the gastrointestinal tract, liver, and kidney. Selenium, an essential element in mammalian biology, has demonstrated antioxidant properties that enable it to antagonize the effects of free radicals. The present study aimed to investigate the potential protective effect of Selenium against Diclofenac Sodium-induced nephrotoxicity in rats. The study sample consisted of 32 male albino Wistar rats and was randomly divided into 4 groups: Control group, Diclofenac group (Dic group) (administered at a dose of 50 mg/kg I.M., for 3 days), Selenium group (Se group) (administered at a dose of 1 mg/kg I.P., for 8 days), and Diclofenac plus Selenium group (Dic + Se group). Rats were sacrificed on the 9th day. The results were analyzed with a significance level of p<0.05. The findings revealed significant tubular and glomerular injuries in the Diclofenac group compared to the control group. However, there was no statistically significant improvement observed in the Dic + Se group. In conclusion, the results of this study suggest that Selenium affords partial protection against Diclofenac Sodium-induced nephrotoxicity, but it is not sufficient to provide complete protection.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Histological Assessment of Selenium Protective Effect Against Diclofenac Sodium-Induced Nephrotoxicity in Rats

Albassit

Laham

Al-Manadili

2023

J. Pharm. Nutr. Sci.

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“…42 Recent studies have proven the anti-inflammatory activity of CVL by modulating TNF-α, IL-1β, and NF-κB expression in rat models of diclofenac-induced kidney injury and thioacetamide-induced hepatic fibrosis. 43,44 In the current study, UUO-induction dramatically increased the renal recruitment of inflammatory cells and the pro-inflammatory cytokines TNF-α and IL-1β in the obstructed kidneys. However, we observed a marked decrease in inflammatory cell infiltration and low levels of TNF-α and IL-1β in the obstructed kidneys after CVL administration.…”

Section: Discussionsupporting

confidence: 50%

Carvacrol preserves antioxidant status and attenuates kidney fibrosis via modulation of TGF-β1/Smad signaling and inflammation

et al. 2022

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“…Aside from the studies presented in Table 5, many others were found in the bibliographic search reporting the anti-inflammatory activity of monoterpenes by evaluating the expression of pro-inflammatory and/or anti-inflammatory mediators, as these are the most common endpoints found in the inflammatory response. Examples include carvacrol [165][166][167][168], 1,8-cineole [169,170], citral [171,172], isopulegol [173], linalool [174,175], linalyl acetate [174] and thymol [176][177][178].…”

Section: Geraniolmentioning

confidence: 99%

Plant Monoterpenes and Essential Oils as Potential Anti-Ageing Agents: Insights from Preclinical Data

Zuzarte,

Sousa,

Alves-Silva

et al. 2024

Biomedicines

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Ageing is a natural process characterized by a time-dependent decline of physiological integrity that compromises functionality and inevitably leads to death. This decline is also quite relevant in major human pathologies, being a primary risk factor in neurodegenerative diseases, metabolic disorders, cardiovascular diseases and musculoskeletal disorders. Bearing this in mind, it is not surprising that research aiming at improving human health during this process has burst in the last decades. Importantly, major hallmarks of the ageing process and phenotype have been identified, this knowledge being quite relevant for future studies towards the identification of putative pharmaceutical targets, enabling the development of preventive/therapeutic strategies to improve health and longevity. In this context, aromatic plants have emerged as a source of potential bioactive volatile molecules, mainly monoterpenes, with many studies referring to their anti-ageing potential. Nevertheless, an integrated review on the current knowledge is lacking, with several research approaches studying isolated ageing hallmarks or referring to an overall anti-ageing effect, without depicting possible mechanisms of action. Herein, we aim to provide an updated systematization of the bioactive potential of volatile monoterpenes on recently proposed ageing hallmarks, and highlight the main mechanisms of action already identified, as well as possible chemical entity–activity relations. By gathering and categorizing the available scattered information, we also aim to identify important research gaps that could help pave the way for future research in the field.

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Carvacrol exerts nephroprotective effect in rat model of diclofenac-induced renal injury through regulation of oxidative stress and suppression of inflammatory response

Cited by 9 publications

References 44 publications

Histological Assessment of Selenium Protective Effect Against Diclofenac Sodium-Induced Nephrotoxicity in Rats

Histological Assessment of Selenium Protective Effect Against Diclofenac Sodium-Induced Nephrotoxicity in Rats

Carvacrol preserves antioxidant status and attenuates kidney fibrosis via modulation of TGF-β1/Smad signaling and inflammation

Plant Monoterpenes and Essential Oils as Potential Anti-Ageing Agents: Insights from Preclinical Data

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