Carvacrol effectively protects demyelination by suppressing transient receptor potential melastatin 7 (TRPM7) in Schwann cells

Chun, Yoo Lim; Kim, Muwoong; Kim, Young Hwa; Kim, Nahyeon; Yang, Hyejin; Park, Chan; Huh, Youngbuhm; Jung, Junyang

doi:10.1007/s12565-019-00514-1

Cited by 5 publications

(4 citation statements)

References 20 publications

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Section: Therapeutic Perspectivesmentioning

confidence: 99%

“…Carvacrol significantly suppressed the morphometric indices, such as myelin, stripe, ovoid, and neurofilament indices. Moreover, carvacrol inhibited TRPM7 upregulation in Schwann cells and protected against the peripheral neurodegenerative process(Chun et al, 2019).Carvacrol also protects from 6-hydroxydopamine-induced neurotoxicity as evidenced by various studies on Parkinson's disease;Manouchehrabadi et al (2019) investigated the neuroprotective effects of carvacrol on Parkinson's disease models in in vitro and in vivo experiments. In in vitro experiment, post-treatment carvacrol protects the adrenal pheochromocytoma PC12 cells of animals from 6-hydroxydopamine-induced neurotoxicity by toxicity induced by a reduction in intracellular reactive oxygen species, increasing cell viability and reduced intra-cellular lipid In peroxidation In and In annexin In positive In cells In.…”

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confidence: 99%

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Therapeutic application of carvacrol: A comprehensive review

Imran¹,

Aslam

Alsagaby

et al. 2022

Food Science & Nutrition

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Carvacrol is a major natural constituent and is significantly present as an essential oil in aromatic plants and is well known for its numerous biological activities. Therapeutic properties of carvacrol have been demonstrated as anti‐oxidant, anticancer, diabetes prevention, cardioprotective, anti‐obesity, hepatoprotective and reproductive role, antiaging, antimicrobial, and immunomodulatory properties. The carvacrol biosynthesis has been mediated through mevalonate pathway. Carvacrol has the anticancer ability against malignant cells via decreasing the expressions of matrix metalloprotease 2 and 9, inducing apoptosis, enhancing the expression of pro‐apoptotic proteins, disrupting mitochondrial membrane, suppressing extracellular signal‐regulated kinase 1/2 mitogen‐activated protein kinase signal transduction, and also decreasing the phosphoinositide 3‐kinase/protein kinase B. It also decreased the concentrations of alanine aminotransferase, alkaline phosphatase and aspartate aminotransferase, and gamma‐glutamyl transpeptidase as well as also restored liver function, insulin level, and plasma glucose level. Carvacrol also has been found to exert antimicrobial activity against Staphylococcus aureus, Pseudomonas aeruginosa, Coagulase‐negative staphylococcus, Salmonella spp., Enterococcus sp. Shigella, and Escherichia coli. The current review article summarizes the health‐promoting perspectives of carvacrol through various pathways.

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Section: Therapeutic Perspectivesmentioning

confidence: 99%

mentioning

confidence: 99%

Therapeutic application of carvacrol: A comprehensive review

Imran¹,

Aslam

Alsagaby

et al. 2022

Food Science & Nutrition

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“…Carvacrol is a liquid phenolic monoterpenoid that is a major component of oil extracted from the flowers and leaves of Origanum vulgare and Thymus vulgaris (Angienda and Hill 2011). Previous studies have shown that carvacrol specifically decreases TRPM7 expression in injured Schwann cells (Chubanov et al 2014;Chun et al 2020). To investigate whether TRPM7 is involved in Schwann cell trans-dedifferentiation and proliferation during Wallerian degeneration, we used carvacrol (3 mM) as a specific inhibitor of TRPM7 expression in an ex vivo culture system (Chun et al 2020).…”

Section: Resultsmentioning

confidence: 99%

“…Several studies have shown that TRPs can alleviate abnormal conditions in the nervous system (Chen et al 2015a , 2015b ; Logu et al, 2017 ; Peters et al, 2012 ). In the PNS, Schwann cells are involved with TRPA1 and TRPM7, whereas during Wallerian degeneration, only TRPM7 expression increases (Logu et al, 2017 ; Chun et al 2020 ). Therefore, control of TRPM7 expression could be an effective method for regulating Wallerian degeneration.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of transient receptor potential melastatin 7 (TRPM7) protects against Schwann cell trans-dedifferentiation and proliferation during Wallerian degeneration

Kim

Lee

Yang

et al. 2020

Animal Cells and Systems

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Irreversible peripheral neurodegenerative diseases such as diabetic peripheral neuropathy are becoming increasingly common due to rising rates of diabetes mellitus; however, no effective therapeutic treatments have been developed. One of main causes of irreversible peripheral neurodegenerative diseases is dysfunction in Schwann cells, which are neuroglia unique to the peripheral nervous system (PNS). Because homeostasis of calcium (Ca 2+) and magnesium (Mg 2+) is essential for Schwann cell dynamics, the regulation of these cations is important for controlling peripheral nerve degeneration and regeneration. Transient receptor potential melastatin 7 (TRPM7) is a non-selective ion (Ca 2+ and Mg 2+) channel that is expressed in Schwann cells. In the present study, we demonstrated in an ex vivo culture system that inhibition of TRPM7 during peripheral nerve degeneration (Wallerian degeneration) suppressed dedifferentiable or degenerative features (trans-dedifferentiation and proliferation) and conserved a differentiable feature of Schwann cells. Our results indicate that TRPM7 could be very useful as a molecular target for irreversible peripheral neurodegenerative diseases, facilitating discovery of new therapeutic methods for improving human health.

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