Carvacrol Ameliorates Ligation‐Induced Periodontitis in Rats

Kuo, Po-Jan; Hung, Tsung-Fu; Lin, Chia-Cheng; Hsiao, Hsiang-Yin; Fu, Mengdi; Hong, Po‐Da; Chiu, Hsien‐Chung; Fu, Earl

doi:10.1902/jop.2017.160618

Cited by 12 publications

(11 citation statements)

References 45 publications

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“…The administration of αTPN‐βCD reduced gingival levels of MDA (indicator of oxidative stress) and MPO (indirect marker of neutrophil cell infiltrate), as well as the inflammatory infiltrate score in the furcation region. Similar to another terpene, carvacrol, which caused a decrease in bone resorption in periodontitis model, significantly reduced levels of tumor necrosis factor‐α, interleukin‐1β, interleukin‐6, inducible nitric oxide synthase, and matrix metalloproteinase 2 and 9 in oral tissues 27 . In addition, curcumol, another terpene, reduced the osteoclast formation, suppressed receptor activator of nuclear factor kappaB ligand (RANKL)‐induced osteoclast differentiation through the c‐Jun N‐terminal kinase (JNK)/activator protein‐1 JNK/AP‐1 signaling pathway 28 .…”

Section: Discussionmentioning

confidence: 93%

“…*P < .05 vs control group and # P < .05 vs the periodontitis group carvacrol, which caused a decrease in bone resorption in periodontitis model, significantly reduced levels of tumor necrosis factor-α, interleukin-1β, interleukin-6, inducible nitric oxide synthase, and matrix metalloproteinase 2 and 9 in oral tissues. 27 In addition, curcumol, another terpene, reduced the osteoclast formation, suppressed receptor activator of nuclear factor kappaB ligand (RANKL)-induced osteoclast differentiation through the c-Jun N-terminal kinase (JNK)/activator protein-1 JNK/AP-1 signaling pathway. 28 We believe that αTPN-βCD can act similarly, due to the fact that the treatment with αTPN-βCD reduces the number of osteoclasts per surface area ( Figure 3O).…”

Section: Discussionmentioning

confidence: 99%

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Alpha‐terpineol complexed with beta‐cyclodextrin reduces damages caused by periodontitis in rats

Vasconcelos

Vasconcelos²,

Silva³

et al. 2020

J of Periodontal Research

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Background and objective: This study aimed to assess the effectiveness of the treatment with alpha-terpineol (αTPN) complexed with beta-cyclodextrin (βCD) on oral, blood, and hepatic parameters in ligature-induced periodontitis. Material and Methods: Forty female rats were distributed among the following groups: control (vehicle solution), periodontitis (ligature + vehicle solution), 5 mg/kg of αTPN-βCD (ligature), and 25 mg/kg of αTPN-βCD (ligature). Compounds were administered daily via intraperitoneal injection over a 20-day period. Periodontitis was induced with the bilateral insertion of ligatures around the first lower molars of each rat. Oral parameters, as well as blood biomarkers, were measured: histopathological assessment of the hepatic tissue was carried out using light and transmission electron microscopy. Results: The treatment with αTPN-βCD significantly improved several oral parameters and blood biomarkers in comparison with rats with periodontitis. In addition, the treatment with αTPN-βCD significantly ameliorated the steatosis score and reduced the number of lipid droplets and the amount of foamy cytoplasm in the hepatocytes of rats with periodontitis. Conclusion: The results obtained suggest that the treatment with αTPN-βCD improves several oral and blood parameters in rats with experimental periodontitis. In addition, hepatic alterations caused by periodontitis were ameliorated in the rats treated with αTPN-βCD.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Alpha‐terpineol complexed with beta‐cyclodextrin reduces damages caused by periodontitis in rats

Vasconcelos

Vasconcelos²,

Silva³

et al. 2020

J of Periodontal Research

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“…A study by Bothelo et al (2009) showed that local treatment with carvacrol gel significantly inhibited bone resorption in the alveolar bone of rats with experimentally induced periodontal disease. The topical application of carvacrol gel also inhibited the multiplication of periodontal microorganisms in these animal models [102].…”

Section: Anti-osteoclastic Properties Of Carvacrol and Magnololmentioning

confidence: 85%

“…The results showed that carvacrol protects gingival tissue in rats with periodontal disease, which is mediated by carvacrol through the inhibitory effect on inflammation and degradation of periodontal tissue. Carvacrol also reduces the inflammatory reaction and expression of MMP-9 [102]. Other studies have used carvacrol incorporated into herbal periodontal gels to treat experimentally induced periodontitis in rats and it has been shown that local application of carvacrol has reduced alveolar bone resorption [103,104].…”

Section: Biological Activities Of Carvacrol and Magnolol On Periodontitis And Diabetesmentioning

confidence: 99%

“…tal tissue. Carvacrol also reduces the inflammatory reaction and expression of MMP-9 [102]. Other studies have used carvacrol incorporated into herbal periodontal gels to treat experimentally induced periodontitis in rats and it has been shown that local application of carvacrol has reduced alveolar bone resorption [103,104].…”

Section: Anti-inflammatory Effects Of Carvacrol and Magnololmentioning

confidence: 99%

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Anti-Inflammatory and Antioxidant Properties of Carvacrol and Magnolol, in Periodontal Disease and Diabetes Mellitus

et al. 2021

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Periodontal disease and diabetes mellitus are two pathologies that are extremely widespread worldwide and share the feature of chronic inflammation. Carvacrol is a phenolic monoterpenoid, produced by a variety of herbs, the most well-known of which is Origanum vulgare. Magnolol is a traditional polyphenolic compound isolated from the stem bark of Magnolia officinalis, mainly used in Chinese medicine. The purpose of this paper is to review the therapeutic properties of these bioactive compounds, in the treatment of periodontitis and diabetes. Based on our search strategy we conducted a literature search in the PubMed and Google Scholar databases to identify studies. A total of one hundred eighty-four papers were included in the current review. The results show that carvacrol and magnolol have anti-inflammatory, antioxidant, antimicrobial, anti-osteoclastic, and anti-diabetic properties that benefit both pathologies. Knowledge of the multiple activities of carvacrol and magnolol can assist with the development of new treatment strategies, and the design of clinical animal and human trials will maximize the potential benefits of these extracts in subjects suffering from periodontitis or diabetes.

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Carvacrol suppresses inflammatory responses in rheumatoid arthritis fibroblast‐like synoviocytes

et al. 2018

J of Cellular Biochemistry

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Background Fibroblast‐like synoviocytes (FLSs) play an essential role in the chronic inflammatory process of rheumatoid arthritis (RA). Carvacrol is a natural monoterpenic phenol that retains significant anti‐inflammatory activity. However, the effect of carvacrol on inflammatory response in RA‐FLSs has not yet been reported. The present study aimed to investigate the role of carvacrol in lipopolysaccharides (LPS)‐induced inflammatory response in human RA‐FLSs. Methods Cell viability and proliferation were measured by MTT and Cell Counting Kit‐8 assays, respectively. The migration was detected by transwell assay. The production of inflammatory cytokines and matrix metalloproteinases (MMPs) were analyzed by enzyme‐linked immunosorbent assay. The expressions of toll‐like receptor 4 (TLR4), myeloid differentiation primary response 88 (MyD88), NF‐κB, p38, p‐p38, ERK1/2, p‐ERK1/2, c‐Jun N‐terminal kinase (JNK), and p‐JNK were detected by Western blot analysis. Results Carvacrol‐inhibited LPS‐induced cell proliferation and migration of RA‐FLSs. The production of inflammatory cytokines, including tumor necrosis factor alpha, interleukin (IL)− 6, and IL‐8, was reduced by carvacrol in LPS‐induced RA‐FLSs. Meanwhile, the induction of MMPs, including MMP‐1, MMP‐3, and MMP‐13, caused by LPS stimulation was inhibited by carvacrol in RA‐FLSs. Furthermore, carvacrol prevented LPS‐induced activation of the TLR4/MyD88/NF‐κB, p38, and ERK1/2 pathways in RA‐FLSs. Conclusions Carvacrol‐mitigated LPS‐induced cell proliferation, migration, and inflammation in RA‐FLSs. The TLR4/MyD88/NF‐κB, p38 and ERK1/2 pathways might be involved in the protective effect of carvacrol.

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Carvacrol Ameliorates Ligation‐Induced Periodontitis in Rats

Abstract: Carvacrol reduced tissue damage and bone loss caused by ligation-induced periodontitis. The present results indicate that carvacrol might reduce tissue destruction by downregulating expression of proinflammatory mediators and MMP-9.

Cited by 12 publications

References 45 publications

Alpha‐terpineol complexed with beta‐cyclodextrin reduces damages caused by periodontitis in rats

Alpha‐terpineol complexed with beta‐cyclodextrin reduces damages caused by periodontitis in rats

Anti-Inflammatory and Antioxidant Properties of Carvacrol and Magnolol, in Periodontal Disease and Diabetes Mellitus

Carvacrol suppresses inflammatory responses in rheumatoid arthritis fibroblast‐like synoviocytes

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