Cartography of hevin-expressing cells in the adult brain reveals prominent expression in astrocytes and parvalbumin neurons

Abstract

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Blood–Brain Barrier Degradation and the Implication of SPARC Protein as a Potential Therapeutic Target for Alzheimer’s Disease

“…The proteins are primarily expressed in immune cells. While both SPARC and Hevin are produced by microglia (7) and astrocytes (61), Hevin is produced only by some neurons (62). Postmortem examination of the brains of AD and control individuals found that there is a notable upregulation of SPARC and downregulation of Hevin in the AD brains.…”

Interplay between hevin, SPARC, and MDGAs: Modulators of neurexin-neuroligin transsynaptic bridges

“…Throughout postnatal development, hevin is abundantly expressed in astrocytes and in subsets of projection neurons, escalating to high levels during a peak period of synaptic remodeling (Lively and Brown, 2008a;Lloyd-Burton and Roskams, 2012;Mendis et al, 1996;Risher et al, 2014). However, hevin is also strongly expressed in many regions in adult brain in most astrocytes, and also in select populations of inhibitory and excitatory neurons (Hashimoto et al, 2016;Lively et al, 2007;Lloyd-Burton and Roskams, 2012;Mendis et al, 1996;Mongré dien et al, 2019;Risher et al, 2014). Like hevin, SPARC is broadly expressed during development in glial cells and radial glia (progenitor cells that additionally function as guide cells along which neurons migrate) (Vincent et al, 2008), but in adult CNS, SPARC is expressed only in very limited regions by astrocytes and microglia but not neurons (Lloyd-Burton and Roskams, 2012;Mendis et al, 1995;Mongré dien et al, 2019;Vincent et al, 2008).…”

“…However, hevin is also strongly expressed in many regions in adult brain in most astrocytes, and also in select populations of inhibitory and excitatory neurons (Hashimoto et al, 2016;Lively et al, 2007;Lloyd-Burton and Roskams, 2012;Mendis et al, 1996;Mongré dien et al, 2019;Risher et al, 2014). Like hevin, SPARC is broadly expressed during development in glial cells and radial glia (progenitor cells that additionally function as guide cells along which neurons migrate) (Vincent et al, 2008), but in adult CNS, SPARC is expressed only in very limited regions by astrocytes and microglia but not neurons (Lloyd-Burton and Roskams, 2012;Mendis et al, 1995;Mongré dien et al, 2019;Vincent et al, 2008). Given the high sequence identity, the striking biological differences between hevin and SPARC remain puzzling, especially as they also seem to share certain functions, as described above, and this dichotomy is important given the characteristic temporal and spatial expression patterns of hevin and SPARC.…”

Developmental onset of enduring long‐term potentiation in mouse hippocampus

“…The cause of FXS is the mutation preventing the synthesis of FMRP, an RNA‐binding protein selectively expressed in neurons and responsible for mRNA transport and local protein synthesis in dendrites (Wang et al, 2016). Hevin is a protein released by astrocytes and interneurons that is critical for synapse formation and rearrangement (Mongredien et al, 2019). The synaptogenic activity of Hevin promotes glutamatergic synapse maturation and refines cortical connectivity and plasticity (Risher et al, 2014; Singh et al, 2016).…”