Cartilage T2 Assessment: Differentiation of Normal Hyaline Cartilage and Reparative Tissue after Arthroscopic Cartilage Repair in Equine Subjects

White, Lawrence M.; Sussman, Marshall S.; Hurtig, Mark; Probyn, Linda; Tomlinson, George; Kandel, Rita A.

doi:10.1148/radiol.2412051750

Cited by 169 publications

(173 citation statements)

References 52 publications

(74 reference statements)

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“…Consistent with previous results in healthy knee [51,52], the mean TSD T2 value was 37.0 ± 6.8 ms. Because 95% of values should be smaller than (mean ± SD), 50 was chosen as the threshold above which T2 values were considered inordinately high. To quantify T2 mapping, a Poor Cartilage Index (PCI) was estimated as the percentage of T2 values larger than 50 ms. A PCI of 100 is the worst possible value, and a value near 5 is considered healthy.…”

Section: Cartilage Mrisupporting

confidence: 92%

See 1 more Smart Citation

Treatment of Knee Osteoarthritis with Autologous Expanded Bone Marrow Mesenchymal Stem Cells: 50 Cases Clinical and MRI Results at One Year Follow-Up

R¹,

Munar²,

F³

et al. 2015

J Stem Cell Res Ther

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Section: Cartilage Mrisupporting

confidence: 92%

“…T2 relaxation time is sensitive to both changes in cartilage hydration and collagen fibril orientation [51,52].…”

Section: Cartilage Mrimentioning

confidence: 99%

Treatment of Knee Osteoarthritis with Autologous Expanded Bone Marrow Mesenchymal Stem Cells: 50 Cases Clinical and MRI Results at One Year Follow-Up

R¹,

Munar²,

F³

et al. 2015

J Stem Cell Res Ther

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“…The results of White et al 13 were encouraging. These investigators performed OAT and MFX in horses, and were able to correlate a zonal increase in cartilage T2 values from near the subchondral bone to near the cartilage surface to histology and collagen structural anisotropy, as assessed by polarized light microscopy.…”

Section: Discussionmentioning

confidence: 88%

“…11 In cartilage repair tissue, histologically validated animal studies report this increase in zonal T2 as an indicator of hyaline or ''hyaline-like'' cartilage composition. 12,13 The aim of this study was to evaluate if in vivo mean (full-thickness) as well as zonal (deep and superficial) quantitative T2 assessment in patients after MACT is capable to visualize the maturation of the cartilage repair tissue.…”

mentioning

confidence: 99%

Quantitative T2 mapping during follow‐up after matrix‐associated autologous chondrocyte transplantation (MACT): Full‐thickness and zonal evaluation to visualize the maturation of cartilage repair tissue

Welsch

Mamisch

Marlovits

et al. 2009

Journal Orthopaedic Research

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The purpose of this article was to evaluate the potential of in vivo zonal T2-mapping as a noninvasive tool in the longitudinal visualization of cartilage repair tissue maturation after matrix-associated autologous chondrocyte transplantation (MACT). Fifteen patients were treated with MACT and evaluated cross-sectionally, with a baseline MRI at a follow-up of 19.7 AE 12.1 months after cartilage transplantation surgery of the knee. In the same 15 patients, 12 months later (31.7 AE 12.0 months after surgery), a longitudinal 1-year followup MRI was obtained. MRI was performed on a 3 Tesla MR scanner; morphological evaluation was performed using a double-echo steadystate sequence; T2 maps were calculated from a multiecho, spin-echo sequence. Quantitative mean (full-thickness) and zonal (deep and superficial) T2 values were calculated in the cartilage repair area and in control cartilage sites. A statistical analysis of variance was performed. Full-tickness T2 values showed no significant difference between sites of healthy cartilage and cartilage repair tissue (p < 0.05). Using zonal T2 evaluation, healthy cartilage showed a significant increase from the deep to superficial cartilage layers (p < 0.05). Cartilage repair tissue after MACT showed no significant zonal increase from deep to superficial cartilage areas during baseline MRI (p > 0.05); however, during the 1-year follow-up, a significant zonal stratification could be observed (p < 0.05). Morphological evaluation showed no significant difference between the baseline and the 1-year follow-up MRI. T2 mapping seems to be more sensitive in revealing changes in the repair tissue compared to morphological MRI. In vivo zonal T2 assessment may be sensitive enough to characterize the maturation of cartilage repair tissue. ß

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“…Several studies focused on evaluating cartilage repair using different animal models including sheep, horse and goat [13,[27][28][29] . A specialized characteristic of rodents and lagomorphs is that they possess auto-intrinsic repair of cartilage which is not present in larger animal and human [30] .…”

Section: Discussionmentioning

confidence: 99%

Tavşanlarda Artikular Kartilaj Defekt Onarımında Devekuşu Plantar Ligament Kökenli Hücre İçermeyen Matriks Doku Kullanımı

Moridpour¹,

Fattahian²,

Mortazavi³

2017

Kafkas Univ Vet Fak Derg

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Citation of This ArticleMoridpour R, Fattahian HR, Mortazavi P: Using cell-free matrix derived from ostrich plantar ligament for repair of articular cartilage defect of rabbit. Kafkas Univ Vet Fak Derg, 23 (5): 707-713, 2017. DOI: 10.9775/kvfd.2017 Abstract Articular cartilage lesions are most common injury of the knee for which several repair methods have been described. We described in-vivo potential of collagen type I scaffold extracted fromknee of ostrich. Full thickness defects were created bilaterally in the weight bearing area of femoral condyles of the both femurs of 7 white New zealand adult male rabbits weighting 1800±100 g. The six left medial condyles as experimental group I were filled by using cell-free tissue and six right medial condyles of the same rabbit were treated by cell-tissue as experimental group II and the right medial condyle defect of one rabbit as control group was left without treatment. Histopathology data demonstrated significant difference between three groups with respect to the cartilage repair indicators as the morphology of the cells, color matrix and cartilage thickness (P<0.05). Furthermore, sub-chondral bone formation showed a significant difference and relationship between two experimental groups and control group (P<0.05). The use of cell-free ligamentum plantar matrix showed markedly significant improvement in the processes of joint cartilage repair compared control group (P<0.05). Results support the use of cell-free ligamentum plantar can be useful and promising bio-engineering procedure as a scaffold for the treatment of the articular cartilage surface. Keywords: Cell-free matrix, Ostrich plantar ligament, Repair, Articular cartilage defect, Rabbit Tavşanlarda Artikular Kartilaj Defekt Onarımında Devekuşu Plantar Ligament Kökenli Hücre İçermeyen Matriks Doku Kullanımı ÖzetArtikular kartilaj lezyonları dizin en sıklıkla gözlenen yaralanması olup birkaç onarım metodu tanımlanmıştır. Bu çalışmada devekuşunun dizinden ekstrakte edilen kollajen tip I doku iskelesinin in vivo potansiyeli tanımlanmıştır. Ağırlıkları 1800±100 g olan 7 adet Yeni Zelanda ergin erkek tavşanın her iki femurunda femoral kondulusların ağırlık taşıyan bölgelerinde bilateral olarak tüm kat hasarı oluşturuldu. Altı sol medial kondulus hücre içermeyen doku ile doldurulurken (Grup I) aynı tavşanların altı sağ medial kondulus hasarı hücre içeren doku ile tedavi edildi (Grup II) ve bir tavşanın sağ medial kondulus hasarı tedavi uygulanmayarak kontrol grubu olarak bırakıldı. Histopatoloji bulguları kartilaj onarım belirteçleri olarak hücre morfolojisi, renk matriks ve kartilaj kalınlığı bakımlarından her üç grup arasında anlamlı derecede fark olduğunu gösterdi (P<0.05). Ayrıca, subkondral kemik oluşumu iki deney grubu ile kontrol grubu arasında anlamlı derecede fark olduğunu göstermiştir (P<0.05). Hücre içermeyen ligamentum plantar matriks kullanımının kontrol grubu ile karşılaştırıldığında eklem kartilaj onarımında belirgin derecede iyileşme oluşturduğu gözlemlendi (P<0.05). Elde edilen sonuçlar hücre iç...

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Cartilage T2 Assessment: Differentiation of Normal Hyaline Cartilage and Reparative Tissue after Arthroscopic Cartilage Repair in Equine Subjects

Abstract: Qualitative and quantitative T2 mapping helped differentiate hyaline cartilage from reparative fibrocartilage after cartilage repair at 1.5-T MR imaging.

Cited by 169 publications

References 52 publications

Treatment of Knee Osteoarthritis with Autologous Expanded Bone Marrow Mesenchymal Stem Cells: 50 Cases Clinical and MRI Results at One Year Follow-Up

Treatment of Knee Osteoarthritis with Autologous Expanded Bone Marrow Mesenchymal Stem Cells: 50 Cases Clinical and MRI Results at One Year Follow-Up

Quantitative T2 mapping during follow‐up after matrix‐associated autologous chondrocyte transplantation (MACT): Full‐thickness and zonal evaluation to visualize the maturation of cartilage repair tissue

Tavşanlarda Artikular Kartilaj Defekt Onarımında Devekuşu Plantar Ligament Kökenli Hücre İçermeyen Matriks Doku Kullanımı

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