Abstract:Interleukin (IL)-10 overexpression inhibits joint infl ammation, however the effect of high local concentrations of IL-10 on chondrocyte homeostasis remains unclear. The aim of this study was to determine the effects of IL-10 overexpression on cartilage matrix production in three-dimensional (3D) chondrocyte cultures. Human articular chondrocytes were transduced with adenoviral vectors alone (adv/empty) or by vectors either overexpressing enhanced green fl uorescence protein (adv/EGFP) or human IL-10 (adv/hIL-… Show more
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