Cartilage quantification using contrast-enhanced MRI in the wrist of rheumatoid arthritis: cartilage loss is associated with bone marrow edema

Fujimori, Motoshi; Nakamura, Satoko; Hasegawa, Kiminori; Ikeno, Kunihiro; Ichikawa, Shota; Sutherland, Kenneth; Kamishima, Tamotsu

doi:10.1259/bjr.20170167

Cited by 7 publications

(5 citation statements)

References 18 publications

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“…The RA group also showed reduced cartilage thickness and amount of chondrocytes in the femur. Bone erosion associated with cartilage destruction are common radiological findings in patients with chronic RA, although cartilage damage seems to be more associated with physical disability (43). The aquatic resistance exercise protocol preserved the integrity of the tibial and femoral cartilage and promoted the permanence of fat cells in the synovial subintima, evidencing the need for exercise for joint maintenance.…”

Section: Discussionmentioning

confidence: 96%

Therapeutic Effect of Aquatic Resistance Exercise on Rectus Femoris and Knee in a Model of Rheumatoid Arthritis

Tavares¹,

Neves²,

Schnauffer³

et al. 2022

Muscle Ligaments and Tendons J

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Background. Rheumatoid Arthritis (RA) is characterized by progressive joint destruction due to an inflammatory, degenerative condition of the joint cartilage and adjacent muscles, impairing the patient's functional status. Resistance exercise is considered a good tool in the management of RA. The objective of this study was to evaluate the effect of resistance exercise, in an aquatic environment, on strength, motor control, and morphometric parameters of the rectus femoris muscle and knee joint of rats submitted to a model of RA. Methods. Forty male rats divided into four groups were used: CON (Control); RA (Injury Group); EX (Exercise Group) and EXRA (Injury Group treated with resistance exercise in aquatic environment). RA was induced by immunization at the base of the tail and intra-articular injection of Freund's Complete Adjuvant (CFA) in the tibio-femoral joint of the right knee. The exercise protocol was performed three times a week in a water tank with an overload of 50% of the animal's weight for 22 days, progressing the number of sets and repetitions every three treatments. Both pelvic limbs were evaluated for grip, motor control in the inclined plane, joint and muscle morphology, and their respective morphological measurements. Generalized Linear Models with LSD post-test was used for statistical analysis. Results. There was a reduction in strength of both pelvic limbs of the injured animals and the AR and EXRA groups also had morphological changes in the joint and in the rectus femoris muscle. The resistance exercise protocol in an aquatic environment helped to maintain strength and the quality of histological tissues. Conclusions. Resistance exercise in aquatic environment promoted functional and muscle tissue improvement in the knee joint of Wistar rats with RA with experimentally induced RA.

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Section: Discussionmentioning

confidence: 96%

Therapeutic Effect of Aquatic Resistance Exercise on Rectus Femoris and Knee in a Model of Rheumatoid Arthritis

Tavares¹,

Neves²,

Schnauffer³

et al. 2022

Muscle Ligaments and Tendons J

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“…Fujimori et al . proposed that bone marrow edema was associated with cartilage loss in RA. Herz et al .…”

Section: Discussionmentioning

confidence: 99%

Rheumatoid Arthritis of Knee Joints: MRI–Pathological Correlation

Meng

Zhi

Zhang

et al. 2018

Orthopaedic Surgery

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“…The hallmark features of RA are synovitis, tenosynovitis, and subchondral bone marrow inflammation that can lead to bone erosions, cartilage damage, and tendon tears. 3,4 The progression of structural damage in RA is associated with the development of joint deformity and eventually with disability. 4 This symmetrical polyarthritis generally involves the MCP, proximal intraphalangeal (PIP) joints, and the wrists.…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

“…3,4 The progression of structural damage in RA is associated with the development of joint deformity and eventually with disability. 4 This symmetrical polyarthritis generally involves the MCP, proximal intraphalangeal (PIP) joints, and the wrists. 3 Although characteristic bilateral symmetrical involvement of the joints and tendon sheaths of the hands and wrists is emphasized in several textbooks, it is observed mainly in advanced cases.…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

Rheumatoid Hand and Other Hand-deforming Rheumatic Conditions

Sudoł‐Szopińska

Teh

Cotten³

2021

Semin Musculoskelet Radiol

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The hand and wrist are commonly involved in rheumatic conditions, particularly rheumatoid arthritis and other systemic connective tissue diseases. With spondyloarthritis, hand and wrist involvement frequently occurs in psoriatic arthritis but generally does not occur in the remaining subtypes. The hand and wrist may also be affected in various metabolic and endocrine diseases, but these lie beyond the scope of this review.Radiographs may demonstrate the presence of joint space narrowing, bone loss, cysts and erosions, malalignments, and osteolysis. They may also show regions of soft tissue swelling or thinning, and detect calcifications. Ultrasonography and magnetic resonance imaging (MRI) enable evaluation of the soft tissues, particularly the synovium, tenosynovium, and tendons. Furthermore, erosions are better demonstrated than on radiographs. MRI allows evaluation of periarticular bone marrow edema.This article discusses typical imaging features of the hand and wrist in rheumatologic conditions including the advantages and limitations of the various methods.

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Cartilage quantification using contrast-enhanced MRI in the wrist of rheumatoid arthritis: cartilage loss is associated with bone marrow edema

Abstract: Our software can accurately quantify cartilage in the wrist and BME associated with cartilage loss in patients with RA. Advances in knowledge: Our software can quantify cartilage using conventional MR images of the wrist. BME is associated with cartilage loss in RA patients.

Cited by 7 publications

References 18 publications

Therapeutic Effect of Aquatic Resistance Exercise on Rectus Femoris and Knee in a Model of Rheumatoid Arthritis

Therapeutic Effect of Aquatic Resistance Exercise on Rectus Femoris and Knee in a Model of Rheumatoid Arthritis

Rheumatoid Arthritis of Knee Joints: MRI–Pathological Correlation

Rheumatoid Hand and Other Hand-deforming Rheumatic Conditions

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