Cartilage-like protein hydrogels engineered via entanglement

Fu, Linglan; Li, Lan; Bian, Qingyuan; Xue, Bin; Jin, Jing; Li, Jiayu; Cao, Yi; Jiang, Qing; Li, Hongbin

doi:10.1038/s41586-023-06037-0

Cited by 98 publications

(44 citation statements)

References 60 publications

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“…This showed that adding QCP not only enhanced the cross-linking network of adhesive, but also formed a bridge connecting the adhesive backbone to the nanosheets. In summary, the XPS findings were in alignment with the FTIR, 13 C NMR and 11 B NMR results, confirming the generation of Schiff base and B−O bonds in the dual bioinspired adhesive.…”

Section: Resultssupporting

confidence: 74%

Desirable Strong and Tough Adhesive Inspired by Dragonfly Wings and Plant Cell Walls

Zeng,

Dong,

Luo

et al. 2024

ACS Nano

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The production of wood-based panels has a significant demand for mechanically strong and flexible biomass adhesives, serving as alternatives to nonrenewable and toxic formaldehyde-based adhesives. Nonetheless, plywood usually exhibits brittle fracture due to the inherent trade-off between rigidity and toughness, and it is susceptible to damage and deformation defects in production applications. Herein, inspired by the microstructure of dragonfly wings and the cross-linking structure of plant cell walls, a soybean meal (SM) adhesive with great strength and toughness was developed. The strategy was combined with a multiple assembly system based on the tannic acid (TA) stripping/modification of molybdenum disulfide (MoS 2 @TA) hybrids, phenylboronic acid/quaternary ammonium doubly functionalized chitosan (QCP), and SM. Motivated by the microstructure of dragonfly wings, MoS 2 @TA was tightly bonded with the SM framework through Schiff base and strong hydrogen bonding to dissipate stress energy through crack deflection, bridging, and immobilization. QCP imitated borate chemistry in plant cell walls to optimize interfacial interactions within the adhesive by borate ester bonds, boron−nitrogen coordination bonds, and electrostatic interactions and dissipate energy through sacrificial bonding. The shear strength and fracture toughness of the SM/QCP/ MoS 2 @TA adhesive were 1.58 MPa and 0.87 J, respectively, which were 409.7% and 866.7% higher than those of the pure SM adhesive. In addition, MoS 2 @TA and QCP gave the adhesive good mildew resistance, durability, weatherability, and fire resistance. This bioinspired design strategy offers a viable and sustainable approach for creating multifunctional strong and tough biobased materials.

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Section: Resultssupporting

confidence: 74%

Desirable Strong and Tough Adhesive Inspired by Dragonfly Wings and Plant Cell Walls

Zeng,

Dong,

Luo

et al. 2024

ACS Nano

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“…Consequently, three-dimensional (3D) bioprinting has been increasingly used to replicate the 3D geometry of organs and precisely deposit cells within these organ analogs. Meanwhile, polymer hydrogels are the preferred choice for cell scaffold and printing bioink owing to their similarity to the extracellular matrix and suitability for cellular encapsulation and bioprinting [1,2]. Nonetheless, hydrogels inherently comprise a substantial water content and are soft, frequently leading to diminished resolution of printed layers and the rapid collapse of tissue and organ-scale constructs during conventional bioprinting.…”

Section: Introductionmentioning

confidence: 99%

Cation-crosslinked κ-carrageenan sub-microgel medium for high-quality embedded bioprinting

Zhang,

Luo,

et al. 2024

Biofabrication

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Three-dimensional (3D) bioprinting embedded within a microgel bath has emerged as a promising strategy for creating intricate biomimetic scaffolds. However, it remains a great challenge to construct tissue-scale structures with high resolution by using embedded 3D bioprinting due to the large particle size and polydispersity of the microgel medium, as well as its limited cytocompatibility. To address these issues, novel uniform sub-microgels of cell-friendly cationic-crosslinked kappa-carrageenan (κ-Car) are developed through an easy-to-operate mechanical grinding strategy. These κ-Car sub-microgels maintain a uniform submicron size of around 642 nm and display a rapid jamming-unjamming transition within 5s, along with excellent shear-thinning and self-healing properties, which are critical for the high resolution and fidelity in the construction of tissue architecture via embedded 3D bioprinting. Utilizing this new sub-microgel medium, various intricate 3D tissue and organ structures, including the heart, lungs, trachea, branched vasculature, kidney, auricle, nose, and liver, are successfully fabricated with delicate fine structures and high shape fidelity. Moreover, the bone marrow mesenchymal stem cells encapsulated within the printed constructs exhibit remarkable viability exceeding 92.1% and robust growth. This κ-Car sub-microgel medium offers an innovative avenue for achieving high-quality embedded bioprinting, facilitating the fabrication of functional biological constructs with biomimetic structural organizations.

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“…24 Their research revealed that stiff hydrogels promoted osteogenic differentiation, hydrogels with moderate mechanical properties favored chondrogenic differentiation, and soft hydrogels facilitated adipogenic differentiation. 25–27…”

Section: Introductionmentioning

confidence: 99%

Dual-network DNA–silk fibroin hydrogels with controllable surface rigidity for regulating chondrogenic differentiation

Zhou,

Song,

et al. 2024

Mater. Horiz.

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Cartilage-like protein hydrogels engineered via entanglement

Cited by 98 publications

References 60 publications

Desirable Strong and Tough Adhesive Inspired by Dragonfly Wings and Plant Cell Walls

Desirable Strong and Tough Adhesive Inspired by Dragonfly Wings and Plant Cell Walls

Cation-crosslinked κ-carrageenan sub-microgel medium for high-quality embedded bioprinting

Dual-network DNA–silk fibroin hydrogels with controllable surface rigidity for regulating chondrogenic differentiation

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