Cartilage Healing After Microfracture in Osteoarthritic Knees

Bae, Dae Kyung; Yoon, Kyoung Ho; Song, Sang Jun

doi:10.1016/j.arthro.2006.01.015

Cited by 228 publications

(184 citation statements)

References 28 publications

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“…Marrow stimulation, usually in the form of microfracture, relies on local recruitment of marrow based stem cells and growth factors to the site of articular repair [12]. The resulting fibrocartilaginous repair does not resemble surrounding hyaline cartilage, consisting of less collagen type II [13]. A prospective study on microfracture showed good to excellent in 67% of patients following a mean postoperative follow-up period of 3.6 years [14].…”

Section: Introductionmentioning

confidence: 99%

Bioengineering of Articular Cartilage: Past, Present and Future

Felimban

Moulton

et al. 2013

Regen. Med.

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The treatment of cartilage defects poses a clinical challenge owing to the lack of intrinsic regenerative capacity of cartilage. The use of tissue engineering techniques to bioengineer articular cartilage is promising and may hold the key to the successful regeneration of cartilage tissue. Natural and synthetic biomaterials have been used to recreate the microarchitecture of articular cartilage through multilayered biomimetic scaffolds. Acellular scaffolds preserve the microarchitecture of articular cartilage through a process of decellularization of biological tissue. Although promising, this technique often results in poor biomechanical strength of the graft. However, biomechanical strength could be improved if biomaterials could be incorporated back into the decellularized tissue to overcome this limitation.

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Section: Introductionmentioning

confidence: 99%

Bioengineering of Articular Cartilage: Past, Present and Future

Felimban

Moulton

et al. 2013

Regen. Med.

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“…We are aware of only 1 other study that demonstrated increased joint space 2 years after a cartilage repair procedure. In that study, the authors performed conventional microfracture in osteoarthritic knees and noted an average joint space improvement of 1.06 mm on weight bearing AP radiographs taken at a mean of 27 months postoperatively [27]. This improvement in joint space, however, did not persist after 10 years of follow-up [28].…”

Section: Discussionmentioning

confidence: 99%

Biologic Augmented Microdrilling Surgery for Multiple and Large Full-Thickness Cartilage Lesions in the Knee: Early Clinical and Radiological Results

Broyles¹,

O’Brien²,

Broyles³

et al. 2017

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Background: Various biologic treatments are available for articular cartilage lesions in the knee, but no one exists that is applicable to the full range of chondral disease and that is compliant with United States Food and Drug Administration regulations. The aim of this study was to evaluate outcomes following microdrilling surgery augmented with postoperative injections of bone marrow aspirate concentrate (BMAC), platelet rich plasma (PRP) and hyaluronic acid (HA). Methods: Eighteen patients with at least one symptomatic, full-thickness chondral lesion underwent arthroscopic microdrilling surgery. Immediately following surgery, patients received an intra-articular injection of fresh BMAC, PRP, and HA. This injection was repeated once per week for 5 consecutive weeks. At 4 and 12 months postoperatively, patients received 3 additional weekly injections for a total of 12 injections. Outcome Measures: IKDC (International Knee Documentation Committee) scores, KS (Knee Society) scores and plain radiographs. Results: The mean treated area was 6.2 ± 4.5 (range, 0.6 -14.7) cm 2 . The mean preoperative IKDC and KS scores (±SE) were 43.0 ± 3.2 and 68.3 ± 3.6 respectively. At 24 months postoperatively, IKDC and KS scores improved to 85.3 ± 4.2 and 94.7 ± 4.4, respectively; both changes from baseline were significant (p < 0.001). Radiographic analysis revealed that 9 of 18 patients in this series had joint space (JS) narrowing preoperatively. At 24 months, there was a 0.7 ± 0.3 mm overall increase in JS (p = 0.05). This change was greater in patients with preoperative JS < 2 mm, with an increase of 1.4 ± 0.5 mm (p for the difference between groups = 0.1). Conclusions: Microdrilling of cartilage lesions augmented with BMAC, PRP, and HA may be a viable treatment for a range of chondral disease with good early clinical and radiological results.

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“…This resulted in formation of combination of fibro cartilage with hyaline like cartilage resulting in good patient outcomes [21]. This technique was used in shoulder joint in our patient.…”

Section: Discussionmentioning

confidence: 99%

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2017

BAOJORT

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Cartilage Healing After Microfracture in Osteoarthritic Knees

Cited by 228 publications

References 28 publications

Bioengineering of Articular Cartilage: Past, Present and Future

Bioengineering of Articular Cartilage: Past, Present and Future

Biologic Augmented Microdrilling Surgery for Multiple and Large Full-Thickness Cartilage Lesions in the Knee: Early Clinical and Radiological Results

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