Cartilage antigen dependent lymphotoxin release. Immunopathological significance in articular destructive disorders.

Herman, Jerome H.; Houk, J. Lawrence; Dennis, Marie V.

doi:10.1136/ard.33.5.446

Cited by 14 publications

(3 citation statements)

References 24 publications

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“…tory and immune responses in osteoarthrotic joints [2][3][4][5]. Symptoms of inflammation, which include swelling, redness, stiffness and pain, are present in many patients.…”

mentioning

confidence: 99%

Therapeutic Interventions in the Treatment of Acute and Chronic Pain in Osteoarthrosis

Moskowitz¹

1988

Osteoarthritis

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“…tory and immune responses in osteoarthrotic joints [2][3][4][5]. Symptoms of inflammation, which include swelling, redness, stiffness and pain, are present in many patients.…”

mentioning

confidence: 99%

Therapeutic Interventions in the Treatment of Acute and Chronic Pain in Osteoarthrosis

Moskowitz¹

1988

Osteoarthritis

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“…vation may function in the causation and/or perpetuation of articular inflammation and cartilage degradation. Lymphocyte sensitization to cartilage proteoglycan and type I1 collagen has been demonstrated both in patients with overt inflammatory and those with degenerative forms of destructive arthropathy (10)(11)(12)(13)(14)(15)(16).…”

mentioning

confidence: 99%

“…Qualitative and quantitative changes in the proteoglycan content of articular cartilage derived from patients having rheumatoid arthritis or degenerative joint disease are well recognized (1 [7][8][9][10][11][12][13][14][15][16][17][18][19]. Such changes likely reflect both enhanced catabolism as well as aberrations in chondrocyte synthesis.…”

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confidence: 99%

Lymphokine‐mediated suppression of chondrocyte glycosaminoglycan and protein synthesis

Herman

Nutman

Nozoe

et al. 1981

Arthritis & Rheumatism

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Spontaneously released and T cell mitogen augmented lymphokine produced by human mononuclear cells has been shown to induce a concentration dependent reversible suppression of chondrocyte glycosaminoglycan and protein synthesis without significantly enhancing chondrocyte catabolic activity. The modulatory factor(s) is of T cell origin and is trypsin, pronase, and heat sensitive. Prostaglandin inhibitors failed to influence factor formation or activity. Although eluting from Sephadex G-100 over a wide range, peak activity had an approximate molecular weight of 53,000 and appeared distinct from recognized forms of lymphotoxin.Mounting evidence, albeit largely circumstantial, has implicated cell mediated immunologic mechanisms in the pathogenesis of human and experimental animal models of articular disease. Thus the predominant mononuclear cell infiltrating synovial membranes and that present in synovial fluids secured from distinct

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Periarticular uptake of ^99mtechnetium diphosphonate in psoriatics. Correlation with cutaneous activity

Namey

Rosenthall

1976

Arthritis & Rheumatism

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The periarticular uptake of 99mtechnetium‐labeled diphosphonate (99mTcDP) was compared in 12 patients hospitalized for psoriasis and in 12 hospitalized for other dermatoses not associated with arthropathy. The 12 patients with psoriasis had recent onset disease of less than 5 years duration; neither group had historical or clinical evidence of arthritis. All psoriatics had markedly abnormal scans with symmetrically increased periarticular uptake about the imaged joints. None of the controls had similar findings. In 4 patients scanned with 99mtechnetium‐pertechnetate within 24 hours of their 99mTcDP scan, no evidence of inflammatory synovitis was found. Three of these patients were serially imaged with 99mTcDP at intervals of 2 weeks to 3 months after their initial study, when obvious clinical improvement in their psoriasis was apparent. Improvement in the radionuclide joint images was demonstrated in some of the patients, but none reverted to normal during the study period. In light of recent evidence for the preferential binding of 99mTcDP to immature collagen, it is suggested that psoriasis may represent a generalized, but uncharacterized, collagen disorder present in bone as well as skin, linking the cutaneous disease with the potential for arthropathy.

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Cartilage antigen dependent lymphotoxin release. Immunopathological significance in articular destructive disorders.

Cited by 14 publications

References 24 publications

Therapeutic Interventions in the Treatment of Acute and Chronic Pain in Osteoarthrosis

Therapeutic Interventions in the Treatment of Acute and Chronic Pain in Osteoarthrosis

Lymphokine‐mediated suppression of chondrocyte glycosaminoglycan and protein synthesis

Periarticular uptake of ^99mtechnetium diphosphonate in psoriatics. Correlation with cutaneous activity

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Cartilage antigen dependent lymphotoxin release. Immunopathological significance in articular destructive disorders.

Cited by 14 publications

References 24 publications

Therapeutic Interventions in the Treatment of Acute and Chronic Pain in Osteoarthrosis

Therapeutic Interventions in the Treatment of Acute and Chronic Pain in Osteoarthrosis

Lymphokine‐mediated suppression of chondrocyte glycosaminoglycan and protein synthesis

Periarticular uptake of 99mtechnetium diphosphonate in psoriatics. Correlation with cutaneous activity

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Periarticular uptake of ^99mtechnetium diphosphonate in psoriatics. Correlation with cutaneous activity