Carthamus tinctorius L. extract improves hemodynamic and vascular alterations in a rat model of renovascular hypertension through Ang II-AT 1 R-NADPH oxidase pathway

Bunbupha, Sarawoot; Wunpathe, Chutamas; Maneesai, Putcharawipa; Berkban, Thewarid; Kukongviriyapan, Upa; Kukongviriyapan, Veerapol; Prachaney, Parichat; Pakdeechote, Poungrat

doi:10.1016/j.aanat.2017.11.005

Cited by 13 publications

(6 citation statements)

References 36 publications

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“…Such results were attributed to a complete normalization of blood pressure and AT1 receptor blockade 46 . Additionally, previous observations support that the treatment of 2K‐1C rats with captopril (5 mg/kg/d) markedly alleviated haemodynamic alterations, aortic remodelling, RAS overactivity and oxidative stress in 2K‐1C hypertensive rats 47 . Such results may justify the findings of reduction in vascular hypertrophy observed in our study in 2K‐1C rats treated with enalapril and/or losartan.…”

Section: Discussionsupporting

confidence: 88%

Reversion of cardiovascular remodelling in renovascular hypertensive 2K‐1C rats by renin–angiotensin system inhibitors

Corrêa

Prado

Araújo

et al. 2020

Clin Exp Pharma Physio

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Objectives Evaluate whether the RAS dual blockade would induce additional beneficial effects on cardiovascular remodelling when compared to monotherapy in renal hypertensive two kidneys–one clip (2K‐1C) rats. Methods Hypertensive 2K‐1C and normotensive (2K) rats were treated for 14 days with submaximal doses of losartan (LOS), enalapril (ENA), losartan plus enalapril (LOS + ENA) or vehicle (water). Blood pressure and some parameters of cardiovascular remodelling were evaluated. Results Systolic blood pressure (SBP) was higher in 2K‐1C (209 ± 3 mm Hg, P < .05) than in 2K (113 ± 1 mm Hg) rats. There was an additional effect in 2K‐1C treated with LOS + ENA (153 ± 9 mm Hg) on lowering SBP when compared to LOS (184 ± 12 mm Hg) or ENA (177 ± 9 mm Hg). None of the treatments had effect on SBP in 2K rats. In 2K‐1C, cardiomyocyte hypertrophy was reduced by all treatments, although the cardiac hypertrophy indexes remained unchanged. 2K‐1C aortas presented medial thickening that was partially reduced by the treatments. Intimal hyperplasia observed in 2K‐1C (15.56 ± 0.89 µm vs 8.24 ± 0.80 µm) was reversed by ENA (9.52 ± 0.45 µm) or LOS + ENA (8.17 ± 0.53 µm). Collagen deposition was increased in 2K‐1C hearts (1.77 ± 0.16 vs 1.28 ± 0.09) and aortas (8.1 ± 0.6 vs 5.2 ± 0.2). Treatment with LOS reduced (1.12 ± 0.14%) and ENA (0.81 ± 0.11%) or LOS + ENA (0.86 ± 0.11%) additionally diminished collagen only in 2K‐1C hearts. Conclusions Submaximal doses of ACEi and/or ARB have inhibitory actions on cardiac remodelling and vascular hypertrophy not entirely dependent on their effects on blood pressure normalization in renovascular hypertensive rats. Combined therapy produced additional reduction in blood pressure than monotherapy despite a similar inhibition on cardiovascular remodelling.

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Section: Discussionsupporting

confidence: 88%

Reversion of cardiovascular remodelling in renovascular hypertensive 2K‐1C rats by renin–angiotensin system inhibitors

Corrêa

Prado

Araújo

et al. 2020

Clin Exp Pharma Physio

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“…Oxidative stress has been linked to hypertension and other cardiovascular disorders . From this study, NaF alone caused increase in systolic blood pressure (SBP), DBP, and MAP as compared to rats coadministered with Luteolin and the control rats.…”

Section: Discussionmentioning

confidence: 84%

Luteolin‐mediated Kim‐1/NF‐kB/Nrf2 signaling pathways protects sodium fluoride‐induced hypertension and cardiovascular complications

et al. 2018

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The use of sodium fluoride (NaF) as a major ingredient for tooth paste, mouth wash, and mouth rinse has become inevitable in our day-to-day life. However, flavonoids such as Luteolin might be of great value in the prevention of toxicity associated with accidental or inevitable ingestion of NaF. In the study, 40 male Wistar albino rats were randomly divided into four groups with 10 rats in a group. Group A was the control group and received normal saline, Group B was exposed to NaF at 300 ppm (300 mg/L) in drinking water daily for a week, Groups C and D were exposed to 300 ppm (300 mg/L) of NaF and coadministered with Luteolin orally daily at a dosage of 100 mg/kg and 200 mg/kg for the same time point. Our results indicated that NaF caused significant increases in systolic blood pressure, diastolic blood pressure, mean arterial pressure, malondialdehyde, protein carbonyl, myeloperoxidase, advanced oxidative protein products, together with significant reductions in glutathione peroxidase, superoxide dismutase, catalase, glutathione reductase, reduced glutathione, and nitric oxide (NO) bioavailability. The electrocardiogram results showed that NaF alone caused significant prolongation of QT and QTc intervals. Immunohistochemistry revealed that NaF caused increase expressions of Kidney injury marker 1 (Kim-1), nuclear factor 518 BioFactors Research Communication kappa bet (NF-κB), nuclear factor erythroid 2-related factors 2 (Nrf2), and cardiac troponin I (CTnI). Together, Luteolin coadministration with NaF improved NO bioavailability, reduced high blood pressure, markers of oxidative stress, reversed prolongation of QT and QTc intervals, and lowered the expressions of Kim-1, NF-κB, and CTnI. © 2018 BioFactors, 44(6):518-531, 2018

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“…Rats were treated with C. tinctorius (CT) extract (500 mg/kg/day) for four weeks, studying renovascular hypertension. The findings suggested that CT extract produces inhibitory effects of hemodynamic alteration and vascular remodeling in 2K-1C hypertensive rats and has potent antioxidant activity [88]. HSYA was injected at different doses (0, 10, 20, and 40 mg/kg) and the effects of HSYA on hypertensive ventricular remodeling was studied using the rat model of left ventricular hypertrophy, and findings included mechanism of inhibiting cell apoptosis and suppressing metalloproteinases expression [89].…”

Section: Vascular Effectsmentioning

confidence: 99%

A Metabolic Perspective and Opportunities in Pharmacologically Important Safflower

et al. 2020

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Safflower (Carthamus tinctorius L.) has long been grown as a crop due to its commercial utility as oil, animal feed, and pharmacologically significant secondary metabolites. The integration of omics approaches, including genomics, transcriptomics, metabolomics, and proteomics datasets, has provided more comprehensive knowledge of the chemical composition of crop plants for multiple applications. Knowledge of a metabolome of plant is crucial to optimize the evolution of crop traits, improve crop yields and quality, and ensure nutritional and health factors that provide the opportunity to produce functional food or feedstuffs. Safflower contains numerous chemical components that possess many pharmacological activities including central nervous, cardiac, vascular, anticoagulant, reproductive, gastrointestinal, antioxidant, hypolipidemic, and metabolic activities, providing many other human health benefits. In addition to classical metabolite studies, this review focuses on several metabolite-based working techniques and updates to provide a summary of the current medical applications of safflower.

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Carthamus tinctorius L. extract improves hemodynamic and vascular alterations in a rat model of renovascular hypertension through Ang II-AT 1 R-NADPH oxidase pathway

Cited by 13 publications

References 36 publications

Reversion of cardiovascular remodelling in renovascular hypertensive 2K‐1C rats by renin–angiotensin system inhibitors

Reversion of cardiovascular remodelling in renovascular hypertensive 2K‐1C rats by renin–angiotensin system inhibitors

Luteolin‐mediated Kim‐1/NF‐kB/Nrf2 signaling pathways protects sodium fluoride‐induced hypertension and cardiovascular complications

A Metabolic Perspective and Opportunities in Pharmacologically Important Safflower

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