Carrot Intake is Consistently Negatively Associated with Cancer Incidence: A Systematic Review and Meta-Analysis of Prospective Observational Studies

Dietary carrot intake compared favourably with three other vegetable groups in protection against incidence of cancers: A systematic review and meta-analysis

“…Significantly decreased (P<0.017) risks of cancers were associated with the intake of each vegetable: carrots RR 0.66, 95%CI 0.60-0.72; tomatoes 0.76, 0.68–0.85; green leafy vegetables 0.74, 0.65–84; and cruciferous vegetables 0.84 0.76–0.97. Carrot intake significantly decreased the risk of cancers (P<0.01) more than cruciferous vegetables (4) .…”

“…A comprehensive protocol was published on PROSPERO with ID CRD42019124009 and the results of the present meta-analysis were included (with other analyses) in the first version of a pre-print (4) ; however, the comparison with other vegetables was removed from subsequent versions of that manuscript, so this will not be published elsewhere before July 2023.PubMed, Cochrane Library, Web of Science, Scopus, EBSCO, and JSTOR were searched, from database inception to June 2022, for studies reporting risk estimates with 95% CIs for the relationship between carrot intake and the risk of cancers, and studies were included in the present analysis if they also reported the associations with the intake of any of the above-mentioned vegetables. Using a random-effects model, a meta-analysis was conducted comparing the highest and lowest intakes to estimate summary risk estimates (RRs) and 95% confidence intervals (CIs) in retrospective studies.Out of 58 studies with 64,131 cases that reported data on carrots and at least one of the other vegetables being investigated, 11 were prospective studies and 47 retrospective (4) . Due to substantial interaction with study design (prospective/retrospective), only retrospective studies were included in the present analysis, since while the RR values from prospective studies are more reliable than from retrospective studies, the number of prospective studies was too low for this comparison.…”

“…Out of 58 studies with 64,131 cases that reported data on carrots and at least one of the other vegetables being investigated, 11 were prospective studies and 47 retrospective (4) . Due to substantial interaction with study design (prospective/retrospective), only retrospective studies were included in the present analysis, since while the RR values from prospective studies are more reliable than from retrospective studies, the number of prospective studies was too low for this comparison.…”

“…We hypothesized that (1) carrot consumption is associated with reduced risks of cancers, and (2) carrots offer greater or equal protective effects compared with tomatoes, cruciferous, and green leafy vegetables. A comprehensive protocol was published on PROSPERO with ID CRD42019124009 and the results of the present meta-analysis were included (with other analyses) in the first version of a pre-print (4) ; however, the comparison with other vegetables was removed from subsequent versions of that manuscript, so this will not be published elsewhere before July 2023.…”