Carrier-free nanoprodrug for p53-mutated tumor therapy via concurrent delivery of zinc-manganese dual ions and ROS

Wang, Jinping; Qu, Chang; Shao, Xinyue; Song, Guoqiang; Sun, Jingyu; Shi, Da–Hua; Jia, Ru; An, Hailong; Wang, Hongjun

doi:10.1016/j.bioactmat.2022.06.005

Cited by 16 publications

(14 citation statements)

References 67 publications

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“…Wt-p53 is a tumor suppressor protein, which can induce apoptosis and promote cell differentiation through various ways. The loss of oncogenic effects in the mutant p53 leads to the development of a variety of tumors [35]. The results of this study showed that the ADC values (ADC max , ADC mean , and ADC min ) were signi cantly lower in p53 positive group than in the negative group.…”

Section: Discussionmentioning

confidence: 60%

Development of an apparent diffusion coefficient based on nomogram for the preoperative prediction of Ki-67 and p53 expression levels and myometrial infiltration in endometrial cancer

Zhang

Jing

Cao

et al. 2023

Preprint

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Background Endometrial cancer (EC) has been increasing in incidence and mortality rates over the years. To investigate the feasibility of ADC in preoperative non-invasive prediction of myometrial infiltration and Ki-67 and p53 expression levels in patients with EC. Methods we performed the retrospective analysis of 105 patients with EC who underwent preoperative magnetic resonance imaging (MRI) diffusion weighted imaging (DWI) and were confirmed by pathology after operation from January 2017 to December 2021 in our hospital. Two independent radiologists measured the ADC values (ADCmax, ADCmean, and ADCmin) of EC on the ADC image by comparing the MRI enhancement and DWI images, respectively. Statistical methods were used to calculate the correlation between clinical information, ADC values and myometrial infiltration and Ki-67 and p53 expression in EC patients. A nomogram prediction model was constructed and evaluated via receiver operating characteristic (ROC) curve and calibration curve analysis. Results The ADC values were significantly correlated with the myometrial infiltration and Ki-67 and p53 expression levels in EC patients (all P < 0.05). The International Federation of Gynecology and Obstetrics (FIGO) stage only significantly associated with the myometrial infiltration and Ki-67 expression levels in EC patients (all P < 0.05). The ADCmax, ADCmean, and ADCmin were combined with the FIGO stage to construct the nomogram model. The nomogram model, ADCmax, ADCmean, ADCmin, and FIGO stage predicted AUC values of 0.809, 0.707, 0.693, 0.694, and 0.599 for myometrial infiltration, respectively; the AUC values for predicting Ki-67 expression levels were 0.897, 0.879, 0.849, 0.808 and 0.550, respectively. The nomogram model was constructed by combining the ADCmax, ADCmean, ADCmin. The AUC values predicted by the nomogram, ADCmax, ADCmean, ADCmin were 0.665, 0.615, 0.641 and 0.654, respectively. Conclusions The nomogram model based on ADC values combined with the FIGO stage could be a useful method for the preoperative non-invasive assessment of myometrial infiltration and Ki-67 and p53 expression in EC patients.

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Section: Discussionmentioning

confidence: 60%

Development of an apparent diffusion coefficient based on nomogram for the preoperative prediction of Ki-67 and p53 expression levels and myometrial infiltration in endometrial cancer

Zhang

Jing

Cao

et al. 2023

Preprint

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“…Meanwhile, 14-3-3σ can also improve the stability and transcriptional activity of p53 in a feedback [ 35 ]. However, many studies confirmed that p53 is abnormally increased as mutant p53 forms in some tumor tissues or cells [ 36 ], and does not possess a negative regulatory effect on cell proliferation [ 37 , 38 ]. Some studies also confirmed that ALV-J infection can induce mutation of p53 gene and increase mRNA expression [ 13 , 39 ], and some mutant forms of p53 might be involved in the development of tumors induced by ALV-J [ 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

J Subgroup Avian Leukosis Virus Strain Promotes Cell Proliferation by Negatively Regulating 14-3-3σ Expressions in Chicken Fibroblast Cells

Wang

Sun

et al. 2023

Viruses

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This study focuses on clarifying the regulation of chicken 14-3-3σ protein on the fibrous histiocyte proliferation caused by ALV-J-SD1005 strain infection. DF-1 cells were inoculated with 102 TCID50 of ALV-J-SD1005 strain; the cell proliferation viability was dramatically increased and 14-3-3σ expressions were dramatically decreased within 48 hours after inoculation. Chicken 14-3-3σ over-expression could significantly decrease the cell proliferation and the ratio of S-phase cells, but increase the ratio of G2/M-phase cells in ALV-J-infected DF-1 cells; by contrast, chicken 14-3-3σ knockdown expression could cause the opposite effects. Additionally, chicken 14-3-3σ over-expression could also dramatically down-regulate the expressions of CDK2/CDC2, but up-regulate p53 expressions in the DF-1 cells; in contrast, the knockdown expression could significantly increase the expressions of CDK2/CDC2 and decrease p53 expressions. It can be concluded that chicken 14-3-3σ can inhibit cell proliferation and cell cycle by regulating CDK2/CDC2/p53 expressions in ALV-J-infected DF1 cells. ALV-J-SD1005 strain can promote cell proliferation by reducing 14-3-3σ expressions. This study helps to clarify the forming mechanism of acute fibrosarcoma induced by ALV-J infection.

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“…The hypoxia-associated risk score model is reported to be associated with poor prognosis through the immunosuppressive microenvironment and immune escape mechanisms (Pei et al, 2021). Meanwhile, Wang et al (2023) have reported the therapeutic properties of reactive oxygen species for its negative Frontiers in Genetics frontiersin.org regulation on tumor. Studies on hypoxia and the hypoxiaassociated pathway play roles in antitumor regulation and may predict immunotherapy outcomes in an era of machine learning and computational biology (Abou Khouzam et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Hypoxia-related tumor environment correlated with immune infiltration and therapeutic sensitivity in diffuse large B-cell lymphoma

Liu

2022

Front. Genet.

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Background: Due to the high heterogeneity of diffuse large B-cell lymphoma (DLBCL), traditional chemotherapy treatment ultimately failed in one-third of the patients. Big challenges existed in finding how to accurately predict prognosis and provide individualized treatment. Hypoxia, although being a key factor in the development and progression of DLBCL, plays its role in DLBCL prognosis, which has yet to be fully explored.Methods: Data used in the current study were sourced from the Gene Expression Omnibus (GEO) database. DLBCL patients were divided according to different hypoxia-related subtypes based on the expressions of hypoxia-related genes (HRGs) relevant to survival. Differentially expressed genes (DEGs) between subtypes were identified using the limma package. Using univariate Cox regression and least absolute shrinkage and selection operator (LASSO) analyses, the prognostic signature was established to calculate risk scores. The tumor microenvironment (TME) in low- and high-risk groups was evaluated by single-sample gene set enrichment analysis (ssGSEA) and ESTIMATE. The chemotherapeutic sensitivity in two groups was assessed by IC50 values.Results: DLBCL patients were clustered into two hypoxia-related subtype groups according to different gene survival and expressions associated with increasing oxygen delivery and reducing oxygen consumption, and these two subtype groups were compared. Based on the differential expression, a risk model was established using univariate cox and LASSO regression analyses, FNDC1, ANTXR1, RARRES2, S100A9, and MT1M. The performance of the risk signature in predicting the prognosis of DLBCL patients was validated in the internal and external datasets, as evidenced by receiver operating characteristic (ROC) curves. In addition, we observed significant differences in the tumor microenvironment and chemotherapeutic response between low- and high-risk groups.Conclusion: Our study developed novel hypoxia-related subtypes in DLBCL and identified five prognostic signatures for DLBCL patients. These findings may enrich our understanding of the role of hypoxia in DLBCL and help improve the treatment of DLBCL patients.

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Carrier-free nanoprodrug for p53-mutated tumor therapy via concurrent delivery of zinc-manganese dual ions and ROS

Cited by 16 publications

References 67 publications

Development of an apparent diffusion coefficient based on nomogram for the preoperative prediction of Ki-67 and p53 expression levels and myometrial infiltration in endometrial cancer

Development of an apparent diffusion coefficient based on nomogram for the preoperative prediction of Ki-67 and p53 expression levels and myometrial infiltration in endometrial cancer

J Subgroup Avian Leukosis Virus Strain Promotes Cell Proliferation by Negatively Regulating 14-3-3σ Expressions in Chicken Fibroblast Cells

Hypoxia-related tumor environment correlated with immune infiltration and therapeutic sensitivity in diffuse large B-cell lymphoma

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