Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs

Winter, Charles A.; Risley, Edwin A.; Nuss, G. W.

doi:10.3181/00379727-111-27849

Cited by 5,242 publications

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“…11 In the carrageenan paw oedema model, valdecoxib reduced inflammatory paw oedema by up to 70% compared with baseline values, an effect comparable with that of naproxen (67%). 12 Furthermore, in the Hargreaves hyperalgesia model, valdecoxib was able to reverse hyperalgesia by 97%, compared with 74% for naproxen. 13 In the rat adjuvant-induced arthritis model of chronic inflammation, the anti-inflammatory effect of valdecoxib was similar to that of indometacin, with maximal reductions in the swelling of the hind limb of 95% for the former and 93% for the latter.…”

Section: Mechanism Of Action Of Valdecoxibmentioning

confidence: 98%

The pharmacological properties and clinical use of valdecoxib, a new cyclo‐oxygenase‐2‐selective inhibitor

Alsalameh

Burian

Mahr

et al. 2003

Aliment Pharmacol Ther

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SUMMARYCyclo-oxygenase-2-selective inhibitors produce less gastric damage than conventional non-steroidal antiinflammatory drugs. Valdecoxib is a new orally administered cyclo-oxygenase-2-selective inhibitor, recently approved for use in osteoarthritis, rheumatoid arthritis and primary dysmenorrhoea in the USA. The drug has been evaluated in more than 60 clinical studies involving more than 14 000 patients and healthy volunteers. The analgesic efficacy of valdecoxib at a dose of 10 mg once daily in both osteoarthritis and rheumatoid arthritis is superior to that of placebo and similar to that of traditional non-steroidal anti-inflammatory drugs. Valdecoxib is effective in single doses of up to 40 mg for the alleviation of acute menstrual pain and has a rapid onset of action (within 30 min) and a long duration of analgesia (up to 24 h). Valdecoxib is well tolerated and has safety advantages compared with traditional non-steroidal anti-inflammatory drugs in terms of less gastrointestinal toxicity and a lack of an effect on platelet function. The incidence of adverse effects involving the kidney (fluid retention, oedema and hypertension) is similar to that of non-selective, nonsteroidal anti-inflammatory drugs.

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Section: Mechanism Of Action Of Valdecoxibmentioning

confidence: 98%

The pharmacological properties and clinical use of valdecoxib, a new cyclo‐oxygenase‐2‐selective inhibitor

Alsalameh

Burian

Mahr

et al. 2003

Aliment Pharmacol Ther

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“…Evaluation of anti-inflammatory activity of the extract 2.6.1. Carrageenin-induced mice hind paw oedema Increase in the mice hind paw linear circumference induced by plantar injection of the phlogistic agent was used as the measure of acute inflammation [11] . Adult albino mice of either sex were used after 24 h fast and deprived of water only during experiment.…”

Section: Determination Of Median Lethal Dose (Ld 50 )mentioning

confidence: 99%

“…The linear circumference of the injected paw was measured before and 0.5, 1, 2, 3, 4 and 5 h after administration of phlogistic agent. For routine drug testing, the increase in paw circumference 0.5, 1, 2, 3, 4 and 5 h after administration of phlogistic agent was adopted as the parameter for measuring inflammation [11,12] . Edema (inflammation) was assessed as difference in paw circumference between the control and 0.5, 1, 2, 3, 4 and 5 h after administration of phlogistic agent [13] .…”

Section: Determination Of Median Lethal Dose (Ld 50 )mentioning

confidence: 99%

Anti–inflammatory and analgesic activities of Melanthera scandens

Okokon

Udoh

Frank

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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“…The rats were divided in three groups: (1) Animals that received subcutaneous injection of 1% carrageenan type IV (0.1 mL) dissolved in saline, according to Winter et al (1962). (2) Animals that received vehicle (0.1 mL 0.9% NaCl).…”

Section: Materials and Methods Experimental Groupsmentioning

confidence: 99%

Inflammatory Process Induced by Carrageenan in Adjacent Tissue Triggers the Acute Inflammation in Deep Digital Flexor Tendon of Rats

Vieira

Aro

Guerra

et al. 2013

The Anatomical Record

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Tendinopathy is a pathology found mainly in the rotator cuff, patellar, Achilles and flexor tendons. Tendinopathy is a significant impediment to performance in athletes and in workers in the labor market. Some studies have indicated that inflammation in adjacent tissues may affect the rotator cuff and Achilles tendon. In this study alterations were verified in the extracellular matrix (ECM) of the deep digital flexor tendon after two periods (12 and 24 hr) of induction inflammation in rat paw. Wistar rats were divided into three groups: those that received injection of 1% carrageenan; those that received 0.9% NaCl; and those that received no application. The tendon was divided into distal (d), proximal (p), and intermediate (i) regions. Biochemical analyses were performed and included non-collagenous proteins (NCP), glycosaminoglycans (GAGs), hydroxyproline (HoPro) and metalloproteinases 2 and 9. Tissue sections were stained with toluidine blue, hematoxylin-eosin, and Ponceau SS and observed under polarization microscopy. Remarkable results were detected that included the presence of MMP-9, degradation of NCP and GAG and the presence of cellular infiltrate closer to digits in d region. The different concentrations of HoPro, as well as alterations in the organization of the collagen fibers showed the collagenous matrix undergoing some alterations. The results indicated that the induced inflammation in rat paw exhibited characteristics similar to the typical acute inflammatory process observed in tendons.

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Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs

Cited by 5,242 publications

References 0 publications

The pharmacological properties and clinical use of valdecoxib, a new cyclo‐oxygenase‐2‐selective inhibitor

The pharmacological properties and clinical use of valdecoxib, a new cyclo‐oxygenase‐2‐selective inhibitor

Anti–inflammatory and analgesic activities of Melanthera scandens

Inflammatory Process Induced by Carrageenan in Adjacent Tissue Triggers the Acute Inflammation in Deep Digital Flexor Tendon of Rats

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