Carpinus truczaninowii extract showed anti-inflammatory response on human aortic vascular smooth muscle cells

Yeo, JH; Son, YK; Bang, WY; Kim, OY

doi:10.1055/s-0036-1596441

Cited by 2 publications

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“…To induce clinically hyperglycemic condition, we stimulated the cells with 25 mM (450 mg/dL) of glucose. Based on our previous study for cell viability [27], we used 1 and 10 μg/mL concentration of C. turczaninowii extract in this study.…”

Section: Methodsmentioning

confidence: 99%

“…Among the natural compounds, phytochemical compounds derived from plants have been considered important all over the world because of their roles in increasing antioxidant capacity, regulating enzyme activity, and modulating gene transcription [19,20]. Carpinus turczaninowii ( C. turczaninowii ), a member of the Betulaceae family, has been reported to play a role in antioxidant regulation and anti-inflammation modulation [21,22,23,24,25,26,27]. Carpinus turczaninowii ( C. turczaninowii ), a member of the Betulaceae family (Korean hornbeam) usually grown in the Jeju islands of Korea, has been reported to play a role in antioxidant regulation and anti-inflammation modulation [21,22,23,24,25,26,27].…”

Section: Introductionmentioning

confidence: 99%

“…Carpinus turczaninowii ( C. turczaninowii ), a member of the Betulaceae family, has been reported to play a role in antioxidant regulation and anti-inflammation modulation [21,22,23,24,25,26,27]. Carpinus turczaninowii ( C. turczaninowii ), a member of the Betulaceae family (Korean hornbeam) usually grown in the Jeju islands of Korea, has been reported to play a role in antioxidant regulation and anti-inflammation modulation [21,22,23,24,25,26,27]. Recent studies showed dose-dependent inhibition of nitric oxide (NO) and interleukin (IL)-6 productions from LPS-stimulated RAW264.7 cells (1 μg/mL of LPS) by the extract of C. turczaninowii branches and leaves (12.5 to 200 μg/mL) [21,22,23,24].…”

Section: Introductionmentioning

confidence: 99%

“…In our recent study, a complete extract of C. turczaninowii was found to contain high amounts of total phenolic compounds (225.6 ± 21.0 mg of gallic acid equivalents/g of the extract), as well as strongly scavenged free radicals (average 14.8 ± 1.97 μg/mL IC 50 at 40 min) [27]. In addition, mRNA expressions of interleukin-6 (IL-6) and tumor necrosis factor (TNF)-α in human aortic vascular smooth muscle cells (hASMCs) were significantly suppressed by the extracts (1 and 10 μg/mL) at 6 h after exposure, and IL-6 secretion was dose-dependently suppressed at 2 h and 24 h after incubation with the extract at 1–10 μg/mL in non-stimulated and LPS-stimulated cells [27]. Given that C. turczaninowii has antioxidant capacity, we hypothesized that it may protect arterial cells from the hyperglycemia-induced oxidative stress, but the mechanism is not fully understood.…”

Section: Introductionmentioning

confidence: 99%

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Carpinus turczaninowii Extract May Alleviate High Glucose-Induced Arterial Damage and Inflammation

et al. 2019

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Hyperglycemia-induced oxidative stress triggers severe vascular damage and induces an inflammatory vascular state, and is, therefore, one of the main causes of atherosclerosis. Recently, interest in the natural compound Carpinus turczaninowii has increased because of its reported antioxidant and anti-inflammatory properties. We investigated whether a C. turczaninowii extract was capable of attenuating high glucose-induced inflammation and arterial damage using human aortic vascular smooth muscle cells (hASMCs). mRNA expression levels of proinflammatory response [interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)], endoplasmic reticulum (ER) stress [CCAAT-enhancer-binding proteins (C/EBP) homologous protein (CHOP)], and adenosine monophosphate (AMP)-protein activated kinase α2 (AMPK α2)], and DNA damage [phosphorylated H2.AX (p-H2.AX)] were measured in hASMCs treated with the C. turczaninowii extracts (1 and 10 μg/mL) after being stimulated by high glucose (25 mM) or not. The C. turczaninowii extract attenuated the increased mRNA expression of IL-6, TNF-α, and CHOP in hASMCs under high glucose conditions. The expression levels of p-H2.AX and AMPK α2 induced by high glucose were also significantly decreased in response to treatment with the C. turczaninowii extract. In addition, 15 types of phenolic compounds including quercetin, myricitrin, and ellagic acid, which exhibit antioxidant and anti-inflammatory properties, were identified in the C. turczaninowii extract through ultra-performance liquid chromatography-quadrupole-time of flight (UPLC-Q-TOF) mass spectrometry. In conclusion, C. turczaninowii may alleviate high glucose-induced inflammation and arterial damage in hASMCs, and may have potential in the treatment of hyperglycemia-induced atherosclerosis.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Carpinus turczaninowii Extract May Alleviate High Glucose-Induced Arterial Damage and Inflammation

et al. 2019

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Ecophysiological Responses of Carpinus turczaninowii L. to Various Salinity Treatments

Zhou

Shi

Zhu

et al. 2019

Forests

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Carpinus turczaninowii L., commonly known as hornbeam, has significant economic and ornamental importance and is largely distributed in the northern hemisphere, including parts of China and Korea, with high adaptation to harsh conditions in very unfertile soils. In this study, the ecophysiological responses of C. turczaninowii seedlings to various salinity stress treatments (NaCl: 0, 17, 34, 51, 68, and 85 mM) were studied for 42 days by determining stress-induced changes in growth parameters and biochemical markers. Salinity stress affected the values of all the examined parameters, both morphological and physiological, and caused the inhibition of plant growth, the degradation of photosynthetic capacity and stomatal behavior, a decrease in the photosynthetic pigments contents and relative water content, an increase in the Malondialdehyde (MDA) content and relative electrolytic conductivity, and the accumulation of Na+ and Cl− content. The presence of relatively high concentrations of organic osmolytes, the activation of antioxidant enzymes, and the ionic transport capacity from the root to shoots may represent a constitutive mechanism of defence against stress in C. turczaninowii seedlings. Our results suggest that C. turczaninowii can tolerate salinity at low and moderate concentrations (17–51 mM) under nursery conditions and can be widely used in roadsides, gardens, parks, and other urban areas.

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Carpinus truczaninowii extract showed anti-inflammatory response on human aortic vascular smooth muscle cells

Cited by 2 publications

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Carpinus turczaninowii Extract May Alleviate High Glucose-Induced Arterial Damage and Inflammation

Carpinus turczaninowii Extract May Alleviate High Glucose-Induced Arterial Damage and Inflammation

Ecophysiological Responses of Carpinus turczaninowii L. to Various Salinity Treatments

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